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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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The blood cerebrospinal fluid barrier orchestrates immunosurveillance, immunoprotection, and immunopathology in the central nervous system

  • Ayub, Maria (KNU Alzheimer's disease Research Institute, Kyungpook National University) ;
  • Jin, Hee Kyung (KNU Alzheimer's disease Research Institute, Kyungpook National University) ;
  • Bae, Jae-sung (KNU Alzheimer's disease Research Institute, Kyungpook National University)
  • Received : 2020.09.25
  • Accepted : 2020.11.23
  • Published : 2021.04.30
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Abstract

Once characterized as an immune privileged area, recent scientific advances have demonstrated that the central nervous system (CNS) is both immunologically active and a specialized site. The anatomical and cellular features of the brain barriers, the glia limitans, and other superficial coverings of the CNS endow the brain with specificity for immune cell entry and other macro- and micro-elements to the brain. Cellular trafficking via barriers comprised of tightly junctioned non-fenestrated endothelium or tightly regulated fenestrated epithelium results in different phenotypic and cellular changes in the brain, that is, inflammatory versus regulatory changes. Based on emerging evidence, we described the unique ability of the blood cerebrospinal fluid barrier (BCSFB) to recruit, skew, and suppress immune cells. Additionally, we sum up the current knowledge on both cellular and molecular mechanisms governed by the choroid plexus and the cerebrospinal fluid at the BCSFB for immunosurveillance, immunoprotection, and immunopathology.

Keywords

Acknowledgement

This research was supported by the Basic Science Research Program (2017R1A4A1015652, 2020R1A2C3006875, 2020R 1A2C3006734) of the NRF funded by the Korean government, MSIT.

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