대한융합한의학회지 (Journal of Convergence Korean Medicine)

대한융합한의학회 (Academy of Convergence Korean Medicine)
권호 표지

천연물 외용제를 적용한 아토피피부염 증례 및 임상 연구 고찰

A Study on Cases and Clinical Trials Applying Topical Agents Including Natural Products for Atopic Dermatitis Treatment

  • 서광일 (경희대학교 한의과대학원 임상한의학과 (안이비인후피부과 전공)) ;
  • 김규석 (경희대학교 한의과대학 안이비인후피부과 교실)
  • Gwang-Yeel Seo (Department of Clinical Korean Medicine, Graduate School of Korean Medicine, Kyung Hee University) ;
  • Kyuseok Kim (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University)
  • 투고 : 2021.07.05
  • 심사 : 2021.12.26
  • 발행 : 2021.12.31
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초록

Objectives: To investigate the characteristics of topical agents including natural products using for atopic dermatitis treatment via a review on the cases and clinical trials. Methods: Through a search on Pubmed, EMBASE, Cochrane library, DBPIA, NDSL, and OASIS, we selected papers that applied natural products externally for atopic dermatitis and analyzed them. Results: Finally, Seventeen papers were selected. As the primary outcome, changes in the SCORAD and EASI, were the most used. The most frequent type of external formulation was cream. In terms of the frequency of use, it was used at least twice a day in all studies. When evaluated based on SCORAD, EASI, SH and TEWL, the improvement effect on atopic dermatitis was highest when the ointment formulation and the moisturizer formulation were used. A few side effects of topical agents including natural products were observed, but most were mild symptoms and no serious side effects occurred. Conclusion: This study is meaningful in that it has drawn a significant trend for studies that have been published in the last 5 years that contain a single intervention for topical agents including natural products, and that it presents the direction and evidence for the application of external therapy to increase the therapeutic effect of atopic dermatitis.

키워드

참고문헌

  1. Mayba JN, Gooderham MJ. Review of atopic dermatitis and topical therapies. J Cutan Med Surg. 2017;21(3):227-236. https://doi.org/10.1177/1203475416685077
  2. Kim JW, LEE GH. Atopic Dermatitis. KOONJA. 2017:22, 75, 76.
  3. Kim MS, Seo YW, Park JY, Kim CH, Lee ES, Kim EK, et al. Predictive Factors for Medication Adherence in a Geriatric Assessment Program in Korea. J Korean Soc Heal Pharm. 2018;35(4): 418-429.
  4. Park KS, Gam S, Kim HS, Lee JK, Hwang JB. Therapeutic compliance and its related factors in pediatrics patients. Korean J Pediatr. 2008;51(6):584-596.
  5. Kim HS, Cho SH. Treatment for atopic dermatitis. J Korean Med Assoc. 2014;57(3):205-207. https://doi.org/10.5124/jkma.2014.57.3.205
  6. Hon KL, Kung JSC, Ng WGG, Leung TF. Emollient treatment of atopic dermatitis: latest evidence and clinical considerations. Drugs Context. 2018;7:212530.
  7. Thandar Y, Gray A, Botha J, Mosam A. Topical herbal medicines for atopic eczema: a systematic review of randomized controlled trials. Br J Dermatol. 2017;176(2):330-343. https://doi.org/10.1111/bjd.14840
  8. Mainzer C, Le Guillou M, Vyumvuhore R, Chadoutaud B, Bordes S, Closs B. Clinical efficacy of oligofructans from ophiopogon japonicus in reducing atopic dermatitis flare-ups in caucasian patients. Acta Derm Venereol. 2019 ;99(10):858-864.
  9. Mori K, Seki T, Kaizu K, Takagi Y, Miyaki M, Ishizaki C, et al. Efficacy of a moisturizer containing a pseudo-ceramide and a eucalyptus extract for Japanese patients with mild atopic dermatitis in the summer. J Cosmet Dermatol. 2019;18(3):850-856. https://doi.org/10.1111/jocd.12735
  10. Somjorn P, Kamanamool N, Kanokrungsee S, Rojhirunsakool S, Udompataikul M. A cream containing linoleic acid, 5% dexpanthenol and ceramide in the treatment of atopic dermatitis. Asian Pacific J Allergy Immunol. 2021 ; 10.12932/AP-221220-1021.
  11. Hoffmann J, Wolfle U, Schempp CM, Casetti F. Tannins from Potentilla officinalis display antiinflammatory effects in the UV erythema test and on atopic skin. JDDG - J Ger Soc Dermatology. 2016;14(9):917-922.
  12. Yen CY, Hsieh CL. Therapeutic Effect of Tzu-Yun Ointment on Patients with Atopic Dermatitis: A Preliminary, Randomized, Controlled, Open-Label Study. J Altern Complement Med. 2016;22(3):237-243.
  13. Abbasi S, Kamalinejad M, Babaie D, Shams SM, Sadr Z, Gheysari M, et al. A new topical treatment of atopic dermatitis in pediatric patients based on Ficus carica L. (Fig) : A randomized, placebo-controlled clinical trial. Complement Ther Med. 2017;35:85-91. https://doi.org/10.1016/j.ctim.2017.10.003
  14. Sgouros D, Katoulis A, Rigopoulos D. Novel topical agent containing superoxide dismutase 100 000 IU and 4% of plant extracts as a mono-therapy for atopic dermatitis. J Cosmet Dermatol. 2018;17(6):1069-1072. https://doi.org/10.1111/jocd.12462
  15. Choi Y, Jo YCSSH, Lee E. Retrospective Study about the Effectiveness of Topical Preparations Containing 12 Herbal Extracts on Atopic Dermatitis Patients. J Korean Medicine Ophthalmology and Otolaryngology and Dermatology. 2018;31(2):104-112.
  16. Ahn JH, Yun Y, Kim MH, Ko SG, Kim KS, Choi I. Exploring the efficacy and safety of topical Jaungo application in patients with atopic dermatitis: A pilot randomized, double-blind, placebo-controlled study. Complement Ther Med. 2018;40:22-28. https://doi.org/10.1016/j.ctim.2018.07.007
  17. Park HS, Kim YM, Kim HT. A Clinical Study for the Efficacy and Safety of Functional Cosmetics Containing Humulus japonicus Extract in Patients with Dry Skin due to Mild Atopic Dermatitis. J Korean Orient Ophthalmol. 2019; 32(3):24-58.
  18. Seiwerth J, Tasiopoulou G, Hoffmann J, Wolfle U, Schwabe K, Quirin KW, et al. Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract. Planta Med. 2019;85(7):608-614. https://doi.org/10.1055/a-0835-6806
  19. Park HS, Kim TJ, Park SY, Kim HT. A Clinical Study for the Efficacy and Safety of Functional Cosmetics Containing peptide Scolopendrasin-I isolated from the Scolopendra subspinipes mutilans in Patients with Dry Skin due to Mild Atopic Dermatitis. J Korean Orient Ophthalmol. 2019;32(2):23-36.
  20. Hon KL, Kung JS, Ng WGG, Leung TF. Testing an Ectoin Containing Emollient for Atopic Dermatitis. Curr Pediatr Rev. 2019;15(3): 191-195.
  21. Lin YK, Chang SH, Yang CY, See LC, Lee BH, Shih IH. Efficacy and safety of indigo naturalis ointment in Treating Atopic Dermatitis: A randomized clinical trial: Indigo naturalis in Treating Atopic Dermatitis. J Ethnopharmacol. 2020;250:112477.
  22. Waranaree Winayanuwattikun SV, Tuchinda P, Kanokvalai Kulthanan, Nuntida Prasertworonun, Phongphimon Dasri, Kwanjeera Wanichthanarak PA. A double-blinded, randomized, split-side, vehicle-controlled study of the efficacy of cleanser containing Acanthus ebracteatus Vahl, Suregada multiflora, and Acacia concinna in patients with atopic dermatitis: A pilot study. Asian Pacific J Allergy Immunol. 2020;10.12932/AP-050519-0554.
  23. Naseri V, Chavoshzadeh Z, Mizani A, Daneshfard B, Ghaffari F, Abbas-Mohammadi M, et al. Effect of topical marshmallow (Althaea officinalis) on atopic dermatitis in children: A pilot double-blind active-controlled clinical trial of an in-silico-analyzed phytomedicine. Phyther Res. 2021; 35(3):1389-1398.
  24. Ng WGG, Hon KL, Kung JSC, Cheng NS, Koh MJA, Huang H, et al. Effect of pine-tar bath on disease severity in moderate-to-severe childhood eczema: an investigator-blinded, crossover, randomized clinical trial. Journal of Dermatological Treatment. 2022;33(1):157-65.
  25. Wollenberg A, Folster-Holst R, Saint Aroman M, Sampogna F, Vestergaard C. Effects of a protein-free oat plantlet extract on microinflammation and skin barrier function in atopic dermatitis patients. J Eur Acad Dermatology Venereol. 2018;32 Suppl 1:1-15.
  26. Eichenfield LF, Tom WL, Berger TG, Krol A, Paller AS, Schwarzenberger K, et al. Guidelines of care for the management of atopic dermatitis: Section 2. Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol. 2014;71(1) :116-132. https://doi.org/10.1016/j.jaad.2014.03.023