동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제32권1호
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  • Pages.25-37
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  • 2021
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  • 1226-6396(pISSN)
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  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
권호 표지
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한약처방 JSB가 구금스트레스로 우울증을 유발한 생쥐의 행동과 생체지표에 미치는 영향

Effects of JSB, a Korean Medicine, on Behaviors and Biological Factors in a Mouse Model of Depression Induced by Restraint Stress

  • 신윤민 (대전대학교 한의과대학 분자의학실험실) ;
  • 임형택 (자하연한의원) ;
  • 황은영 (자하연한의원) ;
  • 김가나 (자하연한의원) ;
  • 이원길 (대전대학교 한의과대학 분자의학실험실) ;
  • 김연경 (대전대학교 한의과대학 분자의학실험실) ;
  • 장희진 (대전대학교 한의과대학 분자의학실험실) ;
  • 최정준 (대전대학교 한의과대학 분자의학실험실)
  • Shin, Younmin (Laboratory of Molecular Medicine, College of Korean Medicine, Daejeon University) ;
  • Lim, Hyung Taeck (Jahayun Korean Medical Clinic) ;
  • Hwang, Eun-Young (Jahayun Korean Medical Clinic) ;
  • Kim, Ka-Na (Jahayun Korean Medical Clinic) ;
  • Lee, Won Kil (Laboratory of Molecular Medicine, College of Korean Medicine, Daejeon University) ;
  • Kim, Yeongyeong (Laboratory of Molecular Medicine, College of Korean Medicine, Daejeon University) ;
  • Jang, Heejin (Laboratory of Molecular Medicine, College of Korean Medicine, Daejeon University) ;
  • Choi, Jeong June (Laboratory of Molecular Medicine, College of Korean Medicine, Daejeon University)
  • 투고 : 2020.10.25
  • 심사 : 2021.03.25
  • 발행 : 2021.03.30
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초록

Objectives: Depression is a mood disorder showing low energy, loss of interest, anhedonia, and anxiety. It affects a patients' daily life. This disease is considered a social problem because the patient may commit suicide in extreme cases. JSB is composed of 12 Korean medicinal herbs. It has been prescribed to patients with depression. The objective of this study is to investigate anti-depressive effects of JSB on restraint stress-induced depression in a mouse model. Methods: Depression was induced by restraint stress. Mice were orally administered JSB at 10, 20, or 40 mg/kg for 14 days. Forced swimming test (FST) and open field test (OFT) were performed. Brain-derived neurotrophic factor (BDNF) mRNA level was measured by real time-PCR. Plasma levels of corticosterone and serotonin were measured by ELISA. Blood levels of AST and ALS were measured using a biochemical analyzer. Results: JSB treatment significantly reduced the immobility time in FST. BDNF mRNA level was increased by JSB treatment in the hippocampi of mice. Although the expression of TNF-α was also increased by JSB, such increase was not statistically significant. The increase of corticosterone level in plasma induced by restraint stress was significantly down-regulated by JSB. JSB reduced blood level of AST, but not ALT. Conclusions: JSB has a potential to manage depression, setting a foundation for clinical application of Korean medicine with safety.

키워드

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