한국발생생물학회지:발생과생식 (Development and Reproduction)

  • 제25권4호
  • /
  • Pages.293-298
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  • 2021
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  • 2465-9525(pISSN)
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  • 2465-9541(eISSN)
한국발생생물학회 (The Korean Society of Developmental Biology)
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The Impairment of Thyroid Hormones Homeostasis after Short-Term Exposure to Di(2-ethylhexyl)phthalate in Adolescent Male Rats

  • Kim, Sang-Yon (Dept. of Preventive Medicine, College of Medicine, Chung-Ang University) ;
  • Hong, Yeon-Pyo (Dept. of Preventive Medicine, College of Medicine, Chung-Ang University) ;
  • Yang, Yun-Jung (Dept. of Convergence Science, Catholic Kwandong University International St. Mary's Hospital)
  • 투고 : 2021.08.10
  • 심사 : 2021.11.15
  • 발행 : 2021.12.31
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초록

Di(2-ethylhexyl)phthalate (DEHP) could induce metabolic disorders through interfering with thyroid homeostasis. Therefore, we evaluated the effects of short term to environmental relevant doses of DEHP on thyroid hormones. Four week old Sprague-Dawley (SD) rats were treated with vehicle (corn oil), and DEHP 0.75, 7.5, and 150 mg/kg/day. The rats were treated with once daily by oral gavage and were sacrificed with after 1 week. They were measured body weight and relative thyroid weight, serum thyroid hormones and histological changes of thyroid. There was no difference in body weight between the control and DEHP exposed rats. Relative thyroid weight in DEHP 150 mg/kg/day treated group was significantly lower than control. Serum thyroxine levels was decreased in rats exposed to 0.75 and 150 mg/kg/day DEHP. No histological changes were observed in the thyroid of rats administered DEHP compared to control. Exposure to DEHP at environmental relevant levels, even short-term exposure, can cause hypothyroidism in adolescent rats even the exposure period is relative short.

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과제정보

This work has supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2021R1I1A3046386).

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