DOI QR코드

DOI QR Code

Treatment of an Atrophic Scar with Fractional Carbon Dioxide Laser-assisted Poly-L-lactic Acid Delivery

  • Kim, Wan Jin (Department of Dermatology, Hanyang University Medical Center, Myongji Hospital) ;
  • Jung, Ha Rin (Ernest Mario School of Pharmacy, Rutgers University) ;
  • Lee, Sang Ju (Yonsei Star Skin & Laser Clinic) ;
  • Cho, Han Kyoung (Department of Dermatology, Hanyang University Medical Center, Myongji Hospital)
  • 투고 : 2021.07.12
  • 심사 : 2021.08.16
  • 발행 : 2021.09.30

초록

Scars can cause great psychological stress among patients. Currently, there are numerous topical agents, laser and surgical treatments available for skin rejuvenation and scar minimization. Laser-assisted drug delivery (LADD) is a treatment method that increases drug delivery by stimulating the skin physically and chemically to enhance the penetration of topical agents. This is one of the areas of great interest in the treatment of various skin diseases in addition to its use for cosmetic purposes. In particular, LADD is relatively non-invasive and has advantages in terms of accessibility and stability. Poly-L-lactic acid (PLLA) is a collagen stimulator known to gradually restore skin volume by inducing inflammation and fibroplasia. Herein, we report a case of treatment of an atrophic scar with fractional carbon dioxide laser-assisted PLLA delivery.

키워드

참고문헌

  1. Alegre-Sanchez A, Jimenez-Gomez N, Boixeda P. Laser-assisted drug delivery. Actas Dermosifiliogr (Engl Ed) 2018;109:858-67. https://doi.org/10.1016/j.ad.2018.07.008
  2. Badran KW, Nabili V. Lasers, microneedling, and platelet-rich plasma for skin rejuvenation and repair. Facial Plast Surg Clin North Am 2018;26:455-68. https://doi.org/10.1016/j.fsc.2018.06.007
  3. Ibrahim O, Wenande E, Hogan S, Arndt KA, Haedersdal M, Dover JS. Challenges to laser-assisted drug delivery: applying theory to clinical practice. Lasers Surg Med 2018;50:20-7. https://doi.org/10.1002/lsm.22769
  4. Wenande E, Erlendsson AM, Haedersdal M. Opportunities for laser-assisted drug delivery in the treatment of cutaneous disorders. Semin Cutan Med Surg 2017;36:192-201. https://doi.org/10.12788/j.sder.2017.046
  5. Waibel JS, Rudnick A, Shagalov DR, Nicolazzo DM. Update of ablative fractionated lasers to enhance cutaneous topical drug delivery. Adv Ther 2017;34:1840-9. https://doi.org/10.1007/s12325-017-0516-9
  6. Newberry CI, Thomas JR, Cerrati EW. Facial scar improvement procedures. Facial Plast Surg 2018;34:448-57. https://doi.org/10.1055/s-0038-1669400
  7. McIlwee BE, Alster TS. Laser skin resurfacing: cosmetic and medical applications. In: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, et al., editors. Fitzpatrick's Dermatology. 9th ed. New York: McGraw-Hill; 2019. p.3834-45.
  8. Spicer MS, Goldberg DJ. Lasers in dermatology. J Am Acad Dermatol 1996;34:1-25; quiz 26-8. https://doi.org/10.1016/S0190-9622(96)90827-0
  9. Tanzi EL, Lupton JR, Alster TS. Lasers in dermatology: four decades of progress. J Am Acad Dermatol 2003;49:1-31; quiz 31-4. https://doi.org/10.1067/mjd.2003.582
  10. Manstein D, Herron GS, Sink RK, Tanner H, Anderson RR. Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med 2004;34:426-38. https://doi.org/10.1002/lsm.20048
  11. Waibel JS, Wulkan AJ, Shumaker PR. Treatment of hypertrophic scars using laser and laser assisted corticosteroid delivery. Lasers Surg Med 2013;45:135-40. https://doi.org/10.1002/lsm.22120
  12. Rkein A, Ozog D, Waibel JS. Treatment of atrophic scars with fractionated CO2 laser facilitating delivery of topically applied poly-L-lactic acid. Dermatol Surg 2014;40:624-31.
  13. Fitzgerald R, Bass LM, Goldberg DJ, Graivier MH, Lorenc ZP. Physiochemical characteristics of poly-l-lactic acid (PLLA). Aesthet Surg J 2018;38(suppl_1):S13-7. https://doi.org/10.1093/asj/sjy012
  14. Ibrahim O, Ionta S, Depina J, Petrell K, Arndt KA, Dover JS. Safety of laser-assisted delivery of topical poly-l-lactic acid in the treatment of upper lip rhytides: a prospective, rater-blinded study. Dermatol Surg 2019;45:968-74. https://doi.org/10.1097/DSS.0000000000001743
  15. Lemperle G, Morhenn VB, Pestonjamasp V, Gallo RL. Migration studies and histology of injectable microspheres of different sizes in mice. Plast Reconstr Surg 2004;113:1380-90. https://doi.org/10.1097/01.PRS.0000112764.22839.7A