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The Membrane Society of Korea (한국막학회)
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Preparation of Alginate Microspheres by Rotating Membrane Emulsification

회전 막유화에 의한 알지네이트 미소 구체의 제조

  • Min, Kyoung Won (Department of Engineering Chemistry, Chungbuk National University) ;
  • Youm, Kyung Ho (Department of Engineering Chemistry, Chungbuk National University)
  • 민경원 (충북대학교 공과대학 공업화학과) ;
  • 염경호 (충북대학교 공과대학 공업화학과)
  • Received : 2021.01.17
  • Accepted : 2021.01.25
  • Published : 2021.02.28
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Abstract

When preparing calcium alginate microspheres using rotating membrane emulsification that rotates SPG (Shirasu porous glass) tubular membrane in the continuous phase, the optimal conditions of rotating membrane emulsification process parameters for producing monodisperse microspheres were determined. We determined the effects of process parameters of rotating membrane emulsification (the rotating speed of membrane module, the transmembrane pressure, the ratio of dispersed phase to continuous phase, the alginate concentration, the emulsifier concentration, the stabilizer concentration, the crosslinking agent concentration, and the membrane pore size) on the mean size and size distribution of alginate microspheres. As a result, the size of the microspheres decreased as the rotating speed of membrane module, the emulsifier concentration, and the crosslinking agent concentration increased among the process parameters of rotating membrane emulsification. On the contrary, as the ratio of dispersed phase to continuous phase, the transmembrane pressure, and the alginate concentration increased, the size of the microspheres increased. In the rotating membrane emulsification using an SPG membrane with a pore size of 3.2 ㎛, it was possible to finally prepare monodisperse alginate microspheres with a particle size of 4.5 ㎛ through the control of process parameters.

SPG (Shirasu porous glass) 원통형 막을 회전 시키는 회전 막유화를 사용하여 칼슘 알지네이트 미소 구체를 제조할 때, 단분산 미소 구체를 제조하기 위한 회전 막유화 공정변수들의 최적 조건을 결정하였다. 회전 막유화의 공정 변수로는 막의 회전 속도, 막간 압력차, 연속상에 대한 분산상의 비율, 알지네이트 농도, 유화제의 농도, 안정제 농도, 가교제 농도 및 막의 세공 크기를 설정하고, 이들 변수로 제조된 알지네이트 미소 구체의 크기와 단분산성에 미치는 영향을 검토하였다. 이 결과 회전 막유화의 공정 변수들 중에서 막모듈의 회전 속도, 유화제의 농도, 가교제의 농도가 증가 할수록 미소 구체의 크기가 감소하였으며, 반면에 연속상에 대한 분산상의 비율, 막간 압력차, 알지네이트 농도가 증가할수록 미소 구체의 크기가 증가하였다. 세공 크기 3.2 ㎛인 SPG막을 사용한 회전 막유화에서 공정변수 조절을 통해 최종적으로 입자 크기가 4.5 ㎛의 단분산 알지네이트 미소 구체의 제조가 가능하였다.

Keywords

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