DOI QR코드

DOI QR Code

Hair Loss Treatment Using Erbium:YAG Fractional Laser with Hair Growth-promoting Solution

  • Received : 2021.07.14
  • Accepted : 2021.08.06
  • Published : 2021.09.30

Abstract

Several methods have been used to treat androgenetic hair loss, ranging from hair transplants to finasteride and minoxidil. Sometimes platelet-rich plasma injection therapy may be used to increase the satisfaction of patients who come to the hospital. However, some patients are sensitive to pain and are subjected to the inconvenience of requiring treatment after each blood sampling. The author had reported the effects of using a hair growth-promoting solution and JetpeelTM in parallel with a painless hair loss treatment method. However, the author was interested in more effective methods for patients with M-shaped or vertex hair loss who do not want to take medications or undergo hair transplant. In addition to the existing light-emitting diode therapy and electromagnetic field treatment, the author has made considered attempts to use various laser wavelength bands. However, the equipment for these methods can be expensive and are not suitable for patients who emphasize on cost-effectiveness. Therefore, the author used an existing reported method and a device based on the fractional erbium:YAG laser to provide the hair growth-promoting solution in parallel. The author chose a fractional 2940 nm-based laser device as a medium that could efficiently increase the growth phase, reduce the catagen phase, and facilitate intradermal product and drug delivery. As a result, there was a therapeutic benefit without any significant side effects such as redness and itching. Among the patients, the author reported the effects of the treatment on one patient with frontal M-shaped, mid, and vertex hair loss.

Keywords

References

  1. Perper M, Aldahan AS, Fayne RA, Emerson CP, Nouri K. Efficacy of fractional lasers in treating alopecia: a literature review. Lasers Med Sci 2017;32:1919-25. https://doi.org/10.1007/s10103-017-2306-7
  2. Ke J, Guan H, Li S, Xu L, Zhang L, Yan Y. Erbium: YAG laser (2,940 nm) treatment stimulates hair growth through upregulating Wnt 10b and β-catenin expression in C57BL/6 mice. Int J Clin Exp Med 2015;8:20883-9.
  3. Cho S, Choi MJ, Zheng Z, Goo B, Kim DY, Cho SB. Clinical effects of non-ablative and ablative fractional lasers on various hair disorders: a case series of 17 patients. J Cosmet Laser Ther 2013;15:74-9. https://doi.org/10.3109/14764172.2013.764436
  4. Lin CH, Aljuffali IA, Fang JY. Lasers as an approach for promoting drug delivery via skin. Expert Opin Drug Deliv 2014;11:599-614. https://doi.org/10.1517/17425247.2014.885501
  5. Gou S, Del Rio-Sancho S, Singhal M, Laubach HJ, Kalia YN. Er:YAG fractional laser ablation for cutaneous co-delivery of pentoxifylline and d-α-tocopherol succinate: a new approach for topical treatment of radiation-induced skin fibrosis. Eur J Pharm Sci 2019;135:22-31. https://doi.org/10.1016/j.ejps.2019.05.007
  6. Yu J, Dubey S, Kalia YN. Needle-free cutaneous delivery of living human cells by Er:YAG fractional laser ablation. Expert Opin Drug Deliv 2018;15:559-66. https://doi.org/10.1080/17425247.2018.1472570
  7. Bachhav YG, Heinrich A, Kalia YN. Controlled intra- and transdermal protein delivery using a minimally invasive Erbium:YAG fractional laser ablation technology. Eur J Pharm Biopharm 2013;84:355-64. https://doi.org/10.1016/j.ejpb.2012.11.018
  8. Song Y, Hemmady K, Puri A, Banga AK. Transdermal delivery of human growth hormone via laser-generated micropores. Drug Deliv Transl Res 2018;8:450-60. https://doi.org/10.1007/s13346-017-0370-y
  9. Ahn DH, Kang I. Transdermal delivery of a new hair growth promoting solution in patients with hair loss. Int J Case Rep Images 2019;10:101016Z01DA2019.
  10. Parhi R, Mandru A. Enhancement of skin permeability with thermal ablation techniques: concept to commercial products. Drug Deliv Transl Res 2021;11:817-41. https://doi.org/10.1007/s13346-020-00823-3
  11. Gentile P, Garcovich S. Advances in regenerative stem cell therapy in androgenic alopecia and hair loss: Wnt pathway, growth-factor, and mesenchymal stem cell signaling impact analysis on cell growth and hair follicle development. Cells 2019;8:466. https://doi.org/10.3390/cells8050466
  12. Li Z, Zhang J, Li M, Tang L, Liu H. Concentrated nanofat: a modified fat extraction promotes hair growth in mice via the stem cells and extracellular matrix components interaction. Ann Transl Med 2020;8:1184. https://doi.org/10.21037/atm-20-6086