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A case of motor and sensory polyneuropathy induced by primary hyperparathyroidism

  • Lee, Mina (Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine) ;
  • Kim, Hye Jeong (Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine) ;
  • Roh, Hakjae (Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine)
  • Received : 2021.08.02
  • Accepted : 2021.09.19
  • Published : 2021.10.31

Abstract

Primary hyperparathyroidism (PHP) is a disease in which excessive amounts of parathyroid hormone (PTH) are secreted and calcium levels in the blood increase. Hypercalcemia caused by PHP has a major influence on the peripheral nervous system and produces symptoms such as muscle cramps, paresthesia, and proximal muscle weakness. Here we report a rare case of sensory-dominant polyneuropathy caused by PHP, which improved after surgery.

Keywords

References

  1. Insogna KL. Primary Hyperparathyroidism. N Engl J Med 2018;379:1050-1059. https://doi.org/10.1056/NEJMcp1714213
  2. Marcocci C, Cetani F. Clinical practice. Primary hyperparathyroidism. N Engl J Med 2011;365:2389-2397. https://doi.org/10.1056/NEJMcp1106636
  3. Cogan MG, Covey CM, Arieff AI, Wisniewski A, Clark OH, Lazarowitz V, et al. Central nervous system manifestations of hyperparathyroidism. Am J Med 1978;65:963-970. https://doi.org/10.1016/0002-9343(78)90748-9
  4. Turken SA, Cafferty M, Silverberg SJ, De La Cruz L, Cimino C, Lange DJ, et al. Neuromuscular involvement in mild, asymptomatic primary hyperparathyroidism. Am J Med 1989;87:553-557. https://doi.org/10.1016/S0002-9343(89)80613-8
  5. Logullo F, Babbini MT, Di Bella P, Provinciali L. Reversible combined cognitive impairment and severe polyneuropathy resulting from primary hyperparathyroidism. Ital J Neurol Sci 1998;19:86-89. https://doi.org/10.1007/BF02427562
  6. Gentric A, Jezequel J, Pennec YL. Severe neuropathy related to primary hyperparathyroidism cured by parathyroidectomy. J Am Geriatr Soc 1993;41:759. https://doi.org/10.1111/j.1532-5415.1993.tb07468.x
  7. Delbridge LW, Marshman D, Reeve TS, Crummer P, Posen S. Neuromuscular symptoms in elderly patients with hyperparathyroidism: improvement with parathyroid surgery. Med J Aust 1988;149:74-76. https://doi.org/10.5694/j.1326-5377.1988.tb120508.x
  8. Diniz ET, Bandeira F, Lins OG, Cavalcanti EN, de Arruda TM, Januario AM, et al. Primary hyperparathyroidism is associated with subclinical peripheral neural alterations. Endocr Pract 2013;19:219-225. https://doi.org/10.4158/EP12207.OR
  9. Schlaepfer WW, Bunge RP. Effects of calcium ion concentration on the degeneration of amputated axons in tissue culture. J Cell Biol 1973;59(2 Pt 1):456-470. https://doi.org/10.1083/jcb.59.2.456