과제정보
This study was supported by the Research Institute for Veterinary Science, Seoul National University. In addition, this research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (550-20190038). These funds contributed to the collection, analysis, and interpretation of data in this study.
참고문헌
- Teske E. Canine malignant lymphoma: a review and comparison with human non-Hodgkin's lymphoma. Vet Q. 1994;16(4):209-219. https://doi.org/10.1080/01652176.1994.9694451
- Uozurmi K, Nakaichi M, Yamamoto Y, Une S, Taura Y. Development of multidrug resistance in a canine lymphoma cell line. Res Vet Sci. 2005;78(3):217-224. https://doi.org/10.1016/j.rvsc.2004.09.012
- Flory AB, Rassnick KM, Erb HN, Garrett LD, Northrup NC, Selting KA, et al. Evaluation of factors associated with second remission in dogs with lymphoma undergoing retreatment with a cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy protocol: 95 cases (2000-2007). J Am Vet Med Assoc. 2011;238(4):501-506. https://doi.org/10.2460/javma.238.4.501
- Gavazza A, Lubas G, Valori E, Gugliucci B. Retrospective survey of malignant lymphoma cases in the dog: clinical, therapeutical and prognostic features. Vet Res Commun. 2008;32 Suppl 1:S291-S293.
- Niu B, Scott AD, Sengupta S, Bailey MH, Batra P, Ning J, et al. Protein-structure-guided discovery of functional mutations across 19 cancer types. Nat Genet. 2016;48(8):827-837. https://doi.org/10.1038/ng.3586
- Ahn DH, Ciombor KK, Mikhail S, Bekaii-Saab T. Genomic diversity of colorectal cancer: changing landscape and emerging targets. World J Gastroenterol. 2016;22(25):5668-5677. https://doi.org/10.3748/wjg.v22.i25.5668
- Breslin S, O'Driscoll L. Three-dimensional cell culture: the missing link in drug discovery. Drug Discov Today. 2013;18(5-6):240-249. https://doi.org/10.1016/j.drudis.2012.10.003
- Xu X, Farach-Carson MC, Jia X. Three-dimensional in vitro tumor models for cancer research and drug evaluation. Biotechnol Adv. 2014;32(7):1256-1268. https://doi.org/10.1016/j.biotechadv.2014.07.009
- Menshykau D. Emerging technologies for prediction of drug candidate efficacy in the preclinical pipeline. Drug Discov Today. 2017;22(11):1598-1603. https://doi.org/10.1016/j.drudis.2017.04.019
- Benien P, Swami A. 3D tumor models: history, advances and future perspectives. Future Oncol. 2014;10(7):1311-1327. https://doi.org/10.2217/fon.13.274
- Nath S, Devi GR. Three-dimensional culture systems in cancer research: focus on tumor spheroid model. Pharmacol Ther. 2016;163:94-108. https://doi.org/10.1016/j.pharmthera.2016.03.013
- Shoval H, Karsch-Bluman A, Brill-Karniely Y, Stern T, Zamir G, Hubert A, et al. Tumor cells and their crosstalk with endothelial cells in 3D spheroids. Sci Rep. 2017;7(1):10428. https://doi.org/10.1038/s41598-017-10699-y
- Langhans SA. Three-dimensional in vitro cell culture models in drug discovery and drug repositioning. Front Pharmacol. 2018;9:6. https://doi.org/10.3389/fphar.2018.00006
- DelNero P, Lane M, Verbridge SS, Kwee B, Kermani P, Hempstead B, et al. 3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways. Biomaterials. 2015;55:110-118. https://doi.org/10.1016/j.biomaterials.2015.03.035
- Li J, Wu X, Gong J, Yang J, Leng J, Chen Q, et al. Vascular endothelial growth factor induces multidrug resistance-associated protein 1 overexpression through phosphatidylinositol-3-kinase/protein kinase B signaling pathway and transcription factor specificity protein 1 in BGC823 cell line. Acta Biochim Biophys Sin (Shanghai). 2013;45(8):656-663. https://doi.org/10.1093/abbs/gmt062
- Di C, Zhao Y. Multiple drug resistance due to resistance to stem cells and stem cell treatment progress in cancer (Review). Exp Ther Med. 2015;9(2):289-293. https://doi.org/10.3892/etm.2014.2141
- Correia AL, Bissell MJ. The tumor microenvironment is a dominant force in multidrug resistance. Drug Resist Updat. 2012;15(1-2):39-49. https://doi.org/10.1016/j.drup.2012.01.006
- Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. 2012;21(3):309-322. https://doi.org/10.1016/j.ccr.2012.02.022
- Khodarev NN, Yu J, Labay E, Darga T, Brown CK, Mauceri HJ, et al. Tumour-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells. J Cell Sci. 2003;116(Pt 6):1013-1022. https://doi.org/10.1242/jcs.00281
- von Andrian UH, Mempel TR. Homing and cellular traffic in lymph nodes. Nat Rev Immunol. 2003;3(11):867-878. https://doi.org/10.1038/nri1222
- Nakaichi M, Taura Y, Kanki M, Mamba K, Momoi Y, Tsujimoto H, et al. Establishment and characterization of a new canine B-cell leukemia cell line. J Vet Med Sci. 1996;58(5):469-471. https://doi.org/10.1292/jvms.58.469
- Gambara G, Gaebler M, Keilholz U, Regenbrecht CR, Silvestri A. From chemotherapy to combined targeted therapeutics: in vitro and in vivo models to decipher intra-tumor heterogeneity. Front Pharmacol. 2018;9:77. https://doi.org/10.3389/fphar.2018.00077
- Fang X, Sittadjody S, Gyabaah K, Opara EC, Balaji KC. Novel 3D co-culture model for epithelial-stromal cells interaction in prostate cancer. PLoS One. 2013;8(9):e75187. https://doi.org/10.1371/journal.pone.0075187
- Bahrami A, Hassanian SM, Khazaei M, Hasanzadeh M, Shahidsales S, Maftouh M, et al. The therapeutic potential of targeting tumor microenvironment in breast cancer: rational strategies and recent progress. J Cell Biochem. 2018;119(1):111-122. https://doi.org/10.1002/jcb.26183
- Nunes AS, Barros AS, Costa EC, Moreira AF, Correia IJ. 3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs. Biotechnol Bioeng. 2019;116(1):206-226. https://doi.org/10.1002/bit.26845
- Margolin DA, Silinsky J, Grimes C, Spencer N, Aycock M, Green H, et al. Lymph node stromal cells enhance drug-resistant colon cancer cell tumor formation through SDF-1α/CXCR4 paracrine signaling. Neoplasia. 2011;13(9):874-886. https://doi.org/10.1593/neo.11324
- Severino P, Palomino DT, Alvarenga H, Almeida CB, Pasqualim DC, Cury A, et al. Human lymph node-derived fibroblastic and double-negative reticular cells alter their chemokines and cytokines expression profile following inflammatory stimuli. Front Immunol. 2017;8:141.
- Parums DV, Cordell JL, Micklem K, Heryet AR, Gatter KC, Mason DY. JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. J Clin Pathol. 1990;43(9):752-757. https://doi.org/10.1136/jcp.43.9.752
- Fiedler U, Christian S, Koidl S, Kerjaschki D, Emmett MS, Bates DO, et al. The sialomucin CD34 is a marker of lymphatic endothelial cells in human tumors. Am J Pathol. 2006;168(3):1045-1053. https://doi.org/10.2353/ajpath.2006.050554
- Henke E, Nandigama R, Ergun S. Extracellular matrix in the tumor microenvironment and its impact on cancer therapy. Front Mol Biosci. 2020;6:160. https://doi.org/10.3389/fmolb.2019.00160
- Rohwer N, Cramer T. Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways. Drug Resist Updat. 2011;14(3):191-201. https://doi.org/10.1016/j.drup.2011.03.001
- Nelson CM, Chen CS. VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. J Cell Sci. 2003;116(Pt 17):3571-3581. https://doi.org/10.1242/jcs.00680
- Zandvliet M, Teske E, Schrickx JA. Multi-drug resistance in a canine lymphoid cell line due to increased P-glycoprotein expression, a potential model for drug-resistant canine lymphoma. Toxicol In Vitro. 2014;28(8):1498-1506. https://doi.org/10.1016/j.tiv.2014.06.004
- Simon D, Moreno SN, Hirschberger J, Moritz A, Kohn B, Neumann S, et al. Efficacy of a continuous, multiagent chemotherapeutic protocol versus a short-term single-agent protocol in dogs with lymphoma. J Am Vet Med Assoc. 2008;232(6):879-885. https://doi.org/10.2460/javma.232.6.879
- Pedersen SF, Hoffmann EK, Novak I. Cell volume regulation in epithelial physiology and cancer. Front Physiol. 2013;4:233. https://doi.org/10.3389/fphys.2013.00233
- Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013;19(11):1423-1437. https://doi.org/10.1038/nm.3394
- da Cunha BR, Domingos C, Stefanini AC, Henrique T, Polachini GM, Castelo-Branco P, et al. Cellular interactions in the tumor microenvironment: the role of secretome. J Cancer. 2019;10(19):4574-4587. https://doi.org/10.7150/jca.21780
- Yuan Y, Jiang YC, Sun CK, Chen QM. Role of the tumor microenvironment in tumor progression and the clinical applications (Review). Oncol Rep. 2016;35(5):2499-2515. https://doi.org/10.3892/or.2016.4660
- Deying W, Feng G, Shumei L, Hui Z, Ming L, Hongqing W. CAF-derived HGF promotes cell proliferation and drug resistance by up-regulating the c-Met/PI3K/Akt and GRP78 signalling in ovarian cancer cells. Biosci Rep. 2017;37(2):37.
- Katsuno Y, Meyer DS, Zhang Z, Shokat KM, Akhurst RJ, Miyazono K, et al. Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition. Sci Signal. 2019;12(570):eaau8544. https://doi.org/10.1126/scisignal.aau8544
- Kim SM, Li Q, An JH, Chae HK, Yang JI, Ryu MO, et al. Enhanced angiogenic activity of dimethyloxalylglycine-treated canine adipose tissue-derived mesenchymal stem cells. J Vet Med Sci. 2019;81(11):1663-1670. https://doi.org/10.1292/jvms.19-0337
- Zandvliet M, Teske E, Schrickx JA, Mol JA. A longitudinal study of ABC transporter expression in canine multicentric lymphoma. Vet J. 2015;205(2):263-271. https://doi.org/10.1016/j.tvjl.2014.11.002