IMMUNE NETWORK

  • 제21권2호
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  • Pages.15.1-15.10
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  • 2021
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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Modulation of Pro-inflammatory and Anti-inflammatory Cytokines in the Fat by an Aloe Gel-based Formula, QDMC, Is Correlated with Altered Gut Microbiota

  • Jinho An (College of Pharmacy, Sahmyook University) ;
  • Heetae Lee (College of Pharmacy, Sahmyook University) ;
  • Sungwon Lee (College of Pharmacy, Sahmyook University) ;
  • Youngcheon Song (College of Pharmacy, Sahmyook University) ;
  • Jiyeon Kim (Climacteric Natural Products Research Institute, Sahmyook University) ;
  • Il Ho Park (College of Pharmacy, Sahmyook University) ;
  • Hyunseok Kong (Climacteric Natural Products Research Institute, Sahmyook University) ;
  • Kyungjae Kim (College of Pharmacy, Sahmyook University)
  • 투고 : 2021.01.05
  • 심사 : 2021.02.17
  • 발행 : 2021.04.30
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초록

Abnormal inflammatory responses are closely associated with intestinal microbial dysbiosis. Oral administration of Qmatrix-diabetes-mellitus complex (QDMC), an Aloe gel-based formula, has been reported to improve inflammation in type 2 diabetic mice; however, the role of the gut microbiota in ameliorating efficacy of QDMC remains unclear. We investigated the effect of QDMC on the gut microbiota in a type 2 diabetic aged mouse model that was administered a high-fat diet. Proinflammatory (TNF-α and IL-6) and anti-inflammatory (IL-4 and IL-10) cytokine levels in the fat were normalized via oral administration of QDMC, and relative abundances of Bacteroides, Butyricimonas, Ruminococcus, and Mucispirillum were simultaneously significantly increased. The abundance of these bacteria was correlated to the expression levels of cytokines. Our findings suggest that the immunomodulatory activity of QDMC is partly mediated by the altered gut microbiota composition.

키워드

과제정보

This research was supported by the Sahmyook University Research Fund [RI12020003 (2020)] and we thank Univera, Inc for providing Aloe QDM complex.

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