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Diagnosis of Rare Case of Hepatoblastoma in a Dog

  • Son, Seongin (College of Veterinary Medicine, Kyungpook National University) ;
  • Lee, Seoung-woo (College of Veterinary Medicine, Kyungpook National University) ;
  • Jang, Min (College of Veterinary Medicine, Kyungpook National University) ;
  • Yun, Sungho (College of Veterinary Medicine, Kyungpook National University) ;
  • Kwon, Young-sam (College of Veterinary Medicine, Kyungpook National University) ;
  • Park, Jin-kyu (College of Veterinary Medicine, Kyungpook National University) ;
  • Lee, Kija (College of Veterinary Medicine, Kyungpook National University)
  • Received : 2021.01.02
  • Accepted : 2021.04.08
  • Published : 2021.04.30

Abstract

A 9-year-old, intact female Shih-tzu dog presented with a three-week history of anorexia, lethargy, and weight loss. Abdominal radiography revealed a mass in the right cranial quadrant of the abdomen that was displacing the right kidney caudally. Ultrasonography showed a large, irregular, heterogeneous hepatic mass and a small amount of peritoneal fluid. On computed tomography (CT), a large hypoattenuating mass with heterogeneous contrast enhancement occupied the right lateral lobe, and parts of the right medial and caudate lobes of the liver. There was no evidence of regional lymph node or pulmonary metastasis. Lobectomy of the right medial, right lateral and caudate liver lobes was performed, however, the patient did not recover from surgery. Hepatoblastoma was confirmed by histological examination. Hepatoblastoma is rare in dogs, and this is the first report describing CT imaging of hepatoblastoma in a dog.

Keywords

References

  1. Amendola MA, Blane CE, Amendola BE, Glazer GM. CT findings in hepatoblastoma. J Comput Assist Tomogr 1984; 8: 1105-1109. https://doi.org/10.1097/00004728-198412000-00011
  2. Ano N, Ozaki K, Nomura K, Narama I. Hepatoblastoma in a cat. Vet Pathol 2011; 48: 1020-1023. https://doi.org/10.1177/0300985810390017
  3. Dachman AH, Pakter RL, Ros PR, Fishman EK, Goodman ZD, Lichtenstein JE. Hepatoblastoma: radiologic-pathologic correlation in 50 cases. Radiology 1987; 164: 15-19. https://doi.org/10.1148/radiology.164.1.3035605
  4. Fukushima K, Kenemoto H, Ohno K, Takahashi M, Nakashima K, Fujino Y, Uchida K, Fujiwara R, Nishimura R, Tsujimoto H. CT characteristics of primary hepatic mass lesions in dogs. Vet Radiol Ultrasound 2012; 53: 252-257. https://doi.org/10.1111/j.1740-8261.2011.01917.x
  5. Griebie ER, Dvid FH, Ober CP, Feeney DA, Anderson KL, Wuenschmann A, Jessen CR. Evaluation of canine hepatic masses by use of triphasic computed tomography and B-mode, color flow, power, and pulsed-wave doppler ultrasonography and correlation with histopathologic classification. Am J Vet Res 2017; 78: 1273-1283. https://doi.org/10.2460/ajvr.78.11.1273
  6. Hammer AS, Sikkema DA. Hepatic neoplasia in the dog and cat. Vet Clin North Am Small Anim Pract 1995; 25: 419-435. https://doi.org/10.1016/S0195-5616(95)50035-X
  7. Kutara K, Seki M, Ishikawa C, Sakai M, Kagawa Y, Iida G, Ishigaki K, Teshima K, Edamura K, Nakayama T, Asano K. Triple-phase helical computed tomography in dogs with hepatic masses. Vet Radiol Ultrasound 2014; 55: 7-15. https://doi.org/10.1111/vru.12099
  8. Leela Arporn R, Ohta H, Shimbo G, Hanazono K, Osuga T, Morishita K, Sasaki N, TakiguchIi M. Computed tomographic features for differentiating benign from malignant liver lesions in dogs. J Vet Med Sci 2019; 81: 1697-1704. https://doi.org/10.1292/jvms.19-0278
  9. Li L, Liu W, Wen R, Jin K. Computed tomography imaging and clinical features of congenital hepatoblastoma. Medicine (Baltimore) 2020; 99: e21174. https://doi.org/10.1097/MD.0000000000021174
  10. Magne ML, Withrow SJ. Hepatic neoplasia. Vet Clin North Am Small Anim Pract 1985; 15: 243-256. https://doi.org/10.1016/S0195-5616(85)50014-5
  11. Rougemont AL, Mclin VA, Toso C, Wildhaber BE. Adult hepatoblastoma: learning from children. J Hepatol 2012; 56: 1392-1403. https://doi.org/10.1016/j.jhep.2011.10.028
  12. Shiga A, Shirota K, Shida T, Yamada T, Nomura Y. Hepatoblastoma in a dog. J Vet Med Sci 1997; 59 : 1167-1170. https://doi.org/10.1292/jvms.59.1167
  13. Spector LG, Brich J. The epidemiology of hepatoblastoma. Pediatr Blood Cancer 2012; 59: 776-779. https://doi.org/10.1002/pbc.24215
  14. Stocker JT. Hepatic tumors in children. Clin Liver Dis 2001; 5: 259-281. https://doi.org/10.1016/S1089-3261(05)70163-X
  15. Taniura T, Marukawa K, Yamada K, Hikasa Y, Ito K. Differential diagnosis of hepatic tumor-like lesions in dog by using dynamic CT scanning. Hiroshima J Med Sci 2009; 58: 17-24.