Journal of Convergence Korean Medicine (대한융합한의학회지)

Academy of Convergence Korean Medicine (대한융합한의학회)
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Fabrication of an ultra-fine ginsenoside particle atomizer for drug delivery through respiratory tract

호흡기를 통한 약액 전달을 위한 진세노사이드 초미세입자 분무장치 제작

  • Byung Chul Lee (Brain Science Institute, Korea Institute of Science and Technology) ;
  • Jin Soo Park (Brain Science Institute, Korea Institute of Science and Technology) ;
  • Woong Mo Yang (Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University)
  • 이병철 (한국과학기술연구원 뇌과학연구소) ;
  • 박진수 (한국과학기술연구원 뇌과학연구소) ;
  • 양웅모 (경희대학교 한의과대학 융합한의과학교실)
  • Received : 2021.10.11
  • Accepted : 2021.12.26
  • Published : 2021.12.31
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Abstract

Objectives: The purpose of this study is to fabricate an ultra-fine ginsenoside particle atomizer that can provide a new treatment method by delivering ginsenoside components that have a therapeutic effect on respiratory diseases directly to the lungs. Methods: We fabricated the AAO vibrating mesh by using the micromachining process. The starting substrate of an AAO wafer has a 350nm pore diameter with 50㎛ thickness. A photomask having several 5㎛ opening holes with a 100㎛ pitch was used to separate each nanopore nozzle. The photoresist structure was optimized to pattern the nozzle area during the lift-off process precisely. The commercial vibrating mesh was removed from OMRON's NE-U100 product, and the fabricated AAO vibrating mesh was installed. A diluted sample of 20mL with 30% red ginseng concentrate was prepared to atomize from the device. Results: As a result of liquid chromatography analysis before spraying the ginsenoside solution, ginsenoside components such as 20S-Rg3, 20R-Rg3, and Rg5 were detected. After spraying through the AAO vibrating mesh, ginsenosides of the same component could be detected. Conclusion: A nutrient solution containing ginsenosides was successfully sprayed through the AAO vibrating mesh with 350 nm selective pores. In particular, during the atomizing experiment of ginsenoside drug solution having excellent efficacy in respiratory diseases, it was confirmed that atomizing through the AAO vibrating mesh while maintaining most of the active ingredients was carried out.

Keywords

Acknowledgement

본 연구는 과학기술정보통신부의 재원으로 한국연구재단 바이오·의료기술개발사업의 지원을 받아 수행된 연구입니다(NRF-2018M3A9G5075749). 본 연구는 정부 (과학기술정보통신부, 산업통상자원부, 보건복지부, 식품의약품안전처)의 재원으로 범부처전주기 의료기기연구개발사업단의 지원을 받아 수행된 연구입니다(KMDF_PR_20200901_0064). AAO 진동 메쉬의 제작은 한국과학기술연구원 마이크로나노팹에서 진행이 되었으며, 각 SEM 사진과 HPLC의 데이터는 한국과학기술연구원 특성분석센터에서 획득하였다. 본 연구를 위해 다양한 의료용 흡입기 정보 및 상용화 정보를 제공해준 크루셜텍(주)에도 감사의 인사를 드립니다.

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