DOI QR코드

DOI QR Code

Systemic Manifestations of Immunoglobulin G4-Related Disease: A Pictorial Essay

다양한 인체 장기에서 보일 수 있는 면역글로불린 G4 관련 질환: 임상화보

  • Kyungri Park (Departments of Radiology, Hanyang University College of Medicine, Hanyang University Hospital) ;
  • Yo Won Choi (Departments of Radiology, Hanyang University College of Medicine, Hanyang University Hospital) ;
  • Bo-Kyeong Kang (Departments of Radiology, Hanyang University College of Medicine, Hanyang University Hospital) ;
  • Ji Young Lee (Departments of Radiology, Hanyang University College of Medicine, Hanyang University Hospital) ;
  • Jeong Seon Park (Departments of Radiology, Hanyang University College of Medicine, Hanyang University Hospital) ;
  • Su-Jin Shin (Departments of Pathology, Hanyang University College of Medicine, Hanyang University Hospital) ;
  • Hye Ryoung Koo (Departments of Radiology, Hanyang University College of Medicine, Hanyang University Hospital)
  • 박경리 (한양대학교 의과대학 한양대학교병원 영상의학과) ;
  • 최요원 (한양대학교 의과대학 한양대학교병원 영상의학과) ;
  • 강보경 (한양대학교 의과대학 한양대학교병원 영상의학과) ;
  • 이지영 (한양대학교 의과대학 한양대학교병원 영상의학과) ;
  • 박정선 (한양대학교 의과대학 한양대학교병원 영상의학과) ;
  • 신수진 (한양대학교 의과대학 한양대학교병원 병리과) ;
  • 구혜령 (한양대학교 의과대학 한양대학교병원 영상의학과)
  • Received : 2020.07.28
  • Accepted : 2020.09.30
  • Published : 2021.05.01

Abstract

Immunoglobulin G4 (IgG4)-related disease is a systemic fibro-inflammatory disease characterized by pathologic findings in various organs. Imaging is critical for the diagnosis and treatment assessment of patients with IgG4-related disease. In this pictorial essay, we review the key features of multiple imaging modalities, typical pathologic findings, and differential diagnosis of IgG4-related disease. This systematic pictorial review can further our understanding of the broad-spectrum manifestations of this disease.

면역글로불린 G4 (immunoglobulin G4; 이하 IgG4) 관련 질환은 특징적인 병리 소견을 동반한 섬유화를 일으키는 전신 염증성 질환이다. 영상검사는 IgG4 관련 질환의 진단 및 치료 반응 평가에 필수적이다. 본 임상화보는 IgG4 관련 질환의 다양한 임상 증례를 통해 영상 소견 및 감별진단을 제시함으로써 IgG4 관련 질환에 대한 이해의 폭을 넓히고자 한다.

Keywords

References

  1. Sahani DV, Kalva SP, Farrell J, Maher MM, Saini S, Mueller PR, et al. Autoimmune pancreatitis: imaging features. Radiology 2004;233:345-352
  2. Irie H, Honda H, Baba S, Kuroiwa T, Yoshimitsu K, Tajima T, et al. Autoimmune pancreatitis: CT and MR characteristics. AJR Am J Roentgenol 1998;170:1323-1327 
  3. Muhi A, Ichikawa T, Motosugi U, Sou H, Sano K, Tsukamoto T, et al. Mass-forming autoimmune pancreatitis and pancreatic carcinoma: differential diagnosis on the basis of computed tomography and magnetic resonance cholangiopancreatography, and diffusion-weighted imaging findings. J Magn Reson Imaging 2012;35:827-836 
  4. Madhusudhan KS, Das P, Gunjan D, Srivastava DN, Garg PK. IgG4-related sclerosing cholangitis: a clinical and imaging review. AJR Am J Roentgenol 2019;213:1221-1231 
  5. Vaglio A, Salvarani C, Buzio C. Retroperitoneal fibrosis. Lancet 2006;367:241-251 
  6. Brun B, Laursen K, Sorensen IN, Lorentzen JE, Kristensen JK. CT in retroperitoneal fibrosis. AJR Am J Roentgenol 1981;137:535-538 
  7. Cronin CG, Lohan DG, Blake MA, Roche C, McCarthy P, Murphy JM. Retroperitoneal fibrosis: a review of clinical features and imaging findings. AJR Am J Roentgenol 2008;191:423-431 
  8. Bakir B, Yilmaz F, Turkay R, Ozel S, Bilgic B, Velioglu A, et al. Role of diffusion-weighted MR imaging in the differentiation of benign retroperitoneal fibrosis from malignant neoplasm: preliminary study. Radiology 2014;272:438-445 
  9. Arrive L, Hricak H, Tavares NJ, Miller TR. Malignant versus nonmalignant retroperitoneal fibrosis: differentiation with MR imaging. Radiology 1989;172:139-143 
  10. Rubenstein WA, Gray G, Auh YH, Honig CL, Thorbjarnarson B, Williams JJ, et al. CT of fibrous tissues and tumors with sonographic correlation. AJR Am J Roentgenol 1986;147:1067-1074 
  11. Takahashi N, Kawashima A, Fletcher JG, Chari ST. Renal involvement in patients with autoimmune pancreatitis: CT and MR imaging findings. Radiology 2007;242:791-801 
  12. Triantopoulou C, Malachias G, Maniatis P, Anastopoulos J, Siafas I, Papailiou J. Renal lesions associated with autoimmune pancreatitis: CT findings. Acta Radiol 2010;51:702-707 
  13. Kim B, Kim JH, Byun JH, Kim HJ, Lee SS, Kim SY, et al. IgG4-related kidney disease: MRI findings with emphasis on the usefulness of diffusion-weighted imaging. Eur J Radiol 2014;83:1057-1062 
  14. Inoue D, Zen Y, Abo H, Gabata T, Demachi H, Kobayashi T, et al. Immunoglobulin G4-related lung disease: CT findings with pathologic correlations. Radiology 2009;251:260-270 
  15. Ryu JH, Sekiguchi H, Yi ES. Pulmonary manifestations of immunoglobulin G4-related sclerosing disease. Eur Respir J 2012;39:180-186 
  16. Geyer JT, Ferry JA, Harris NL, Stone JH, Zukerberg LR, Lauwers GY, et al. Chronic sclerosing sialadenitis (Kuttner tumor) is an IgG4-associated disease. Am J Surg Pathol 2010;34:202-210 
  17. Yamamoto M, Takahashi H, Ohara M, Suzuki C, Naishiro Y, Yamamoto H, et al. A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic disease. Mod Rheumatol 2006;16:335-340 
  18. Tiegs-Heiden CA, Eckel LJ, Hunt CH, Diehn FE, Schwartz KM, Kallmes DF, et al. Immunoglobulin G4-related disease of the orbit: imaging features in 27 patients. AJNR Am J Neuroradiol 2014;35:1393-1397 
  19. Zalaquett E, Razmilic D, Oddo D. Immunoglobulin G4-related sclerosing mastitis: AIRP best cases in radiologic-pathologic correlation. Radiographics 2016;36:959-962 
  20. Cheuk W, Yuen HK, Chu SY, Chiu EK, Lam LK, Chan JK. Lymphadenopathy of IgG4-related sclerosing disease. Am J Surg Pathol 2008;32:671-681 
  21. Lu LX, Della-Torre E, Stone JH, Clark SW. IgG4-related hypertrophic pachymeningitis: clinical features, diagnostic criteria, and treatment. JAMA Neurol 2014;71:785-793