Development and Reproduction (한국발생생물학회지:발생과생식)

The Korean Society of Developmental Biology (한국발생생물학회)
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Maternal Exposure to Bisphenol A Impacts on Fecundity in F1 and F2 Generations in Drosophila melanogaster

  • Kim, Sohee (Department of Pharmacology, Dong-A University College of Medicine) ;
  • Kang, Kyong-hwa (Department of Pharmacology, Dong-A University College of Medicine) ;
  • Koh, Hyongjong (Department of Pharmacology, Dong-A University College of Medicine)
  • Received : 2021.05.12
  • Accepted : 2021.08.16
  • Published : 2021.09.30
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Abstract

In previous reports, bisphenol A (BPA) exposure affects reproductive function in Drosophila melanogaster females. To test the maternal effect of BPA exposure on fly reproductive function, F0 mothers were exposed to 0, 0.1, 1, and 10 mg/L of BPA and the fecundity in F1 and F2 generations were checked. In this experiment, 1 and 10 mg/L BPA significantly decreased the fecundity of F1 females. Moreover, 0.1 and 1 mg/L BPA substantially reduced egg production in the F2 generation. These results suggested that maternal exposure to BPA at enviromentally relavant concnetrations reduces reproductive function in Drosophila melanogaster females and that this effect is transgenerational.

Keywords

Acknowledgement

This work was supported by grants from the National Research Foundation of Korea, funded by the Ministry of Science and ICT (Grant No.: 2020R1F1A105165912).

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