Acknowledgement
This research was supported by the National Research Foundation of Korea (NRF) grants funded by Ministry of Science and ICT (MSIT) - grant No. 2020R1A2C2008312 and 2020R1A4A1017515.
References
- Antoniu, S.A., Rajnoveanu, R., Grigore, M., and Antohe, I. (2020). Pharmacotherapy options in pulmonary alveolar proteinosis. Expert Opin. Pharmacother. 21, 1359-1366. https://doi.org/10.1080/14656566.2020.1757650
- Bazewicz, C.G., Dinavahi, S.S., Schell, T.D., and Robertson, G.P. (2019). Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer. Immunology 156, 47-55. https://doi.org/10.1111/imm.13016
- Belchamber, K.B.R. and Donnelly, L.E. (2017). Macrophage dysfunction in respiratory disease. Results Probl. Cell Differ. 62, 299-313. https://doi.org/10.1007/978-3-319-54090-0_12
- Bhavsar, P.K., Levy, B.D., Hew, M.J., Pfeffer, M.A., Kazani, S., Israel, E., and Chung, K.F. (2010). Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma. Respir. Res. 11, 71. https://doi.org/10.1186/1465-9921-11-71
- Bissonnette, E.Y., Lauzon-Joset, J.F., Debley, J.S., and Ziegler, S.F. (2020). Cross-talk between alveolar macrophages and lung epithelial cells is essential to maintain lung homeostasis. Front. Immunol. 11, 583042. https://doi.org/10.3389/fimmu.2020.583042
- Canton, J., Neculai, D., and Grinstein, S. (2013). Scavenger receptors in homeostasis and immunity. Nat. Rev. Immunol. 13, 621-634. https://doi.org/10.1038/nri3515
- Chavis, C., Godard, P., Michel, F.B., Crastes de Paulet, A., and Damon, M. (1991). Sulfidopeptide leukotrienes contribute to human alveolar macrophage activation in asthma. Prostaglandins Leukot. Essent. Fatty Acids 42, 95-100. https://doi.org/10.1016/0952-3278(91)90074-F
- Chen, H., Cowan, M.J., Hasday, J.D., Vogel, S.N., and Medvedev, A.E. (2007). Tobacco smoking inhibits expression of proinflammatory cytokines and activation of IL-1R-associated kinase, p38, and NF-kappaB in alveolar macrophages stimulated with TLR2 and TLR4 agonists. J. Immunol. 179, 6097-6106. https://doi.org/10.4049/jimmunol.179.9.6097
- Coleman, M.M., Ruane, D., Moran, B., Dunne, P.J., Keane, J., and Mills, K.H. (2013). Alveolar macrophages contribute to respiratory tolerance by inducing FoxP3 expression in naive T cells. Am. J. Respir. Cell Mol. Biol. 48, 773-780. https://doi.org/10.1165/rcmb.2012-0263OC
- Damon, M., Chavis, C., Daures, J.P., Crastes de Paulet, A., Michel, F.B., and Godard, P. (1989). Increased generation of the arachidonic metabolites LTB4 and 5-HETE by human alveolar macrophages in patients with asthma: effect in vitro of nedocromil sodium. Eur. Respir. J. 2, 202-209.
- Davies, L.C., Jenkins, S.J., Allen, J.E., and Taylor, P.R. (2013). Tissue-resident macrophages. Nat. Immunol. 14, 986-995. https://doi.org/10.1038/ni.2705
- Deng, W., Yang, J., Lin, X., Shin, J., Gao, J., and Zhong, X.P. (2017). Essential role of mTORC1 in self-renewal of murine alveolar macrophages. J. Immunol. 198, 492-504. https://doi.org/10.4049/jimmunol.1501845
- Draijer, C., Penke, L.R.K., and Peters-Golden, M. (2019). Distinctive effects of GM-CSF and M-CSF on proliferation and polarization of two major pulmonary macrophage populations. J. Immunol. 202, 2700-2709. https://doi.org/10.4049/jimmunol.1801387
- Duan, M., Hibbs, M.L., and Chen, W. (2017). The contributions of lung macrophage and monocyte heterogeneity to influenza pathogenesis. Immunol. Cell Biol. 95, 225-235. https://doi.org/10.1038/icb.2016.97
- Elliott, M.R., Koster, K.M., and Murphy, P.S. (2017). Efferocytosis signaling in the regulation of macrophage inflammatory responses. J. Immunol. 198, 1387-1394. https://doi.org/10.4049/jimmunol.1601520
- Fadok, V.A., Bratton, D.L., Konowal, A., Freed, P.W., Westcott, J.Y., and Henson, P.M. (1998). Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J. Clin. Invest. 101, 890-898. https://doi.org/10.1172/JCI1112
- Fernandez, S., Jose, P., Avdiushko, M.G., Kaplan, A.M., and Cohen, D.A. (2004). Inhibition of IL-10 receptor function in alveolar macrophages by Toll-like receptor agonists. J. Immunol. 172, 2613-2620. https://doi.org/10.4049/jimmunol.172.4.2613
- Fitzpatrick, A.M., Holguin, F., Teague, W.G., and Brown, L.A. (2008). Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma. J. Allergy Clin. Immunol. 121, 1372-1378.e1-3. https://doi.org/10.1016/j.jaci.2008.03.008
- Fujii, T., Hayashi, S., Hogg, J.C., Mukae, H., Suwa, T., Goto, Y., Vincent, R., and van Eeden, S.F. (2002). Interaction of alveolar macrophages and airway epithelial cells following exposure to particulate matter produces mediators that stimulate the bone marrow. Am. J. Respir. Cell Mol. Biol. 27, 34-41. https://doi.org/10.1165/ajrcmb.27.1.4787
- Gao, X., Dong, Y., Liu, Z., and Niu, B. (2013). Silencing of triggering receptor expressed on myeloid cells-2 enhances the inflammatory responses of alveolar macrophages to lipopolysaccharide. Mol. Med. Rep. 7, 921-926. https://doi.org/10.3892/mmr.2013.1268
- Gentek, R., Molawi, K., and Sieweke, M.H. (2014). Tissue macrophage identity and self-renewal. Immunol. Rev. 262, 56-73. https://doi.org/10.1111/imr.12224
- Grabiec, A.M. and Hussell, T. (2016). The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation. Semin. Immunopathol. 38, 409-423. https://doi.org/10.1007/s00281-016-0555-3
- Gross, N.J. and Barnes, P.J. (2017). New therapies for asthma and chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 195, 159-166. https://doi.org/10.1164/rccm.201610-2074PP
- Guilliams, M., De Kleer, I., Henri, S., Post, S., Vanhoutte, L., De Prijck, S., Deswarte, K., Malissen, B., Hammad, H., and Lambrecht, B.N. (2013). Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF. J. Exp. Med. 210, 1977-1992. https://doi.org/10.1084/jem.20131199
- Guth, A.M., Janssen, W.J., Bosio, C.M., Crouch, E.C., Henson, P.M., and Dow, S.W. (2009). Lung environment determines unique phenotype of alveolar macrophages. Am. J. Physiol. Lung Cell. Mol. Physiol. 296, L936-L946. https://doi.org/10.1152/ajplung.90625.2008
- Han, J., Hajjar, D.P., Tauras, J.M., Feng, J., Gotto, A.M., Jr., and Nicholson, A.C. (2000). Transforming growth factor-beta1 (TGF-beta1) and TGF-beta2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-gamma. J. Biol. Chem. 275, 1241-1246. https://doi.org/10.1074/jbc.275.2.1241
- Han, K.H., Tangirala, R.K., Green, S.R., and Quehenberger, O. (1998). Chemokine receptor CCR2 expression and monocyte chemoattractant protein-1-mediated chemotaxis in human monocytes. A regulatory role for plasma LDL. Arterioscler. Thromb. Vasc. Biol. 18, 1983-1991. https://doi.org/10.1161/01.ATV.18.12.1983
- Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M.B., Leboeuf, M., Becker, C.D., See, P., Price, J., Lucas, D., et al. (2013). Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 38, 792-804. https://doi.org/10.1016/j.immuni.2013.04.004
- Haslett, C. (1999). Granulocyte apoptosis and its role in the resolution and control of lung inflammation. Am. J. Respir. Crit. Care Med. 160(5 Pt 2), S5-S11. https://doi.org/10.1164/ajrccm.160.supplement_1.4
- Hercus, T.R., Broughton, S.E., Ekert, P.G., Ramshaw, H.S., Perugini, M., Grimbaldeston, M., Woodcock, J.M., Thomas, D., Pitson, S., Hughes, T., et al. (2012). The GM-CSF receptor family: mechanism of activation and implications for disease. Growth Factors 30, 63-75. https://doi.org/10.3109/08977194.2011.649919
- Hercus, T.R., Thomas, D., Guthridge, M.A., Ekert, P.G., King-Scott, J., Parker, M.W., and Lopez, A.F. (2009). The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease. Blood 114, 1289-1298.
- Hindelang, M., Kirsch, F., and Leidl, R. (2020). Effectiveness of nonpharmacological COPD management on health-related quality of life - a systematic review. Expert Rev. Pharmacoecon. Outcomes Res. 20, 79-91. https://doi.org/10.1080/14737167.2020.1734455
- Hodge, M.X., Reece, S.W., Madenspacher, J.H., and Gowdy, K.M. (2019). In vivo assessment of alveolar macrophage efferocytosis following ozone exposure. J. Vis. Exp. (152), e60109.
- Hodge, S., Hodge, G., Scicchitano, R., Reynolds, P.N., and Holmes, M. (2003). Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells. Immunol. Cell Biol. 81, 289-296. https://doi.org/10.1046/j.1440-1711.2003.t01-1-01170.x
- Hoeffel, G., Chen, J., Lavin, Y., Low, D., Almeida, F.F., See, P., Beaudin, A.E., Lum, J., Low, I., Forsberg, E.C., et al. (2015). C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. Immunity 42, 665-678. https://doi.org/10.1016/j.immuni.2015.03.011
- Hoeffel, G. and Ginhoux, F. (2018). Fetal monocytes and the origins of tissue-resident macrophages. Cell. Immunol. 330, 5-15. https://doi.org/10.1016/j.cellimm.2018.01.001
- Huang, L., Nazarova, E.V., Tan, S., Liu, Y., and Russell, D.G. (2018). Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny. J. Exp. Med. 215, 1135-1152. https://doi.org/10.1084/jem.20172020
- Huang, X., Xiu, H., Zhang, S., and Zhang, G. (2018). The role of macrophages in the pathogenesis of ALI/ARDS. Mediators Inflamm. 2018, 1264913. https://doi.org/10.1155/2018/1264913
- Huffman Reed, J.A., Rice, W.R., Zsengeller, Z.K., Wert, S.E., Dranoff, G., and Whitsett, J.A. (1997). GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice. Am. J. Physiol. 273, L715-L725.
- Huynh, M.L., Fadok, V.A., and Henson, P.M. (2002). Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J. Clin. Invest. 109, 41-50. https://doi.org/10.1172/JCI0211638
- Huynh, M.L., Malcolm, K.C., Kotaru, C., Tilstra, J.A., Westcott, J.Y., Fadok, V.A., and Wenzel, S.E. (2005). Defective apoptotic cell phagocytosis attenuates prostaglandin E2 and 15-hydroxyeicosatetraenoic acid in severe asthma alveolar macrophages. Am. J. Respir. Crit. Care Med. 172, 972-979. https://doi.org/10.1164/rccm.200501-035OC
- Kaur, M., Bell, T., Salek-Ardakani, S., and Hussell, T. (2015). Macrophage adaptation in airway inflammatory resolution. Eur. Respir. Rev. 24, 510-515. https://doi.org/10.1183/16000617.0030-2015
- Kawai, T. and Akira, S. (2010). The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11, 373-384. https://doi.org/10.1038/ni.1863
- Kim, K.K., Dotson, M.R., Agarwal, M., Yang, J., Bradley, P.B., Subbotina, N., Osterholzer, J.J., and Sisson, T.H. (2018). Efferocytosis of apoptotic alveolar epithelial cells is sufficient to initiate lung fibrosis. Cell Death Dis. 9, 1056. https://doi.org/10.1038/s41419-018-1074-z
- Koning, N., van Eijk, M., Pouwels, W., Brouwer, M.S., Voehringer, D., Huitinga, I., Hoek, R.M., Raes, G., and Hamann, J. (2010). Expression of the inhibitory CD200 receptor is associated with alternative macrophage activation. J. Innate Immun. 2, 195-200. https://doi.org/10.1159/000252803
- Krenkel, O., Puengel, T., Govaere, O., Abdallah, A.T., Mossanen, J.C., Kohlhepp, M., Liepelt, A., Lefebvre, E., Luedde, T., Hellerbrand, C., et al. (2018). Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis. Hepatology 67, 1270-1283. https://doi.org/10.1002/hep.29544
- Krysko, D.V., D'Herde, K., and Vandenabeele, P. (2006). Clearance of apoptotic and necrotic cells and its immunological consequences. Apoptosis 11, 1709-1726. https://doi.org/10.1007/s10495-006-9527-8
- Lavin, Y., Mortha, A., Rahman, A., and Merad, M. (2015). Regulation of macrophage development and function in peripheral tissues. Nat. Rev. Immunol. 15, 731-744. https://doi.org/10.1038/nri3920
- Li, G., Jin, F., Du, J., He, Q., Yang, B., and Luo, P. (2019). Macrophage-secreted TSLP and MMP9 promote bleomycin-induced pulmonary fibrosis. Toxicol. Appl. Pharmacol. 366, 10-16. https://doi.org/10.1016/j.taap.2019.01.011
- Machiels, B., Dourcy, M., Xiao, X., Javaux, J., Mesnil, C., Sabatel, C., Desmecht, D., Lallemand, F., Martinive, P., Hammad, H., et al. (2017). A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes. Nat. Immunol. 18, 1310-1320. https://doi.org/10.1038/ni.3857
- Malur, A., Kavuru, M.S., Marshall, I., Barna, B.P., Huizar, I., Karnekar, R., and Thomassen, M.J. (2012). Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis. Respir. Res. 13, 46. https://doi.org/10.1186/1465-9921-13-46
- Mariencheck, W.I., Savov, J., Dong, Q., Tino, M.J., and Wright, J.R. (1999). Surfactant protein A enhances alveolar macrophage phagocytosis of a live, mucoid strain of P. aeruginosa. Am. J. Physiol. 277, L777-L786.
- Mayer, A.K., Bartz, H., Fey, F., Schmidt, L.M., and Dalpke, A.H. (2008). Airway epithelial cells modify immune responses by inducing an antiinflammatory microenvironment. Eur. J. Immunol. 38, 1689-1699. https://doi.org/10.1002/eji.200737936
- McCarthy, C., Lee, E., Bridges, J.P., Sallese, A., Suzuki, T., Woods, J.C., Bartholmai, B.J., Wang, T., Chalk, C., Carey, B.C., et al. (2018). Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis. Nat. Commun. 9, 3127. https://doi.org/10.1038/s41467-018-05491-z
- Misharin, A.V., Morales-Nebreda, L., Reyfman, P.A., Cuda, C.M., Walter, J.M., McQuattie-Pimentel, A.C., Chen, C.I., Anekalla, K.R., Joshi, N., Williams, K., et al. (2017). Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. J. Exp. Med. 214, 2387-2404. https://doi.org/10.1084/jem.20162152
- Mohning, M.P., Thomas, S.M., Barthel, L., Mould, K.J., McCubbrey, A.L., Frasch, S.C., Bratton, D.L., Henson, P.M., and Janssen, W.J. (2018). Phagocytosis of microparticles by alveolar macrophages during acute lung injury requires MerTK. Am. J. Physiol. Lung Cell. Mol. Physiol. 314, L69-L82. https://doi.org/10.1152/ajplung.00058.2017
- Moon, H.G., Cao, Y., Yang, J., Lee, J.H., Choi, H.S., and Jin, Y. (2015). Lung epithelial cell-derived extracellular vesicles activate macrophage-mediated inflammatory responses via ROCK1 pathway. Cell Death Dis. 6, e2016. https://doi.org/10.1038/cddis.2015.282
- Nagre, N., Cong, X., Pearson, A.C., and Zhao, X. (2019). Alveolar macrophage phagocytosis and bacteria clearance in mice. J. Vis. Exp. (145), e59088.
- Nishinakamura, R., Wiler, R., Dirksen, U., Morikawa, Y., Arai, K., Miyajima, A., Burdach, S., and Murray, R. (1996). The pulmonary alveolar proteinosis in granulocyte macrophage colony-stimulating factor/interleukins 3/5 beta c receptor-deficient mice is reversed by bone marrow transplantation. J. Exp. Med. 183, 2657-2662. https://doi.org/10.1084/jem.183.6.2657
- O'Beirne, S.L., Kikkers, S.A., Oromendia, C., Salit, J., Rostmai, M.R., Ballman, K.V., Kaner, R.J., Crystal, R.G., and Cloonan, S.M. (2020). Alveolar macrophage immunometabolism and lung function impairment in smoking and chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 201, 735-739. https://doi.org/10.1164/rccm.201908-1683LE
- Ortega-Gomez, A., Perretti, M., and Soehnlein, O. (2013). Resolution of inflammation: an integrated view. EMBO Mol. Med. 5, 661-674. https://doi.org/10.1002/emmm.201202382
- Pearce, E.L. and Pearce, E.J. (2013). Metabolic pathways in immune cell activation and quiescence. Immunity 38, 633-643. https://doi.org/10.1016/j.immuni.2013.04.005
- Ramirez, A., Ballard, E.N., and Roman, J. (2012). TGFbeta1 controls PPARgamma expression, transcriptional potential, and activity, in part, through Smad3 signaling in murine lung fibroblasts. PPAR Res. 2012, 375876. https://doi.org/10.1155/2012/375876
- Rubins, J.B. (2003). Alveolar macrophages: wielding the double-edged sword of inflammation. Am. J. Respir. Crit. Care Med. 167, 103-104. https://doi.org/10.1164/rccm.2210007
- Sallese, A., Suzuki, T., McCarthy, C., Bridges, J., Filuta, A., Arumugam, P., Shima, K., Ma, Y., Wessendarp, M., Black, D., et al. (2017). Targeting cholesterol homeostasis in lung diseases. Sci. Rep. 7, 10211. https://doi.org/10.1038/s41598-017-10879-w
- Saxton, R.A. and Sabatini, D.M. (2017). mTOR signaling in growth, metabolism, and disease. Cell 169, 361-371. https://doi.org/10.1016/j.cell.2017.03.035
- Schagat, T.L., Wofford, J.A., and Wright, J.R. (2001). Surfactant protein A enhances alveolar macrophage phagocytosis of apoptotic neutrophils. J. Immunol. 166, 2727-2733. https://doi.org/10.4049/jimmunol.166.4.2727
- Schneider, C., Nobs, S.P., Kurrer, M., Rehrauer, H., Thiele, C., and Kopf, M. (2014). Induction of the nuclear receptor PPAR-gamma by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages. Nat. Immunol. 15, 1026-1037. https://doi.org/10.1038/ni.3005
- Sinclair, C., Bommakanti, G., Gardinassi, L., Loebbermann, J., Johnson, M.J., Hakimpour, P., Hagan, T., Benitez, L., Todor, A., Machiah, D., et al. (2017). mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation. Science 357, 1014-1021. https://doi.org/10.1126/science.aaj2155
- Song, C., Li, H., Li, Y., Dai, M., Zhang, L., Liu, S., Tan, H., Deng, P., Liu, J., Mao, Z., et al. (2019). NETs promote ALI/ARDS inflammation by regulating alveolar macrophage polarization. Exp. Cell Res. 382, 111486. https://doi.org/10.1016/j.yexcr.2019.06.031
- Soni, S., Wilson, M.R., O'Dea, K.P., Yoshida, M., Katbeh, U., Woods, S.J., and Takata, M. (2016). Alveolar macrophage-derived microvesicles mediate acute lung injury. Thorax 71, 1020-1029. https://doi.org/10.1136/thoraxjnl-2015-208032
- Soroosh, P., Doherty, T.A., Duan, W., Mehta, A.K., Choi, H., Adams, Y.F., Mikulski, Z., Khorram, N., Rosenthal, P., Broide, D.H., et al. (2013). Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance. J. Exp. Med. 210, 775-788. https://doi.org/10.1084/jem.20121849
- Stanley, E., Lieschke, G.J., Grail, D., Metcalf, D., Hodgson, G., Gall, J.A., Maher, D.W., Cebon, J., Sinickas, V., and Dunn, A.R. (1994). Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc. Natl. Acad. Sci. U. S. A. 91, 5592-5596. https://doi.org/10.1073/pnas.91.12.5592
- Steele, C., Marrero, L., Swain, S., Harmsen, A.G., Zheng, M., Brown, G.D., Gordon, S., Shellito, J.E., and Kolls, J.K. (2003). Alveolar macrophage-mediated killing of Pneumocystis carinii f. sp. muris involves molecular recognition by the Dectin-1 beta-glucan receptor. J. Exp. Med. 198, 1677-1688. https://doi.org/10.1084/jem.20030932
- Sugiyama, D., Inoue-Yokoo, T., Fraser, S.T., Kulkeaw, K., Mizuochi, C., and Horio, Y. (2011). Embryonic regulation of the mouse hematopoietic niche. ScientificWorldJournal 11, 1770-1780. https://doi.org/10.1100/2011/598097
- Sun, W., Wei, F.Q., Li, W.J., Wei, J.W., Zhong, H., Wen, Y.H., Lei, W.B., Chen, L., Li, H., Lin, H.Q., et al. (2017). A positive-feedback loop between tumour infiltrating activated Treg cells and type 2-skewed macrophages is essential for progression of laryngeal squamous cell carcinoma. Br. J. Cancer 117, 1631-1643. https://doi.org/10.1038/bjc.2017.329
- Tan, S.Y. and Krasnow, M.A. (2016). Developmental origin of lung macrophage diversity. Development 143, 1318-1327. https://doi.org/10.1242/dev.129122
- Thomassen, M.J., Barna, B.P., Malur, A.G., Bonfield, T.L., Farver, C.F., Malur, A., Dalrymple, H., Kavuru, M.S., and Febbraio, M. (2007). ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis. J. Lipid Res. 48, 2762-2768. https://doi.org/10.1194/jlr.P700022-JLR200
- Tsai, C.F., Chen, J.H., and Yeh, W.L. (2019). Pulmonary fibroblasts-secreted CXCL10 polarizes alveolar macrophages under pro-inflammatory stimuli. Toxicol. Appl. Pharmacol. 380, 114698. https://doi.org/10.1016/j.taap.2019.114698
- Ushach, I. and Zlotnik, A. (2016). Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage. J. Leukoc. Biol. 100, 481-489. https://doi.org/10.1189/jlb.3RU0316-144R
- van de Laar, L., Saelens, W., De Prijck, S., Martens, L., Scott, C.L., Van Isterdael, G., Hoffmann, E., Beyaert, R., Saeys, Y., Lambrecht, B.N., et al. (2016). Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages. Immunity 44, 755-768. https://doi.org/10.1016/j.immuni.2016.02.017
- Viola, A., Munari, F., Sanchez-Rodriguez, R., Scolaro, T., and Castegna, A. (2019). The metabolic signature of macrophage responses. Front. Immunol. 10, 1462. https://doi.org/10.3389/fimmu.2019.01462
- Wilson, M.E., McCandless, E.E., Olszewski, M.A., and Robinson, N.E. (2020). Alveolar macrophage phenotypes in severe equine asthma. Vet. J. 256, 105436. https://doi.org/10.1016/j.tvjl.2020.105436
- Woo, Y.D., Koh, J., Ko, J.S., Kim, S., Jung, K.C., Jeon, Y.K., Kim, H.Y., Lee, H., Lee, C.W., and Chung, D.H. (2021). Ssu72 regulates alveolar macrophage development and allergic airway inflammation by fine-tuning of GM-CSF receptor signaling. J. Allergy Clin. Immunol. 147, 1242-1260. https://doi.org/10.1016/j.jaci.2020.07.038
- Woods, P.S., Kimmig, L.M., Meliton, A.Y., Sun, K.A., Tian, Y., O'Leary, E.M., Gokalp, G.A., Hamanaka, R.B., and Mutlu, G.M. (2020). Tissue-resident alveolar macrophages do not rely on glycolysis for LPS-induced inflammation. Am. J. Respir. Cell Mol. Biol. 62, 243-255. https://doi.org/10.1165/rcmb.2019-0244OC
- Wynn, T.A. and Vannella, K.M. (2016). Macrophages in tissue repair, regeneration, and fibrosis. Immunity 44, 450-462. https://doi.org/10.1016/j.immuni.2016.02.015
- Yamane, T. (2018). Mouse yolk sac hematopoiesis. Front. Cell Dev. Biol. 6, 80. https://doi.org/10.3389/fcell.2018.00080
- Yeligar, S.M., Chen, M.M., Kovacs, E.J., Sisson, J.H., Burnham, E.L., and Brown, L.A. (2016). Alcohol and lung injury and immunity. Alcohol 55, 51-59. https://doi.org/10.1016/j.alcohol.2016.08.005
- Yu, X., Buttgereit, A., Lelios, I., Utz, S.G., Cansever, D., Becher, B., and Greter, M. (2017). The cytokine TGF-beta promotes the development and homeostasis of alveolar macrophages. Immunity 47, 903-912.e4. https://doi.org/10.1016/j.immuni.2017.10.007
- Zhang, J., Tachado, S.D., Patel, N., Zhu, J., Imrich, A., Manfruelli, P., Cushion, M., Kinane, T.B., and Koziel, H. (2005). Negative regulatory role of mannose receptors on human alveolar macrophage proinflammatory cytokine release in vitro. J. Leukoc. Biol. 78, 665-674. https://doi.org/10.1189/jlb.1204699
- Zhang, W., Li, Q., Li, D., Li, J., Aki, D., and Liu, Y.C. (2018). The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation. J. Exp. Med. 215, 3180-3193. https://doi.org/10.1084/jem.20181211
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