Medical Lasers

  • 제10권4호
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  • Pages.195-200
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  • 2021
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  • 2287-8300(pISSN)
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  • 2288-0224(eISSN)
대한의학레이저학회 (Korean Society for Laser Medicine and Surgery)
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DOI QR코드

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Proposed Mechanisms of Photobiomodulation (PBM) Mediated via the Stimulation of Mitochondrial Activity in Peripheral Nerve Injuries

  • Choi, Ji Eun (Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University Hospital)
  • 투고 : 2021.08.02
  • 심사 : 2021.09.24
  • 발행 : 2021.12.31
⟨ 이전 논문 다음 논문 ⟩

초록

Evidence shows that nerve injury triggers mitochondrial dysfunction during axonal degeneration. Mitochondria play a pivotal role in axonal regeneration. Therefore, normalizing mitochondrial energy metabolism may represent an elective therapeutic strategy contributing to nerve recovery after damage. Photobiomodulation (PBM) induces a photobiological effect by stimulating mitochondrial activity. An increasing body of evidence demonstrates that PBM improves ATP generation and modulates many of the secondary mediators [reactive oxygen species (ROS), nitric oxide (NO), cyclic adenosine monophosphate (cAMP), and calcium ions (Ca2+)], which in turn activate multiple pathways involved in axonal regeneration.

키워드

과제정보

This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (no. NRF-2020R1C1C1009849).

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