Journal of Gastric Cancer

  • 제21권1호
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  • Pages.103-109
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  • 2021
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  • 2093-582X(pISSN)
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  • 2093-5641(eISSN)
대한위암학회 (The Korean Gastric Cancer Association)
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Long-term Observation of Gastric Adenocarcinoma of Fundic Gland Mucosa Type before and after Helicobacter pylori Eradication: a Case Report

  • Takahashi, Keitaro (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Ueno, Nobuhiro (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Sasaki, Takahiro (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Kobayashi, Yu (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Sugiyama, Yuya (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Murakami, Yuki (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Kunogi, Takehito (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Ando, Katsuyoshi (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Kashima, Shin (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Moriichi, Kentaro (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Tanabe, Hiroki (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Kamikokura, Yuki (Department of Diagnostic Pathology, Asahikawa Medical University Hospital) ;
  • Yuzawa, Sayaka (Department of Diagnostic Pathology, Asahikawa Medical University Hospital) ;
  • Tanino, Mishie (Department of Diagnostic Pathology, Asahikawa Medical University Hospital) ;
  • Okumura, Toshikatsu (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Fujiya, Mikihiro (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University)
  • 투고 : 2021.02.22
  • 심사 : 2021.03.22
  • 발행 : 2021.03.31
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초록

Gastric adenocarcinoma of the fundic gland mucosa type (GA-FGM) was proposed as a new variant of gastric adenocarcinoma of the fundic gland type (GA-FG). However, at present, the influence of Helicobacter pylori and the speed of progression and degree of malignancy in GA-FGM remain unclear. Herein, we report the first case of intramucosal GA-FGM that was endoscopically observed before and after H. pylori eradication over 15 years. The lesion showed the same tumor size with no submucosal invasion and a low MIB-1 labeling index 15 years after its detection using endoscopy. The endoscopic morphology changed from 0-IIa before H. pylori eradication to 0-IIa+IIc and then 0-I after H. pylori eradication. These findings suggest that the unaltered tumor size reflects low-grade malignancy and slow growth, and that the endoscopic morphology is influenced by H. pylori eradication.

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참고문헌

  1. Ueyama H, Matsumoto K, Nagahara A, Hayashi T, Yao T, Watanabe S. Gastric adenocarcinoma of the fundic gland type (chief cell predominant type). Endoscopy 2014;46:153-157. https://doi.org/10.1055/s-0033-1359042
  2. Chiba T, Kato K, Masuda T, Ohara S, Iwama N, Shimada T, et al. Clinicopathological features of gastric adenocarcinoma of the fundic gland (chief cell predominant type) by retrospective and prospective analyses of endoscopic findings. Dig Endosc 2016;28:722-730. https://doi.org/10.1111/den.12676
  3. Li C, Wu X, Yang S, Yang X, Yao J, Zheng H. Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection. Diagn Pathol 2020;15:131. https://doi.org/10.1186/s13000-020-01047-2
  4. Miyazawa M, Matsuda M, Yano M, Hara Y, Arihara F, Horita Y, et al. Gastric adenocarcinoma of the fundic gland (chief cell-predominant type): a review of endoscopic and clinicopathological features. World J Gastroenterol 2016;22:10523-10531. https://doi.org/10.3748/wjg.v22.i48.10523
  5. Singhi AD, Lazenby AJ, Montgomery EA. Gastric adenocarcinoma with chief cell differentiation: a proposal for reclassification as oxyntic gland polyp/adenoma. Am J Surg Pathol 2012;36:1030-1035. https://doi.org/10.1097/PAS.0b013e31825033e7
  6. Tanabe H, Iwashita A, Ikeda K, Ota A, Yao K. Histopathological characteristics of gastric adenocarcinoma of fundic gland type. Stomach Intestine 2015;50:1469-1479.
  7. Fujiwara S, Yao K, Imamura K, Tanabe H, Yasaka T, Ishihara H, et al. M-NBI findings of gastric adenocarcinoma of fundic gland type and adenocarcinoma with differentiation towards the fundic mucosa. Stomach Intestine 2015;50:1548-1558.
  8. Takahashi K, Fujiya M, Ichihara S, Moriichi K, Okumura T. Inverted gastric adenocarcinoma of fundic gland mucosa type colliding with well differentiated adenocarcinoma: a case report. Medicine (Baltimore) 2017;96:e7080. https://doi.org/10.1097/MD.0000000000007080
  9. Yaita H, Kurahara K, Oshiro Y, Kameda M, Kuno N, Yao T, et al. Gastric adenocarcinoma of the fundic mucosa type with type A gastritis, report of a case. Stomach Intestine 2017;52:1366-1374.
  10. Ikeda A, Ueyama H, Yatagai S, Akazawa Y, Komori H, Mastumoto K, et al. A case of reddish/raised type fundic gland mucosal type gastric cancer. Clin Gastroenterol 2019;34:563-568.
  11. Ishibashi H, Nimura S, Tanabe T, Kayashima Y, Matsumoto K, Yamaguchi M, et al. A case of gastric adenocarcinoma of fundic gland mucosa type arising from Helicobacter pylori negative mucosa. Med Bull Fukuoka Univ 2020;47:87-92.
  12. Kojima K, Uchita K. A case of fundic mucosal gastric cancer with white-toned flat ridge. Clin Gastroenterol 2020;35:1395-1399.
  13. Ogasawara N, Toba T, Iizuka T, Hoteiya S, Inoshita N, Kaise M. A case of gastric adenocarcinoma of the fundic gland mucosa type treated by endoscopic submucosal dissection after eight-year observation. Prog dig Endosc 2018;93:87-95. https://doi.org/10.11641/pde.93.1_87
  14. Sato Y, Sato T, Matsushima J, Fujii A, Ono Y, Suda T, et al. Histopathologic change of a case of gastric oxyntic neoplasm (gastric adenocarcinoma of fundic gland mucosa type) through 5 years with concurrent other oxyntic gland lesions. Int J Surg Pathol 2020;1066896920962574.
  15. Nakagawa M, Sakai Y, Kiriyama Y, Tahara T, Horiguchi N, Okabe A, et al. Eradication of Helicobacter pylori induces immediate regressive changes in early gastric adenocarcinomas. Pathobiology 2019;86:135-144. https://doi.org/10.1159/000496692
  16. Ito M, Tanaka S, Takata S, Oka S, Imagawa S, Ueda H, et al. Morphological changes in human gastric tumours after eradication therapy of Helicobacter pylori in a short-term follow-up. Aliment Pharmacol Ther 2005;21:559-566. https://doi.org/10.1111/j.1365-2036.2005.02360.x
  17. Ishibashi F, Fukushima K, Ito T, Kobayashi K, Tanaka R, Onizuka R. Influence of Helicobacter pylori infection on endoscopic findings of gastric adenocarcinoma of the fundic gland type. J Gastric Cancer 2019;19:225-233. https://doi.org/10.5230/jgc.2019.19.e21
  18. Kumei S, Noguchi H, Watanabe T, Kume K, Yoshikawa I, Nakayama T, et al. Gastric adenocarcinoma of the fundic mucosa type with a peculiar appearance, report of a case. Stomach Intestine 2018;53:893-903.
  19. Uchida A, Ozawa M, Ueda Y, Murai Y, Nishimura Y, Ishimatsu H, et al. Gastric adenocarcinoma of fundic gland mucosa type localized in the submucosa: a case report. Medicine (Baltimore) 2018;97:e12341. https://doi.org/10.1097/md.0000000000012341
  20. Miyajima N, Okawara A, Kamoshida T, Hirai S, Yanaka A. Case reports of fundic gland- and fundic gland mucosa-type adenocarcinoma at our hospital. Prog dig Endosc 2019;95:38-40. https://doi.org/10.11641/pde.95.1_38
  21. Imamura K, Yao K, Tanabe H, Nimura S, Kanemitsu T, Miyaoka M, et al. Characteristic endoscopic findings and clinical pathology associated with gastric adenocarcinoma of fundic gland mucosa type in patients without H. pylori infection. Stomach Intest 2020;55:1022-1035.
  22. Ueo T, Yonemasu H, Ishida T. Gastric adenocarcinoma of fundic gland type with unusual behavior. Dig Endosc 2014;26:293-294.
  23. Okumura Y, Takamatsu M, Ohashi M, Yamamoto Y, Yamamoto N, Kawachi H, et al. Gastric adenocarcinoma of fundic gland type with aggressive transformation and lymph node metastasis: a case report. J Gastric Cancer 2018;18:409-416. https://doi.org/10.5230/jgc.2018.18.e22