References
- Korea Pharmaceutical Information Center. Accessed November 9, 2020, available from:URL:https://www.health.kr/researchInfo/herbalMedicine1.asp.
- Li M, Chen J, Peng Y, Wu Q, Xiao P. Investigation of Danshen and related medicinal plants in China. J Ethnopharmacol. 2008;120(3):419-26. https://doi.org/10.1016/j.jep.2008.09.013
- Pandya RS, Mao L, Zhou H, Zhou S, Zeng J, Popp AJ, Wang X. Central nervous system agents for ischemic stroke: neuroprotection mechanisms. Cent Nerv Syst Agents Med Chem. 2011;11(2):81-97. https://doi.org/10.2174/187152411796011321
- Lam BYH, Lo ACY, Sun X, Luo HW, Chung SK, Sucher NJ. Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice. Phytomedicine. 2003;10(4): 286-91. https://doi.org/10.1078/094471103322004776
- Yu X, Lin S, Zhou Z, Chen X, Liang J, Duan W, Yu X, Wen J, Chowbay B, Li C, Sheu F, Chan E, Zhou S. Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats. Neurosci Lett. 2007;417(3):261-5. https://doi.org/10.1016/j.neulet.2007.02.079
- Chien M, Chuang C, Chern C, Liou K, Liu D, Hou Y, Shen Y. Salvianolic acid A alleviates ischemic brain injury through the inhibition of inflammation and apoptosis and the promotion of neurogenesis in mice. Free Radic Biol Med. 2016;99:508-19. https://doi.org/10.1016/j.freeradbiomed.2016.09.006
- Fan Y, Luo Q, Wei J, Lin R, Lin L, Li Y, Chen Z, Lin W, Chen Q. Mechanism of salvianolic acid B neuroprotection against ischemia/ reperfusion induced cerebral injury. Brain Res. 2018;1679:125-33. https://doi.org/10.1016/j.brainres.2017.11.027
- Lee SE, Cho SI. Anti-inflammatory effects of Salviae Miltiorrhizae Radix extract on RAW264.7 cell via anti-oxidative activities. Kor J Herbol. 2015;30(4):89-94. https://doi.org/10.6116/kjh.2015.30.4.89.
- Kim GH, Hong KK, Cho HB, Choi CM, Kim SB. Anti-inflammatory effects of Salvia miltiorrhiza Water extract in RAW 264.7 Cells and mouse induced by Lipopolysaccharide. J Korean Obstet Gynecol. 2019;32(2):1-17. https://doi.org/10.15204/JKOBGY.2019.32.2.001
- Lee HG, Kim YS. Effects of Salvia Miltriorrhiza Radix on Neuronal Apoptosis following Intracerebral Hemorrhage of Rats. Kor J Herbol. 2012;27(3):89-94. https://doi.org/10.6116/kjh.2012.27.3.89
- Jeong SI, Lee JW, Jang SI. Effects of Tanshinone IIA from Salvia Miltiorrhiza Bunge on Induction of Apoptosis and Inhibition of Adipogenesis in 3T3-L1 Cells. J Physiol & Pathol Korean Med. 2009;23(6):1409-15.
- Yang SA, Im NK, Lee IS. Effects of Methanolic Extract from Salvia miltiorrhiza Bunge on in vitro Antithrombotic and Antioxidative Activities. Korean J Food SCI Technol. 2007;39(1):83-7.
- Shon YH, Cho HJ, Kim MK, Jung EJ, Nam KS. Effect of Ethanol Extract from Salvia miltiorrhiza on Chemoprevention and Metastasis of Breast Cancer. Kor J Pharmacogn 2007; 38(1):62-6.
- Lee HJ, Hong SH, Kim SH. Anti-angiogenic Effect of Cryptotanshinone through Inhibition of HIF-1alpha and STAT3 in Prostate Cancer Cells. J Physiol & Pathol Korean Med. 2012;26(4):437-40.
- Son HY, Park YK. Neuroprotective effect of modified Boyanghwano-Tang and the major medicinal plants, Astragali Radix and Salviae Miltiorrhizae Radix on ischemic stroke in rats. Kor J Herbology. 2010;25(2):71-9. https://doi.org/10.6116/KJH.2010.25.2.071
- Kim SJ, Jeong HJ, Moon PD, Lee KM, Moon BS, Hyung NY, An NH, Hong SH, Um JY, Kim HM. Effect of Danchunwhangagam on LPS or DFX-induced cytokine production in peripheral mononuclear cells of cerebral infarction patients. Immunopharmacol Immunotoxicol. 2005;27(4):683-96. https://doi.org/10.1080/08923970500418950
- Park CH, Kim YS. Effects of Salviae Miltiorrhizae Radix on Blood-Brain Barrier Impairment of ICH-Induced Rats. Kor J Herbol. 2014;29(1):19-26. https://doi.org/10.6116/kjh.2014.29.1.19
- Han SY, Kim YK. New Approach for Herbal Formula Research: Network Pharmacology. J Physiol & Pathol Korean Med. 2016;30(6):385-96. https://doi.org/10.15188/kjopp.2016.12.30.6.385
- Lab of Systems Pharmacology. TCMSP: Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. Accessed October 5, 2020, available from:URL:http://lsp.nwsuaf.edu.cn/tcmsp.php.
- STRING: Search Tool for the Retrieval of Interacting Genes/Proteins. Accessed October 24, 2020, available from:URL:https://string-db.org.
- MEIm X, Cao Y, Che Y, Li J, Shang Z, Zhao W, Qiao Y, Zhang J. Danshen: a phytochemical and pharmacological overview. Chin J Nat Med. 2019;17(1):59-80.
- Sun J, Huang SH, Tan BK, Whiteman M, Zhu YC, Wu YJ, Ng Y, Duan W, Zhu YZ. Effects of purified herbal extract of Salvia miltiorrhiza on ischemic rat myocardium after acute myocardial infarction. Life Sci. 2005;76(24): 2849-60. https://doi.org/10.1016/j.lfs.2004.11.016
- Ling S, Luo R, Dai A, Guo Z, Guo R, Komesaroff PA. A pharmaceutical preparation of Salvia miltiorrhiza protects cardiac myocytes from tumor necrosis factor-induced apoptosis and reduces angiotensin II- stimulated collagen synthesis in fibroblasts. Phytomedicine. 2009;16(1):56-64. https://doi.org/10.1016/j.phymed.2008.09.008
- Fei Y, Wang S, Yang L, Qiu Y, Li Y, Liu W, Xi T, Fang W, Li Y. Salvia miltiorrhiza Bunge (Danshen) extract attenuates permanent cerebral ischemia through inhibiting platelet activation in rats. J Ethnopharmacol. 2017; 207:57-66. https://doi.org/10.1016/j.jep.2017.06.023
- Lv H, Wang L, Shen J, Hao S, Ming A, Wang X, Su F, Zhang Z. Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats. Brain Res Bull. 2015;115:30-6. https://doi.org/10.1016/j.brainresbull.2015.05.002
- Zhou R, He L, Li Y, Shen Y, Chao R, Du J. Cardioprotective effect of water and ethanol extract of Salvia miltiorrhiza in an experimental model of myocardial infarction. J Ethnopharmacol. 2012;139(2):440-6. https://doi.org/10.1016/j.jep.2011.11.030
- Feng S, Geng J, Sun R, Huang J, Tan Z, Yan C, AA J, Wang G. Protective Effect of Salvianolic Acid A on Brain Endothelial Cells after Treatment with Deprivation and Reperfusion of Oxygen-glucose. Chin Herb Med. 2017;9(4):335-43. https://doi.org/10.1016/s1674-6384(17)60113-8
- Koizumi J. Experimental studies of ischemic brain edema. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn J Stroke. 1986;8:1-8. https://doi.org/10.3995/jstroke.8.1
- Fluri F, Schuhmann MK, Kleinschnitz C. Animal models of ischemic stroke and their application in clinical research. Drug Des Devel Ther. 2015;9:3445-54.
- Cai M, Yu Z, Wang L, Song X, Zhang J, Zhang Z, Zhang W, Li W, Xiang J, Cai D. Tongxinluo reduces brain edema and inhibits post-ischemic inflammation after middle cerebral artery occlusion in rats. J Ethnopharmacol. 2016;181:136-45. https://doi.org/10.1016/j.jep.2016.01.026
- Mo Z, Tang C, Li H, Lei J, Zhu L, Kou L, Li H, Luo S, Li C, Chen W, Zhang L. Eicosapentaenoic acid prevents inflammation induced by acute cerebral infarction through inhibition of NLRP3 inflammasome activation. Life Sci. 2020;242:117133. https://doi.org/10.1016/j.lfs.2019.117133
- Shirey JK, Brady AE, Jones PJ, Davis AA, Bridges TM, Kennedy JP, Jadhav SB, Menon UN, Xiang J, Watson ML, Christian EP, Doherty JJ, Quirk MC, Snyder DH, Lah JJ, Levey AI, Nicolle MM, Lindsley CW, Conn PJ. A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning. J Neurosci. 2009;29(45):14271-86. https://doi.org/10.1523/JNEUROSCI.3930-09.2009
- Monai H, Wang X, Yahagi K, Lou N, Mestre H, Xu Q, Abe Y, Yasui M, Iwai Y, Nedergaard M, Hirase H. Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke. Proc Natl Acad Sci. 2019;116(22):11010-9. https://doi.org/10.1073/pnas.1817347116
- Lechtenberg KJ, Meyer ST, Doyle JB, Peterson TC, Buckwalter MS. Augmented β2-adrenergic signaling dampens the neuroinflammatory response following ischemic stroke and increases stroke size. J Neuroinflammation. 2019 May 28;16(1):112-4. https://doi.org/10.1186/s12974-019-1506-4
- Lin SY, Wang YY, Chang CY, Wu CC, Chen WY, Kuan YH, Liao SL, Chen CJ. Effects of β-Adrenergic Blockade on Metabolic and Inflammatory Responses in a Rat Model of Ischemic Stroke. Cells. 2020;9(6):1373. doi:10.3390/cells9061373.
- Lu H, Tian A, Wu J, Yang C, Xing R, Jia P, Yang L, Zhang Y, Zheng X, Li Z. Danshensu inhibits β-adrenergic receptors-mediated cardiac fibrosis by ROS/p38 MAPK axis. Biol Pharm Bull. 2014;37(6):961-7. https://doi.org/10.1248/bpb.b13-00921