Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Glabridin Liposome Ameliorating UVB-Induced Erythema and Lethery Skin by Suppressing Inflammatory Cytokine Production

  • Zhang, Chijian (Hua An Tang Biotech Group Co., Ltd.) ;
  • Lu, Yongjie (Hua An Tang Biotech Group Co., Ltd.) ;
  • Ai, Yong (Hua An Tang Biotech Group Co., Ltd.) ;
  • Xu, Xian (Hua An Tang Biotech Group Co., Ltd.) ;
  • Zhu, Siyang (Hua An Tang Biotech Group Co., Ltd.) ;
  • Zhang, Bing (Guangdong He Ji Biotech Co., Ltd.) ;
  • Tang, Minghui (Hua An Tang Biotech Group Co., Ltd.) ;
  • Zhang, Lanyue (School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology) ;
  • He, Tinggang (Hua An Tang Biotech Group Co., Ltd.)
  • Received : 2020.11.06
  • Accepted : 2021.02.01
  • Published : 2021.04.28
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Abstract

Glabridin, a compound of the flavonoid, has shown outstanding skin-whitening and anti-aging properties, but its water insolubility limits its wide application. Therefore, glabridin liposome (GL) has been developed to improve its poor bioavailability, while there are few studies to evaluate its amelioration of UVB- induced photoaging. This study is performed to investigate the amelioration of GL against UVB- induced cutaneous photoaging. The prepared GL has a spheroidal morphology with an average diameter of 200 nm. The GL shows lower cytotoxicity than glabridin, but it has a more effective role in inhibition of melanin. Moreover, the application of GL can effectively relieve UV radiation induced erythema and leathery skin, associated with the down-regulated expression of inflammatory cytokines (TNF-α, IL-6 and IL-10). Taken together, these results demonstrate that GL has potentials as topical therapeutic agents against UVB radiation induced skin damage through inhibiting inflammation.

Keywords

References

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