Journal of Veterinary Science

The Korean Society of Veterinary Science (대한수의학회)
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Cerebrospinal fluid flow in normal beagle dogs analyzed using magnetic resonance imaging

  • Cho, Hyunju (Research Institute of Veterinary Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Yejin (Research Institute of Veterinary Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Hong, Saebyel (Research Institute of Veterinary Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Choi, Hojung (Research Institute of Veterinary Medicine, College of Veterinary Medicine, Chungnam National University)
  • Received : 2020.09.08
  • Accepted : 2020.11.05
  • Published : 2021.01.31
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Abstract

Background: Diseases related to cerebrospinal fluid flow, such as hydrocephalus, syringomyelia, and Chiari malformation, are often found in small dogs. Although studies in human medicine have revealed a correlation with cerebrospinal fluid flow in these diseases by magnetic resonance imaging, there is little information and no standard data for normal dogs. Objectives: The purpose of this study was to obtain cerebrospinal fluid flow velocity data from the cerebral aqueduct and subarachnoid space at the foramen magnum in healthy beagle dogs. Methods: Six healthy beagle dogs were used in this experimental study. The dogs underwent phase-contrast and time-spatial labeling inversion pulse magnetic resonance imaging. Flow rate variations in the cerebrospinal fluid were observed using sagittal time-spatial labeling inversion pulse images. The pattern and velocity of cerebrospinal fluid flow were assessed using phase-contrast magnetic resonance imaging within the subarachnoid space at the foramen magnum level and the cerebral aqueduct. Results: In the ventral aspect of the subarachnoid space and cerebral aqueduct, the cerebrospinal fluid was characterized by a bidirectional flow throughout the cardiac cycle. The mean ± SD peak velocities through the ventral and dorsal aspects of the subarachnoid space and the cerebral aqueduct were 1.39 ± 0.13, 0.32 ± 0.12, and 0.76 ± 0.43 cm/s, respectively. Conclusions: Noninvasive visualization of cerebrospinal fluid flow movement with magnetic resonance imaging was feasible, and a reference dataset of cerebrospinal fluid flow peak velocities was obtained through the cervical subarachnoid space and cerebral aqueduct in healthy dogs.

Keywords

Acknowledgement

This work was supported by research fund of Chungnam National University.

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