Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제47권2호
  • /
  • Pages.120-127
  • /
  • 2021
  • /
  • 2234-7550(pISSN)
  • /
  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
권호 표지
DOI QR코드

DOI QR Code

Sequential treatment from mandibulectomy to reconstruction on mandibular oral cancer - Case review I: mandibular ramus and angle lesion of primary intraosseous squamous cell carcinoma

  • Lee, Won-Bum (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Hwang, Dae-Seok (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Kim, Uk-Kyu (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University)
  • 투고 : 2020.09.28
  • 심사 : 2020.11.20
  • 발행 : 2021.04.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Primary intraosseous squamous cell carcinoma (PIOSCC) is very rare type of squamous cell carcinoma (SCC) that occurs within the jaw and arises from remnants of odontogenic epithelium with no connection to the oral mucosa. This study reports two cases of PIOSCC of the mandible. Reported in this article are two cases of PIOSCC of the mandible that were treated with resection and reconstruction using a fibular free flap. The first case was a 36-year-old male patient who complained of right mandibular pain. Computed tomography (CT) and panoramic radiograph revealed a large radiolucency in the mandibular ramus area. At first, an odontogenic keratocyst was tentatively diagnosed, and an excision procedure was carried out at another clinic. A final biopsy after cyst enucleation revealed well-differentiated SCC, so we proceeded with segmental mandibulectomy and reconstruction using a fibular free flap. The second case was a 48-year-old male patient with left mandibular pain. CT and panoramic radiograph revealed irregular radiolucency in the mandibular angle area near tooth #38. At first, osteomyelitis was tentatively diagnosed, and a curettage was carried out. A later biopsy revealed well-differentiated SCC, so segmental mandibulectomy and reconstruction with a fibular free flap were secondarily performed. Our two cases have had no recurrence. The facial appearance of both patients is satisfactory, and the neo-mandibular body created using a fibular bone transfer displays adequate bony volume.

키워드

참고문헌

  1. Bodner L, Manor E, Shear M, van der Waal I. Primary intraosseous squamous cell carcinoma arising in an odontogenic cyst: a clinicopathologic analysis of 116 reported cases. J Oral Pathol Med 2011;40:733-8. https://doi.org/10.1111/j.1600-0714.2011.01058.x
  2. Shear M. Primary intra-alveolar epidermoid carcinoma of the jaw. J Pathol 1969;97:645-51. https://doi.org/10.1002/path.1710970409
  3. Chaisuparat R, Coletti D, Kolokythas A, Ord RA, Nikitakis NG. Primary intraosseous odontogenic carcinoma arising in an odontogenic cyst or de novo: a clinicopathologic study of six new cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:194-200. https://doi.org/10.1016/j.tripleo.2005.03.037
  4. McGowan RH. Primary intra-alveolar carcinoma. A difficult diagnosis. Br J Oral Surg 1980;18:259-65. https://doi.org/10.1016/0007-117x(80)90071-2
  5. Thomas G, Pandey M, Mathew A, Abraham EK, Francis A, Somanathan T, et al. Primary intraosseous carcinoma of the jaw: pooled analysis of world literature and report of two new cases. Int J Oral Maxillofac Surg 2001;30:349-55. https://doi.org/10.1054/ijom.2001.0069
  6. Huang JW, Luo HY, Li Q, Li TJ. Primary intraosseous squamous cell carcinoma of the jaws. Clinicopathologic presentation and prognostic factors. Arch Pathol Lab Med 2009;133:1834-40. https://doi.org/10.1043/1543-2165-133.11.1834
  7. Williams MD. Update from the 4th edition of the World Health Organization Classification of Head and Neck Tumours: mucosal melanomas. Head Neck Pathol 2017;11:110-7. https://doi.org/10.1007/s12105-017-0789-y
  8. Sharma M, Wakure A, Thankappan K, Mathew J, Jairaj D, Dudipala RR, et al. Anatomic basis for an algorithmic approach for free fibula flap donor side selection in composite oromandibular defects. Indian J Plast Surg 2015;48:43-7. https://doi.org/10.4103/0970-0358.155268
  9. Thakur A, Tupkari JV, Joy T, Gogri AA. Primary intraosseous squamous cell carcinoma - a rare odontogenic malignancy. J Oral Maxillofac Pathol 2017;21:320. https://doi.org/10.4103/jomfp.JOMFP_25_16
  10. Suei Y, Taguchi A, Tanimoto K. Recommendation of modified classification for odontogenic carcinomas. Med Hypotheses 2004;62:382-6. https://doi.org/10.1016/j.mehy.2003.11.010
  11. Elzay RP. Primary intraosseous carcinoma of the jaws. Review and update of odontogenic carcinomas. Oral Surg Oral Med Oral Pathol 1982;54:299-303. https://doi.org/10.1016/0030-4220(82)90099-8
  12. Dai YL, King AD. State of the art MRI in head and neck cancer. Clin Radiol 2018;73:45-59. https://doi.org/10.1016/j.crad.2017.05.020
  13. Wenguang X, Hao S, Xiaofeng Q, Zhiyong W, Yufeng W, Qingang H, et al. Prognostic factors of primary intraosseous squamous cell carcinoma (PIOSCC): a retrospective review. PLoS One 2016;11:e0153646. https://doi.org/10.1371/journal.pone.0153646
  14. de Morais EF, Carlan LM, de Farias Morais HG, Pinheiro JC, Martins HDD, Barboza CAG, et al. Primary intraosseous squamous cell carcinoma involving the jaw bones: a systematic review and update. Head Neck Pathol 2020. https://doi.org/10.1007/s12105-020-01234-z [Epub ahead of print]
  15. Dimitrakopoulos I, Psomaderis K, Asimaki A, Papaemanouel S, Karakasis D. Primary de novo intraosseous carcinoma: report of two cases. J Oral Maxillofac Surg 2005;63:1227-30. https://doi.org/10.1016/j.joms.2005.04.009