DOI QR코드

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Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine

  • Deyrup, Stephen T. (Department of Chemistry and Biochemistry, Siena College) ;
  • Stagnitti, Natalie C. (Department of Chemistry and Biochemistry, Siena College) ;
  • Perpetua, Mackenzie J. (Department of Chemistry and Biochemistry, Siena College) ;
  • Wong-Deyrup, Siu Wah (The RNA Institute and Department of Biological Sciences, University at Albany, State University of New York)
  • 투고 : 2020.12.16
  • 심사 : 2021.01.04
  • 발행 : 2021.03.01

초록

Traditional Chinese medicine (TCM) was the primary source of medical treatment for the people inhabiting East Asia for thousands of years. These ancient practices have incorporated a wide variety of materia medica including plants, animals and minerals. As modern sciences, including natural products chemistry, emerged, there became increasing efforts to explore the chemistry of this materia medica to find molecules responsible for their traditional use. Insects, including beetles have played an important role in TCM. In our survey of texts and review articles on TCM materia medica, we found 48 species of beetles from 34 genera in 14 different families that are used in TCM. This review covers the chemistry known from the beetles used in TCM, or in cases where a species used in these practices has not been chemically studied, we discuss the chemistry of closely related beetles. We also found several documented uses of beetles in Traditional Korean Medicine (TKM), and included them where appropriate. There are 129 chemical constituents of beetles discussed.

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참고문헌

  1. Abernethy, D. J., Kleymenova, E. V, Rose, J., Recio, L. and Faiola, B. (2004) Human CD34 hematopoietic progenitor cells are sensitive targets for toxicity induced by 1,4-benzoquinone. Toxicol. Sci. 79, 82-89. https://doi.org/10.1093/toxsci/kfh095
  2. Ahn, M. Y., Hahn, B. S., Ryu, K. S., Kim, J. W., Kim, I. and Kim, Y. S. (2003) Purification and characterization of a serine protease with fibrinolytic activity from the dung beetles, Catharsius molossus. Thromb. Res. 112, 339-347. https://doi.org/10.1016/j.thromres.2004.01.005
  3. Akiba, T., Miyazaki, M. and Toda, N. (1986) Vasodilator actions of TRK100, a new prostaglandin I2 analogue. Br. J. Pharmacol. 89, 703-711. https://doi.org/10.1111/j.1476-5381.1986.tb11174.x
  4. Allison, J. D., Borden, J. H. and Seybold, S. J. (2004) A review of the chemical ecology of the Cerambycidae (Coleoptera). Chemoecology 14, 123-150. https://doi.org/10.1007/s00049-004-0277-1
  5. Altson, A. M. (1924) On the genital system of Lyctus brunneus Steph., with a note on Lyctus linearis Goeze (Coleoptera). Zool. J. Linn. Soc. 35, 581-597. https://doi.org/10.1111/j.1096-3642.1924.tb00056.x
  6. Berenbaum, M. R. and Eisner, T. (2008) Bugs' bugs. Science 322, 52-53. https://doi.org/10.1126/science.1164873
  7. Bessho-Uehara, M. and Oba, Y. (2017) Identification and characterization of the Luc2-type luciferase in the Japanese firefly, Luciola parvula, involved in a dim luminescence in immobile stages. Luminescence 32, 924-931. https://doi.org/10.1002/bio.3273
  8. Bologna, M. A. and Pinto, J. D. (2002) The Old World genera of Meloidae (Coleoptera): a key and synopsis. J. Nat. Hist. 36, 2013-2102. https://doi.org/10.1080/00222930110062318
  9. Bong, L. J., Neoh, K. B., Jaal, Z. and Lee, C. Y. (2015) Paederus outbreaks in human settings: a review of current knowledge. J. Med. Entomol. 52, 517-526. https://doi.org/10.1093/jme/tjv041
  10. Bouchard, P., Bousquet, Y., Davies, A. E., Alonso-Zarazaga, M. A., Lawrence, J. F., Lyal, C. H. C., Newton, A. F., Reid, C. A. M., Schmitt, M., Slipinski, S. A. and Smith, A. B. T. (2011) Family-group names in Coleoptera (Insecta). ZooKeys 88, 1-972. https://doi.org/10.3897/zookeys.88.807
  11. Brown, W., Jones, A., Lacey, M. and Moore, B. (1985) Chemistry of buprestins A and B. Bitter principles of jewel beetles (Coleoptera: Buprestidae). Aust. J. Chem. 38, 197-206. https://doi.org/10.1071/CH9850197
  12. Carrel, J. E., Doom, J. P. and McCormick, J. P. (1986) Cantharidin biosynthesis in a blister beetle: Inhibition by 6-fluoromevalonate causes chemical disarmament. Experientia 42, 853-854. https://doi.org/10.1007/BF01941552
  13. Cha, W. S., Oh, J. H., Park, H. J., Ahn, S. W., Hong, S. Y. and Kim, N. I. (2007) Historical difference between traditional Korean medicine and traditional Chinese medicine. Neurol. Res. 29 Suppl 1, S5-S9.
  14. Chan, K., Jensen, N. and O'Brien, P. J. (2008) Structure-activity relationships for thiol reactivity and rat or human hepatocyte toxicity induced by substituted p-benzoquinone compounds. J. Appl. Toxicol. 28, 608-620. https://doi.org/10.1002/jat.1312
  15. Chon, J. W., Kweon, H., Jo, Y. Y., Yeo, J. H. and Lee, H. S. (2012) Protective effects of extracts of Protaetia brevitarsis on carbon tetrachloride-induced hepatotoxicity in the mice. Korean J. Sericult. Sci. 50, 93-100.
  16. Crespo, R., Villaverde, M. L., Girotti, J. R., Guerci, A., Juarez, M. P. and De Bravo, M. G. (2011) Cytotoxic and genotoxic effects of defence secretion of Ulomoides dermestoides on A549 cells. J. Ethnopharmacol. 136, 204-209. https://doi.org/10.1016/j.jep.2011.04.056
  17. Crook, D. J., Lance, D. R. and Mastro, V. C. (2014) Identification of a potential third component of the male-produced pheromone of Anoplophora glabripennis and its effect on behavior. J. Chem. Ecol. 40, 1241-1250. https://doi.org/10.1007/s10886-014-0520-3
  18. Cunha, R. L., Verdu, J. R., Lobo, J. M. and Zardoya, R. (2011) Ancient origin of endemic Iberian earth-boring dung beetles (Geotrupidae). Mol. Phylogenet. Evol. 59, 578-586. https://doi.org/10.1016/j.ympev.2011.03.028
  19. Dai, S. X., Li, W. X., Han, F. F., Guo, Y. C., Zheng, J. J., Liu, J. Q., Wang, Q., Gao, Y. D., Li, G. H. and Huang, J. F. (2016) In silico identification of anti-cancer compounds and plants from traditional Chinese medicine database. Sci. Rep. 6, 25462. https://doi.org/10.1038/srep25462
  20. de Oliveira Pardal, P. P., da Silva, C. T. C., Monteiro, W. M. and da Costa Gadelha, M. A. (2016) Dermatitis after contact with Pheropsophus sp (Coleoptera, Carabidae, Brachininae) in the Para State, Brazilian Amazon. Rev. Soc. Bras. Med. Trop. 49, 799-801. https://doi.org/10.1590/0037-8682-0218-2016
  21. Deng, L. P., Dong, J., Cai, H. and Wang, W. (2013) Cantharidin as an antitumor agent: a retrospective review. Curr. Med. Chem. 20, 159-166. https://doi.org/10.2174/092986713804806711
  22. Dettner, K. (1985) Ecological and phylogenetic significance of defensive compounds from pygidial glands of Hydradephaga (Coleoptera). Proc. Acad. Nat. Sci. Philadelphia 137, 156-171.
  23. Dettner, K. (1987) Chemosystematics and evolution of beetle chemical defenses. Annu. Rev. Entomol. 32, 17-48. https://doi.org/10.1146/annurev.en.32.010187.000313
  24. Dettner, K. (2011) Potential pharmaceuticals from insects and their cooccurring microorganisms. In Insect Biotechnology (A. Vilcinskas, Ed.), pp. 95-119. Springer Science+Business Media.
  25. Dettner, K. (2014) Chemical ecology and biochemistry of Dytiscidae. In Ecology, Systematics, and the Natural History of Predaceous Diving Beetles (Coleoptera: Dytiscidae) (D. A. Yee, Ed.), pp. 235-306. Springer Science+Business Media.
  26. Dettner, K. (2015) Toxins, defensive compounds and drugs from insects. In Insect Molecular Biology and Ecology (K. H. Hoffmann, Ed.), pp. 39-93. Taylor & Francis.
  27. Dettner, K. (2019) Defenses of water insects. In Aquatic Insects (K. Del-Claro & R. Guillermo, Eds.), pp. 191-262. Springer Nature.
  28. Ding, Z., Zhao, Y. and Gao, X. (1997) Medicinal insects in China. Ecol. Food Nutr. 36, 209-220. https://doi.org/10.1080/03670244.1997.9991516
  29. Dong, Q. F., Wang, Z., Liu, H. J., Zhang, C. F., He, D. X., Wu, G. and Zhang, L. (2011) Flavonoid and other compounds from Holotrichia diomphalia larvae. Chem. Nat. Compd. 47, 114-115. https://doi.org/10.1007/s10600-011-9848-x
  30. Dong, Q. F., Wang, J. L., Zhang, S. F., Wang, Z., Zhang, C. X., Gao, H., Zhang, H. M. and Zhang, L. (2008) Antifungal activity of crude extracts and fat-soluble constituents of Holotrichia diomphalia larvae. Bioresour. Technol. 99, 8521-8523. https://doi.org/10.1016/j.biortech.2008.03.010
  31. Dossey, A. T. (2010) Insects and their chemical weaponry: new potential for drug discovery. Nat. Prod. Rep. 27, 1737-1757. https://doi.org/10.1039/c005319h
  32. Eisner, T., Goetz, M. A., Hill, D. E., Smedley, S. R. and Meinwald, J. (1997) Firefly "femmes fatales" acquire defensive steroids (lucibufagins) from their firefly prey. Proc. Natl. Acad. Sci. U.S.A. 94, 9723-9728. https://doi.org/10.1073/pnas.94.18.9723
  33. Eisner, T., Wiemer, D. F., Haynes, L. W. and Meinwald, J. (1978) Lucibufagins: defensive steroids from the fireflies Photinus ignitus and P. marginellus (Coleoptera: Lampyridae) Proc. Natl. Acad. Sci. U.S.A. 75, 905-908. https://doi.org/10.1073/pnas.75.2.905
  34. Eisner, T. (2003) For Love of Insects. The Belknap Press of Harvard University Press.
  35. Eisner, T., Eisner, M. and Siegler, M. (2005) Secret Weapons: Defenses of Insects, Spiders, Scorpions, and Other Many-Legged Creatures. The Belknap Press of Harvard University Press.
  36. Ernst, E. (2000) Prevalence of use of complementary/alternative medicine: a systematic review. Bull. World Health Organ. 78, 252-257.
  37. Etzler, F. E. and Johnson, P. J. (2018) Athoplastus Johnson and Etzler (Coleoptera: Elateridae: Dendrometrinae), a new genus of click beetle from the northwestern continental USA. Coleopt. Bull. 72, 503-521. https://doi.org/10.1649/0010-065x-72.3.503
  38. Fallon, T. R., Lower, S. E., Chang, C. H., Bessho-Uehara, M., Martin, G. J., Bewick, A. J., Behringer, M., Debat, H. J., Wong, I., Day, J. C., Suvorov, A., Silva, C. J., Stanger-Hall, K. F., Hall, D. W., Schmitz, R. J., Nelson, D. R., Lewis, S. M., Shigenobu, S., Bybee, S. M., Larracuente, A. M., Oba, Y. and Weng, J. K. (2018) Firefly genomes illuminate parallel origins of bioluminescence in beetles. ELife 7, e36495. https://doi.org/10.7554/elife.36495
  39. Ferraz, C. A. A., de Oliveira Junior, R. G., Picot, L., da Silva Almeida, J. R. G. and Nunes, X. P. (2019) Pre-clinical investigations of β-carboline alkaloids as antidepressant agents: a systematic review. Fitoterapia 137, 104196. https://doi.org/10.1016/j.fitote.2019.104196
  40. Fietz, O., Dettner, K., Gorls, H., Klemm, K. and Boland, W. (2002) (R)-(+)-palasonin, a cantharidin-related plant toxin, also occurs in insect hemolymph and tissues. J. Chem. Ecol. 28, 1315-1327. https://doi.org/10.1023/A:1019561517040
  41. Francke, W. and Dettner, K. (2005) Chemical signalling in beetles. In The Chemistry of Pheromones and Other Semiochemicals II (S. Schultz, Ed.), pp. 85-166.
  42. Frank, J. H. and Kanamitsu, K. (1987) Paederus, sensu lato (Coleoptera: Staphylinidae): natural history and medical importance. J. Med. Entomol. 24, 155-191. https://doi.org/10.1093/jmedent/24.2.155
  43. Fu, X., Ballantyne, L. A. and Lambkin, C. L. (2010) Aquatica gen. nov. from mainland China with a description of Aquatica wuhana sp. nov. (Coleoptera: Lampyridae: Luciolinae). Zootaxa, 2530, 1-18. https://doi.org/10.11646/zootaxa.2530.1.1
  44. Fu, X., Vencl, F. V., Nobuyoshi, O., Meyer-Rochow, V. B., Lei, C. and Zhang, Z. (2007) Structure and function of the eversible glands of the aquatic firefly Luciola leii (Coleoptera: Lampyridae). Chemoecology 17, 117-124. https://doi.org/10.1007/s00049-007-0370-3
  45. Fung, F. Y. and Linn, Y. C. (2015) Developing traditional Chinese medicine in the era of evidence-based medicine: current evidences and challenges. Evid. Based Complement. Alternat. Med. 2015, 425037.
  46. GBIF Secretariat (2019a) Chrysochroa fulgidissima (Schonherr, 1817). GBIF Backbone Taxonomy. Available from: https://doi.org/https://doi.org/10.15468/39omei/.
  47. GBIF Secretariat (2019b) Paederus fuscipes subsp. fuscipes Curtis, 1826. GBIF Backbone Taxonomy. Available from: https://doi.org/https://doi.org/10.15468/39omei/.
  48. GBIF Secretariat (2020) GBIF. Available from: https://www.gbif.org/[retrieved 2020 Jun 3].
  49. Ghoneim, K. (2013) Cantharidin toxicosis to animal and human in the world: A review. Stand. Res. J. Toxicol. Environ. Health Sci. 1, 1-16.
  50. Gustavo, E., Padin, S. B. and Stetson, R. E. (2002) First records of the Oriental species Ulomoides dermestoides (Coleoptera: Tenebrionidae) in Argentina. Rev. Soc. Entomol. Argent. 61, 48-50.
  51. Hallett, R. H., Gries, G., Gries, R., Borden, J. H., Czyzewska, E., Oehlschlager, A. C., Pierce, H. D., Angerilli, N. P. D. and Rauf, A. (1993) Aggregation pheromones of two asian palm Weevils, Rhynchophorus ferrugineus and R. vulneratus. Naturwissenschaften 80, 328-331. https://doi.org/10.1007/BF01141908
  52. Han, T., Kang, T., Jeong, J., Lee, Y., Chung, H., Park, S., Lee, S., Kim, K. and Park, H. (2012) Pseudocryptic speciation of Chrysochroa fulgidissima (Coleoptera: Buprestidae) with two new species from Korea, China and Vietnam. Zool. J. Linn. Soc. 164, 71-98. https://doi.org/10.1111/j.1096-3642.2011.00763.x
  53. Hansen, L., Xu, T., Wickham, J., Chen, Y., Hao, D., Hanks, L. M., Millar, J. G. and Teale, S. A. (2015) Identification of a male-produced pheromone component of the citrus longhorned beetle, Anoplophora chinensis. PLoS ONE 10, e0134358. https://doi.org/10.1371/journal.pone.0134358
  54. Harlin, C. (2005) To have and have not: volatile secretions make a difference in gyrinid beetle predator defence. Anim. Behav. 69, 579-585. https://doi.org/10.1016/j.anbehav.2004.06.014
  55. Hedin, P. A., Dollar, D. A., Collins, J. K., Dubois, J. G., Mulder, P. G., Hedger, G. H., Smith, M. W. and Eikenbary, R. D. (1997) Identification of male pecan weevil pheromone. J. Chem. Ecol. 23, 965-977. https://doi.org/10.1023/B:JOEC.0000006382.70034.66
  56. Holliday, A. E., Holliday, N. J., Mattingly, T. M. and Naccarato, K. M. (2012) Defensive secretions of the Carabid beetle Chlaenius cordicollis: chemical components and their geographic patterns of variation. J. Chem. Ecol. 38, 278-286. https://doi.org/10.1007/s10886-012-0078-x
  57. Hong, J. H., Kim, S. H. and Lee, Y. C. (2019) The ethanol extract of Holotrichia diomphalia larvae, containing fatty acids and amino acids, exerts anti-asthmatic effects through inhibition of the GATA-3/Th2 signaling pathway in asthmatic mice. Molecules 24, 852. https://doi.org/10.3390/molecules24050852
  58. Hong, M. Y., Jeong, H. C., Kim, M. J., Jeong, H. U., Lee, S. H. and Kim, I. (2009) Complete mitogenome sequence of the jewel beetle, Chrysochroa fulgidissima (Coleoptera: Buprestidae). Mitochondrial DNA 20, 46-60. https://doi.org/10.1080/19401730802644978
  59. Hoover, K., Keena, M., Nehme, M., Wang, S., Meng, P. and Zhang, A. (2014) Sex-specific trail pheromone mediates complex mate finding behavior in Anoplophora glabripennis. J. Chem. Ecol. 40, 169-180. https://doi.org/10.1007/s10886-014-0385-5
  60. Hosseini, H. R., Salehi, H. and Alichi, M. (2019) Acquirement of CRY8DB transgenic tall fescue (Festuca arundinacea Schreb.) by Agrobacterium tumefaciens to develop resistance against Pentodon idiota Herbest. Mol. Biotechnol. 61, 528-540. https://doi.org/10.1007/s12033-019-00183-5
  61. Houston, W. W. K. (1986) Exocrine glands in the forelegs of dung beetles in the genus Onitis F. (Coleoptera: Scarabidae). J. Austral. Ent. Soc. 25, 161-169. https://doi.org/10.1111/j.1440-6055.1986.tb01096.x
  62. Hu, Y., Kang, T. and Zhao, Z. (2004) Studies on microscopic identification of animal drugs' remnant hair (2) Identification of ground beetle and its counterfeits. Natural Medicines 58, 185-192.
  63. Huang, C., Liu, Y., Yang, J., Tian, J., Yang, L., Zhang, J., Li, Y., Li, J., Wang, C., Tu, Y. and Tao, J. (2009) An outbreak of 268 cases of Paederus dermatitis in a toy-building factory in central China. Int. J. Dermatol. 48, 128-131. https://doi.org/10.1111/j.1365-4632.2009.03876.x
  64. Hughes, G. P., Meier, L. R., Zou, Y., Millar, J. G., Hanks, L. M. and Ginzel, M. D. (2016) Stereochemistry of fuscumol and fuscumol acetate influences attraction of longhorned beetles (Coleoptera: Cerambycidae) of the subfamily Lamiinae. Environ. Entomol. 45, 1271-1275. https://doi.org/10.1093/ee/nvw101
  65. Hughes, G. P., Zou, Y., Millar, J. G. and Ginzel, M. D. (2013) (S)-fuscumol and (S)-fuscumol acetate produced by a male Astyleiopus variegatus (Coleoptera: Cerambycidae). Can. Entomol. 145, 327-332. https://doi.org/10.4039/tce.2013.3
  66. Hunt, T., Bergsten, J., Levkanicova, Z., Papadopoulou, A., St. John, O., Wild, R., Hammond, P. M., Ahrens, D., Balke, M., Caterino, M. S., Gomez-Zurita, J., Ribera, I., Barraclough, T. G., Bocakova, M., Bocak, L. and Vogler, A. P. (2007) A comprehensive phylogeny of beetles reveals the evolutionary origins of a superradiation. Science 318, 1913-1916. https://doi.org/10.1126/science.1146954
  67. Hwang, H., Patnaik, B. B., Kang, S. W., Park, S. Y., Chung, J. M., Sang, M. K., Park, J. E., Min, H. R., Seong, J., Jo, Y. H., Noh, M. Y., Lee, J. D., Jung, K. Y., Park, H. S., Jeong, H. C. and Lee, Y. S. (2018) RNA Sequencing, de novo assembly, functional annotation and SSR analysis of the endangered diving beetle Cybister chinensis (= Cybister japonicus) using the Illumina platform. Entomol. Res. 48, 60-72. https://doi.org/10.1111/1748-5967.12292
  68. Hwang, J. S., Kang, B. R., Kim, S. R., Yun, E. Y., Park, K. H., Jeon, J. P., Nam, S. H., Suh, H. J., Hong, M. Y. and Kim, I. S. (2008) Molecular characterization of a defensin-like peptide from larvae of a beetle, Protaetia brevitarsis. Int. J. Ind. Entomol. 17, 131-135.
  69. Hwang, S. Y., Kim, Y. B., Lee, S. H. and Yun, C. Y. (2005) Preventive effect of a chafer, Protaetia brevitarsis extract on carbon tetrachloride-induced liver injuries in rats. Korean J. Orient. Physiol. Pathol. 19, 1337-1343.
  70. Ide, T., Kanzaki, N., Ohmura, W. and Okabe, K. (2016) Molecular identification of an invasive wood-boring insect Lyctus brunneus (Coleoptera: Bostrichidae: Lyctinae) using frass by loop-mediated isothermal amplification and nested PCR assays. J. Econ. Entomol. 109, 1410-1414. https://doi.org/10.1093/jee/tow030
  71. Ivarsson, P., Henrikson, B. I. and Stenson, J. A. E. (1996) Volatile substances in the pygidial secretion of gyrinid beetles (Coleoptera: Gyrinidae). Chemoecology 7, 191-193. https://doi.org/10.1007/BF01266313
  72. Jach, M. A. (2003) Fried water beetles cantonese style. Am. Entomol. 49, 34-37. https://doi.org/10.1093/ae/49.1.34
  73. Jameson, M. L. (1997) Phylogenetic analysis of the subtribe Rutelina and revision of the Rutela generic groups (Coleoptera: Scarabaeidae: Rutelinae: Rutelini). Bulletin of the University of Nebraska State Museum 14, 1-184.
  74. Jang, Y. and Kim, S. (2019) Description of larva and pupa of Pentodon quadridens bidentulus (Fairmaire, 1887) (Coleoptera, Scarabaeidae, Dynastinae) and notes on its biology. Korean J. Appl. Entomol. 58, 165-174. https://doi.org/10.5656/ksae.2019.06.0.018
  75. Jasso-Villagomez, E. I., Garcia-Lorenzana, M., Almanza-Perez, J. C., Fortis-Barrera, M. A., Blancas-Flores, G., Roman-Ramos, R., Prado-Barragan, L. A. and Alarcon-Aguilar, F. J. (2018) Beetle (Ulomoides dermestoides) fat improves diabetes: effect on liver and pancreatic architecture and on PPARγexpression. Braz. J. Med. Biol. Res. 51, e7238. https://doi.org/10.1590/1414-431x20187238
  76. Jiang, M., Lu, S. M., Qi, Z. Y. and Zhang, Y. L. (2019) Characterized cantharidin distribution and related gene expression patterns in tissues of blister beetles, Epicauta chinensis. Insect Sci. 26, 240-250. https://doi.org/10.1111/1744-7917.12512
  77. Jiang, M., Lu, S. and Zhang, Y. (2017a) Characterization of juvenile hormone related genes regulating cantharidin biosynthesis in Epicauta chinensis. Sci. Rep. 7, 2308. https://doi.org/10.1038/s41598-017-02393-w
  78. Jiang, M., Lu, S. and Zhang, Y. (2017b) The potential organ involved in cantharidin biosynthesis in Epicauta chinensis Laporte (Coleoptera: Meloidae). J. Insect Sci. 17, 52. https://doi.org/10.1093/jisesa/iex021
  79. Jiang, Q., Tan, C., Ma, J. and Yang, M. (2012) Screening of active fraction of anti-benign prostatic hyperplasia from Catharsius molossus (I). Pharmacol. Clin. Chin. Mater. Med. 6, 35.
  80. Jiang, S. J. (1990) Anti-cancer insect medicinal materials in China. Zhong Yao Cai 13, 11-14.
  81. Kang, I. J., Chung, C. K., Kim, S. J., Nam, S. M. and Oh, S. H. (2001) Effects of Protaetia orientalis (Gory et Perchlon) larva on the lipid metabolism in carbon tetrachloride administered rats. Kor. Jour. Electron Microscopy 31, 9-18.
  82. Kang, J. H., Lim, C. S., Park, S. H., Seok, S. W., Yoon, T. J., Bayartogtokh, B. and Bae, Y. J. (2018) Historical domestication-driven population expansion of the dung beetle Gymnopleurus mopsus (Coleoptera: Scarabaeidae) from its last refuge in Mongolia. Sci. Rep. 8, 3963. https://doi.org/10.1038/s41598-018-22182-3
  83. Kang, N. S., Park, S. Y., Lee, K. R., Lee, S. M., Lee, B. G., Shin, D. H. and Pyo, S. (2002) Modulation of macrophage function activity by ethanolic extract of larvae of Holotrichia diomphalia. J. Ethnopharmacol. 79, 89-94. https://doi.org/10.1016/S0378-8741(01)00369-5
  84. Karlsson, A. B., Henrikson, B., Harlin, C., Ivarsson, P., Stenson, J. A. E. and Svensson, B. W. (1999) The possible role of volatile secretions as intra- and interspecific alarm signals in Gyrinus species. OIKOS 87, 220-227. https://doi.org/10.2307/3546737
  85. Karras, D. J., Farrell, S. E., Harrigan, R. A., Henretig, F. M. and Gealt, L. (1996) Poisoning from "spanish fly" (cantharidin). Am. J. Emerg. Med. 14, 478-483. https://doi.org/10.1016/S0735-6757(96)90158-8
  86. Kartika, T., Shimizu, N. and Yoshimura, T. (2015) Identification of esters as novel aggregation pheromone components produced by the male powder-post beetle, Lyctus africanus Lesne (Coleoptera: Lyctinae). PLoS ONE 10, e0141799. https://doi.org/10.1371/journal.pone.0141799
  87. Kellner, R. L. L. and Dettner, K. (1995) Allocation of pederin during lifetime of Paederus rove beetles (Coleoptera: Staphylinidae): evidence for polymorphism of hemolymph toxin. J. Chem. Ecol. 21, 1719-1733. https://doi.org/10.1007/BF02033672
  88. Kim, K. H., Kim, H. G. and Jeong, J. H. (2014a) Seasonal characteristics of eggs and adults of Luciola lateralis (Coleoptera: Lampyridae) reared in the laboratory. Korean J. Appl. Entomol. 53, 225-229. https://doi.org/10.5656/KSAE.2014.03.1.082
  89. Kim, M. J., Im, H. H., Lee, K. Y., Han, Y. S. and Kim, I. (2014b) Complete mitochondrial genome of the whiter-spotted flower chafer, Protaetia brevitarsis (Coleoptera: Scarabaeidae). Mitochondrial DNA 25, 177-178. https://doi.org/10.3109/19401736.2013.792064
  90. Kim, S. K., Hwang, U. W. and Kwon, O. (2014c) Three different genetic lineages of the jewel beetle Chrysochroa fulgidissima (Buprestidae; Chrysochroinae) inferred from mitochondrial COI gene. J. Ecol. Environ. 37, 35-39. https://doi.org/10.5141/ecoenv.2014.005
  91. Klein, M. G. and Edwards, D. C. (1989) Captures of Popillia lewisi (Coleoptera: Scarabaeidae) and other scarabs on Okinawa with Japanese beetle lures. J. Econ. Entomol. 82, 101-103. https://doi.org/10.1093/jee/82.1.101
  92. Kovac, D. and Maschwitz, U. (1990) Secretion-grooming in aquatic beetles (Hydradephaga): a chemical protection against contamination of the hydrofuge respiratory region. Chemoecology 1, 131-138. https://doi.org/10.1007/BF01241654
  93. Kumar, M., Chawla, R. and Goyal, M. (2015) Topical anesthesia. J. Anaesthesiol. Clin. Pharmacol. 31, 450-456. https://doi.org/10.4103/0970-9185.169049
  94. Kundrata, R., Gunter, N. L., Janosikova, D. and Bocak, L. (2018) Molecular evidence for the subfamilial status of Tetralobinae (Coleoptera: Elateridae), with comments on parallel evolution of some phenotypic characters. Arthropod Syst. Phylo. 76, 137-145.
  95. Leal, W. S. (1998) Chemical ecology of phytophagous scarab beetles. Annu. Rev. Entomol. 43, 39-61. https://doi.org/10.1146/annurev.ento.43.1.39
  96. Lee, H. S., Ryu, H. J., Song, H. J. and Lee, S. O. (2017a) Enzymatic preparation and antioxidant activities of protein hydrolysates from Protaetia brevitarsis larvae. J. Korean Soc. Food Sci. Nutr. 46, 1164-1170. https://doi.org/10.3746/jkfn.2017.46.10.1164
  97. Lee, H. J., Seo, M., Lee, J. H., Kim, I. W., Kim, S. Y., Hwang, J. S. and Kim, M. A. (2019) Inhibitory effect of Protaetia brevitarsis seulensis ethanol extract on neuroinflammation in LPS-stimulated BV-2 microglia. J. Life Sci. 29, 1096-1103. https://doi.org/10.5352/JLS.2019.29.10.1096
  98. Lee, J. E., Jo, D. E., Lee, A. J., Park, H. K., Youn, K., Yun, E. Y., Hwang, J. S., Jun, M. and Kang, B. H. (2014) Hepatoprotective and antineoplastic properties of Protaetia brevitarsis larvae. Entomol. Res. 44, 244-253. https://doi.org/10.1111/1748-5967.12075
  99. Lee, J. I., Hwang, I. H., Kim, J. H., Kim, M. A., Hwang, J. S., Kim, Y. H. and Na, M. K. (2017b) Quinoxaline-, dopamine-, and amino acid-derived metabolites from the edible insect Protaetia brevitarsis seulensis. Arch. Pharm. Res. 40, 1064-1070. https://doi.org/10.1007/s12272-017-0942-x
  100. Lee, J. I., Lee, W., Kim, M. A., Hwang, J. S., Na, M. K. and Bae, J. S. (2017c) Inhibition of platelet aggregation and thrombosis by indole alkaloids isolated from the edible insect Protaetia brevitarsis seulensis (Kolbe). J. Cell. Mol. Med. 21, 1217-1227. https://doi.org/10.1111/jcmm.13055
  101. Lee, S. Y., Moon, H. J., Kawabata, S., Kurata, S., Natori, S. and Lee, B. L. (1995a) A sapecin homologue of Holotrichia diomphalia: Purification, sequencing, and determination of disulfide pairs. Biol. Pharm. Bull. 18, 457-459. https://doi.org/10.1248/bpb.18.457
  102. Lee, S. Y., Moon, H. J., Kurata, S., Kurama, T., Natori, S. and Lee, B. L. (1994) Purification antibacterial diomphalial and molecular cloning of cDNA for an inducible protein of larvae of a Coleopteran insect, Holotrichia diomphalia. J. Biochem. 115, 82-86. https://doi.org/10.1093/oxfordjournals.jbchem.a124309
  103. Lee, S. Y., Moon, H. J., Kurata, S., Natori, S. and Lee, B. L. (1995b) Purification and cDNA clonging of an antifungal protein from the hemolymph of Holotrichia diomphalia larvae. Biol. Pharm. Bull. 18, 1049-1052. https://doi.org/10.1248/bpb.18.1049
  104. Li, L., Guo, C., Li, X., Xu, S. and Han, C. (2017) Microstructure and mechanical properties of rostrum in Cyrtotrachelus longimanus (Coleoptera: Curculionidae). Anim. Cells Syst. 21, 199-206. https://doi.org/10.1080/19768354.2017.1330764
  105. Liang, Z., Du, C., Yang, Y., Nong, X., Liao, H. and Yan, S. (2016) Study on antibacterial activity of male accessory-gland extracts from Cyrtotrachelus buqueti. Sichuan J. Zool. 35, 66-69.
  106. Liu, D. and Chen, Z. (2009) The effects of cantharidin and cantharidin derivates on tumour cells. Anti-Cancer Agents Med. Chem. 9, 392-396. https://doi.org/10.2174/1871520610909040392
  107. Liu, S., Sun, J., Yu, L., Zhang, C., Bi, J., Zhu, F., Qu, M. and Yang, Q. (2012) Antioxidant activity and phenolic compounds of Holotrichia parallela Motschulsky extracts. Food Chem. 134, 1885-1891. https://doi.org/10.1016/j.foodchem.2012.03.091
  108. Liu, T., Li, X., Zou, Z. Y. and Li, C. (2015) The prevalence and determinants of using Traditional Chinese Medicine among middle-aged and older Chinese adults: Results from the China health and retirement longitudinal study. J. Am. Med. Dir. Assoc. 16, 1002.e1-1002.e5. https://doi.org/10.1016/j.jamda.2015.07.011
  109. Liu, X. and Wu, N. (2004) Community features of Scarabaeoidea larvae in Stipa Grandis Steppe. Ying Yong Sheng Tai Xue Bao 15, 1607-1610.
  110. Liu, Z. C., Sun, Y. R., Wang, Z. Y. and Liu, G. F. (1985) The role of biological control in integrated management of sugarcane insect pests. Natural Enemies of Insects 7, 216-222.
  111. Liu, Z. and Liu, L. (2009) Essentials of Chinese Medicine: Volume 1 (Z. Liu and L. Liu, Eds.). Springer-Verlag London.
  112. Lu, J., Sun, Q., Tu, Z. C., Lv, Q., Shui, P. X. and Cheng, Y. X. (2015) Identification of N-acetyldopamine dimers from the dung beetle Catharsius molossus and their COX-1 and COX-2 inhibitory activities. Molecules 20, 15589-15596. https://doi.org/10.3390/molecules200915589
  113. Ma, J., Xin, C. and Tan, C. (2015) Preparation, physicochemical and pharmaceutical characterization of chitosan from Catharsius molossus residue. Int. J. Biol. Macromol. 80, 547-556. https://doi.org/10.1016/j.ijbiomac.2015.07.027
  114. Maeda, J., Kato, D. I., Arima, K., Ito, Y., Toyoda, A. and Noguchi, H. (2017) The complete mitochondrial genome sequence and phylogenetic analysis of Luciola lateralis, one of the most famous firefly in Japan (Coleoptera: Lampyridae). Mitochondrial DNA Part B 2, 546-547. https://doi.org/10.1080/23802359.2017.1365640
  115. Maier, C. A. and Ivie, M. A. (2013) Reevaluation of Chalcophora angulicollis (LeConte) and Chalcophora virginiensis (Drury) with a review and key to the North American species of Chalcophora Dejean (Coleoptera: Buprestidae). Coleopt. Bull. 67, 457-469. https://doi.org/10.1649/0010-065X-67.4.457
  116. Mang, D. Z., Luo, Q. H., Shu, M. and Wei, W. (2012) Extraction and identification of cuticular semiochemical components of Cyrtotrachelus buqueti Guerin-Meneville (Coleoptera: Curculionidae). Acta Entomol. Sin. 55, 291-302.
  117. Martin, M. M. (1979) Biochemical implications of insect mycophagy. Biol. Rev. 54, 1-21. https://doi.org/10.1111/j.1469-185X.1979.tb00865.x
  118. Martinez-Rodriguez, L. A., Bernal-Mendez, A. R., Valdovinos-Andraca, F., Martinez-Lozano, J. A., Grajales-Figueroa, G. and TellezAvila, F. I. (2015) Chinese weevils (Ulomoides dermestoides) found incidentally during colonoscopy. Endoscopy 47, E114. https://doi.org/10.1055/s-0034-1391128
  119. Martins, C. B. C., Zarbin, P. H. G. and Almeida, L. M. (2010) Evidence for sex-specific pheromones in Ulomoides dermestoides (Coleoptera, Tenebrionidae). Fla. Entomol. 93, 639-641. https://doi.org/10.1653/024.093.0424
  120. Mebs, D., Pogoda, W., Schneider, M. and Kauert, G. (2009) Cantharidin and demethylcantharidin (palasonin) content of blister beetles (Coleoptera: Meloidae) from southern Africa. Toxicon 53, 466-468. https://doi.org/10.1016/j.toxicon.2009.01.005
  121. Meier, L. R., Millar, J. G., Mongold-Diers, J. A. and Hanks, L. M. (2019) (S)-Sulcatol is a pheromone component for two species of Cerambycid beetles in the subfamily Lamiinae. J. Chem. Ecol. 45, 447-454. https://doi.org/10.1007/s10886-019-01071-7
  122. Meier, L. R., Zou, Y., Mongold-Diers, J. A., Millar, J. G. and Hanks, L. M. (2020) Pheromone composition and chemical ecology of six species of Cerambycid beetles in the subfamily Lamiinae. J. Chem. Ecol. 46, 30-39. https://doi.org/10.1007/s10886-019-01128-7
  123. Meinwald, J., Opheim, K. and Eisner, T. (1972) Gyrinidal: a sesquiterpenoid aldehyde from the defensive glands of Gyrinid beetles. Proc. Natl. Acad. Sci. U.S.A. 69, 1208-1210. https://doi.org/10.1073/pnas.69.5.1208
  124. Meyer-Rochow, V. B. (2017) Therapeutic arthropods and other, largely terrestrial, folk-medicinally important invertebrates: a comparative survey and review. J. Ethnobiol. Ethnomed. 13, 9. https://doi.org/10.1186/s13002-017-0136-0
  125. Michat, M. C., Alarie, Y. and Miller, K. B. (2017) Higher-level phylogeny of diving beetles (Coleoptera: Dytiscidae) based on larval characters. Syst. Entomol. 42, 734-767. https://doi.org/10.1111/syen.12243
  126. Miller, J. R., Hendry, L. B. and Mumma, R. O. (1975) Norsesquiterpenes as defensive toxins of whirligig beetles (Coleoptera: Gyrinidae). J. Chem. Ecol. 1, 59-82. https://doi.org/10.1007/BF00987720
  127. Miller, K. B., Bergsten, J. and Whiting, M. F. (2007) Phylogeny and classification of diving beetles in the tribe Cybistrini (Coleoptera, Dytiscidae, Dytiscinae). Zool. Scr. 36, 41-59. https://doi.org/10.1111/j.1463-6409.2006.00254.x
  128. Miyanoshita, A., Hara, S., Sugiyama, M., Asaoka, A., Taniai, K., Yukuhiro, F. and Yamakawa, M. (1996) Isolation and characterization of a new member of the insect defensin family from a beetle, Allomyrina dichotoma. Biochem. Biophys. Res. Comm. 220, 526-531. https://doi.org/10.1006/bbrc.1996.0438
  129. Moore, B. P. and Brown, W. V. (1985) The buprestins: bitter principles of jewel beetles (Coleoptera: Buprestidae). Aust. J. Entomol. 24, 81-85. https://doi.org/10.1111/j.1440-6055.1985.tb00191.x
  130. Moore, G. A., Rossi, L., Nicotera, P., Orrenius, S. and O'Brien, P. J. (1987) Quinone toxicity in hepatocytes: studies on mitochondrial Ca2+ release induced by benzoquinone derivatives. Arch. Biochem. Biophys. 259, 283-295. https://doi.org/10.1016/0003-9861(87)90495-4
  131. Mosey, R. A. and Floreancig, P. E. (2012) Isolation, biological activity, synthesis, and medicinal chemistry of the pederin/mycalamide family of natural products. Nat. Prod. Rep. 29, 980-995. https://doi.org/10.1039/c2np20052j
  132. Nakatani, T., Konishi, T., Miyahara, K. and Noda, N. (2004) Three novel cantharidin-related compounds from the Chinese blister beetle, Mylabris phalerata PALL. Chem. Pharm. Bull. 52, 807-809. https://doi.org/10.1248/cpb.52.807
  133. Namba, T. and Inagaki, K. (1984) Pharmacognostical studies on the Chinese crude drugs derived from insects (VII): on the original insects of Qicao. Shoyakugaku Zasshi 38, 118-126.
  134. Namba, T., Ma, Y. H. and Inagaki, K. (1988) Insect-derived crude drugs in the Chinese Song dynasty. J. Ethnopharmacol. 24, 247-285. https://doi.org/10.1016/0378-8741(88)90157-2
  135. Narquizian, R. and Kocienski, P. J. (2000) The pederin family of antitumor agents : structures, synthesis and biological activity. In The Role of Natural Products in Drug Discovery (J. Mulzer and R. Bohlmann, Eds.), pp. 25-56. Springer Berlin Heidelberg.
  136. National Administration of Traditional Chinese Medicine (1999) Chinese Herbal Medicine, Volume IX (Chinese Herbal Medicine Editorial Committee, Ed.). Shanghai Scientific & Technical Publishers.
  137. National Center for Complementary and Integrative Health (2019) Traditional Chinese Medicine. Available from: https://www.nccih.nih.gov/health/traditional-chinese-medicine-what-you-need-to-know/[accessed 2020 Jul 1].
  138. Natt, B. S., Campion, J. M. and Knox, K. S. (2014) Acute eosinophilic pneumonia associated with ingestion of Ulomoides dermestoides larvae ("Chinese beetles"). Ann. Am. Thorac. Soc. 11, 1667-1668. https://doi.org/10.1513/AnnalsATS.201410-483LE
  139. Nikbakhtzadeh, M. R. and Tirgari, S. (2002) Cantharidin component of Iranian blister beetles (Col: Meloidae) and their differences between Iranian and exotic species. Iranian J. Public Health 31, 113-117.
  140. Nikbakhtzadeh, M. R. and Ebrahimi, B. (2007) Detection of cantharidin-related compounds in Mylabris impressa (Coleoptera: Meloidae) J. Venom. Anim. Toxins Inc. Trop. Dis. 13, 686-693.
  141. Niogret, J., Lumaret, J. and Bertrand, M. (2018) Comparison of the cuticular profiles of several dung beetles used as host carriers by the phoretic mite Macrocheles saceri (Acari: Mesostigmata). Nat. Volatiles Essent. Oils 4, 8-13.
  142. Niogret, J., Lumaret, J. P. and Bertrand, M. (2006) Semiochemicals mediating host-finding behaviour in the phoretic association between Macrocheles saceri (Acari: Mesostigmata) and Scarabaeus species (Coleoptera: Scarabaeidae). Chemoecology 16, 129-134. https://doi.org/10.1007/s00049-006-0338-8
  143. Nishino, T., Ohgushi, R. and Ono, K. (1970) Observations on the daily fluctuation in flower visiting activity of smaller green flower chafer, Oxycetonia jucunda Falderman on citrus flowers. Japanese J. Appl. Entomol. Zool. 14, 39-44. https://doi.org/10.1303/jjaez.14.39
  144. Niu, L., Gao, J., Li, H., Liu, J. and Yin, W. (2016) Novel skeleton compound allomyrinanoid A and two purine alkaloids from the adult of Allomyrina dichotoma L. Bioorg. Med. Chem. Lett. 26, 366-369. https://doi.org/10.1016/j.bmcl.2015.12.012
  145. Noh, J. H., Yun, E. Y., Park, H., Jung, K. J., Hwang, J. S., Jeong, E. J. and Moon, K. S. (2015) Subchronic oral dose toxicity of freeze-dried powder of Allomyrina dichotoma larvae. Toxicol. Res. 31, 69-75. https://doi.org/10.5487/TR.2015.31.1.069
  146. Noh, Y. T., Baek, K. M., Shin, I. C. and Moon, I. H. (1990) Propagation of Korean fireflies, Luciola lateralis Motschulsky. Korean J. Entomol. 20, 1-9.
  147. Nowak, D. J., Pasek, J. E., Sequeira, R. A., Crane, D. E. and Mastro, V. C. (2009) Potential effect of Anoplophora glabripennis (Coleoptera: Cerambycidae) on urban trees in the United States. J. Econ. Entomol. 94, 116-122. https://doi.org/10.1603/0022-0493-94.1.116
  148. Oba, Y., Mori, N., Yoshida, M. and Inouye, S. (2010) Identification and characterization of a luciferase isotype in the Japanese firefly, Luciola cruciata, involving in the dim glow of firefly eggs. Biochemistry 49, 10788-10795. https://doi.org/10.1021/bi1016342
  149. Oberprieler, R. G., Marvaldi, A. E. and Anderson, R. S. (2007) Weevils, weevils, weevils everywhere. Zootaxa 1668, 491-520. https://doi.org/10.11646/zootaxa.1668.1.24
  150. Oh, W. Y., Pyo, S., Lee, K. R., Lee, B. K., Shin, D. H., Cho, S. I. and Lee, S. M. (2003) Effect of Holotrichia diomphalia larvae on liver fibrosis and hepatotoxicity in rats. J. Ethnopharmacol. 87, 175-180. https://doi.org/10.1016/S0378-8741(03)00140-5
  151. Pan, Z. and Ren, G. (2018) Taxonomic revision of the subfamily Meloinae (Coleoptera: Meloidae) from Xizang, China, with description of a new species. Zoological Systematics 43, 66-88.
  152. Park, H. Y., Park, D. S., Park, S. S., Oh, H. W., Shin, S. W., Lee, H. K., Joo, C. K. and Hong, S. D. (1994) Bacteria-induced antibiotic peptide, protaecin from the white-spotted flower chafer, Protaetia brevitarsis. Korean J. Appl. Microbiol. Biotechnol. 22, 52-58.
  153. Park, J. H., Kim, S. Y., Kang, M., Yoon, M., Lee, Y. I. and Park, E. (2012) Antioxidant activity and safety evaluation of juice containing Protaetia brevitarsis. J. Korean Soc. Food Sci. Nutr. 41, 41-48. https://doi.org/10.3746/JKFN.2012.41.1.041
  154. Parkin, E. A. (1940) The digestive enzymes of some wood-boring beetle larvae. J. Exp. Biol. 17, 364-377. https://doi.org/10.1242/jeb.17.4.364
  155. Pathania, M., Chandel, R. S., Verma, K. S. and Mehta, P. K. (2016) Seasonal life cycle of Holotrichia longipennis (Blanchard) (Coleoptera: Scarabaeidae: Melolonthinae): a serious foliage and root feeding pest in India. Phytoparasitica 44, 615-629. https://doi.org/10.1007/s12600-016-0557-7
  156. Pecanha, E. P., Fraga, C. A. M., De Sant' Anna, C. M. R., De Miranda, A. L. P. and Barreiro, E. J. (1998) Synthesis and pharmacological evaluation of a new class of bicyclic phospholipids, designed as platelet activating factor antagonists. Farmaco 53, 327-336. https://doi.org/10.1016/S0014-827X(98)00027-5
  157. Pemberton, R. W. (2003) Persistence and change in traditional use of insects in contemporary East Asian cultures. In Les Insects Dans La Tradition Orale - Insects in Oral Literature and Tradition (E. Motte-FLorac and J. M. C. Thomas, Eds.), pp. 139-154. Peeters.
  158. Pemberton, R. W. (1999) Insects and other arthropods used as drugs in Korean traditional medicine. J. Ethnopharmacol. 65, 207-216. https://doi.org/10.1016/S0378-8741(98)00209-8
  159. Prasher, P., Kaur, M., Singh, S., Kaur, H., Bala, M. and Sachdeva, S. (2017) Ophthalmic manifestations of Paederus dermatitis. Int. Ophthalmol. 37, 885-891. https://doi.org/10.1007/s10792-016-0352-y
  160. Puerto Galvis, C. E., Vargas Mendez, L. Y. and Kouznetsov, V. V. (2013) Cantharidin-based small molecules as potential therapeutic agents. Chem. Biol. Drug Des. 82, 477-499. https://doi.org/10.1111/cbdd.12180
  161. Ratcliffe, B. C. (2006) Scarab beetles in human culture. Coleopt. Soc. Monographs 5, 85-101.
  162. Ryczek, S., Dettner, K. and Unverzagt, C. (2009) Synthesis of buprestins D, E, F, G and H; structural confirmation and biological testing of acyl glucoses from jewel beetles (Coleoptera: Buprestidae). Bioorg. Med. Chem. 17, 1187-1192. https://doi.org/10.1016/j.bmc.2008.12.038
  163. Sagisaka, A., Miyanoshita, A., Ishibashi, J. and Yamakawa, M. (2001) Purification, characterization and gene expression of a glycine and proline-rich antibacterial protein family from larvae of a beetle, Allomyrina dichotoma. Insect Mol. Biol. 10, 293-302. https://doi.org/10.1046/j.0962-1075.2001.00261.x
  164. Saldarriaga Rivera, L., Lopez Villegas, V. and Rivera Toquica, F. (2017) Association of Ulomoides Dermestoides "beetle-peanut" as cause of palpable purpura. Revista Cubana de Reumatologia 19, 224-227.
  165. Santos, R. C. V., Lunardelli, A., Caberlon, E., Bastos, C. M. A., Nunes, F. B., Pires, M. G. S., Biolchi, V., Paul, E. L., Vieira, F. B. C., Do Carmo Aquino, A. R., Corseuil, E. and De Oliveira, J. R. (2010) Anti-inflammatory and immunomodulatory effects of Ulomoides dermestoides on induced pleurisy in rats and lymphoproliferation in vitro. Inflammation 33, 173-179. https://doi.org/10.1007/s10753-009-9171-x
  166. Schildknect, H. (1970) The defensive chemistry of land and water beetles. Angew. Chem. Int. Ed. 9, 1-9. https://doi.org/10.1002/anie.197000011
  167. Schleissner, C., Canedo, L. M., Rodriguez, P., Crespo, C., Zuniga, P., Penalver, A., De La Calle, F. and Cuevas, C. (2017) Bacterial production of a pederin analogue by a free-living marine alphaproteobacterium. J. Nat. Prod. 80, 2170-2173. https://doi.org/10.1021/acs.jnatprod.7b00408
  168. Schmitz, D. G. (1989) Cantharidin toxicosis in horses. J. Vet. Intern. Med. 3, 208-215. https://doi.org/10.1111/j.1939-1676.1989.tb00859.x
  169. Seabrooks, L. and Hu, L. (2017) Insects: an underrepresented resource for the discovery of biologically active natural products. Acta Pharmaceutica Sinica B 7, 409-426. https://doi.org/10.1016/j.apsb.2017.05.001
  170. Shibue, K., Goto, Y., Kawashima, I. and Shibue, T. (2004) Chemical analysis of surface hydrocarbons in fireflies by direct contact extraction and gas chromatography-mass spectrometry. Anal. Sci. 20, 1729-1731. https://doi.org/10.2116/analsci.20.1729
  171. Silk, P. and Ryall, K. (2015) Semiochemistry and chemical ecology of the emerald ash borer Agrilus planipennis (Coleoptera: Buprestidae). Can. Entomol. 147, 277-289. https://doi.org/10.4039/tce.2014.58
  172. Sitbon, O. and Vonk Noordegraaf, A. (2017) Epoprostenol and pulmonary arterial hypertension: 20 years of clinical experience. Eur. Respir. Rev. 26, 160055. https://doi.org/10.1183/16000617.0055-2016
  173. Smedley, S. R., Risteen, R. G., Tonyai, K. K., Pitino, J. C., Hu, Y., Ahmed, Z. B., Christofel, B. T., Gaber, M., Howells, N. R., Mosey, C. F., Rahim, F. U. and Deyrup, S. T. (2017) Bufadienolides (lucibufagins) from an ecologically aberrant firefly (Ellychnia corrusca). Chemoecology 27, 141-153. https://doi.org/10.1007/s00049-017-0240-6
  174. Song, L., Sun, S., Jin, L., Xue, L. and Fu, Y. (2014) The extracts of Holotrichia diomphalia larvae inhibit proliferation and induce apoptosis of cancer cells in vitro and in vivo. Mol. Cell. Toxicol. 10, 251-259. https://doi.org/10.1007/s13273-014-0028-5
  175. Stavenga, D. G., Wilts, B. D., Leertouwer, H. L. and Hariyama, T. (2011) Polarized iridescence of the multilayered elytra of the Japanese jewel beetle, Chrysochroa fulgidissima. Philos. Trans. R. Soc. B 366, 709-723. https://doi.org/10.1098/rstb.2010.0197
  176. Suh, H. J. and Kang, S. C. (2012) Antioxidant activity of aqueous methanol extracts of Protaetia brevitarsis Lewis (Coleoptera: Scarabaedia) at different growth stages. Nat. Prod. Res. 26, 510-517. https://doi.org/10.1080/14786419.2010.530267
  177. Suh, H. J., Kim, S. R., Lee, K. S., Park, S. and Kang, S. C. (2010) Antioxidant activity of various solvent extracts from Allomyrina dichotoma (Arthropoda: Insecta) larvae. J. Photochem. Photobiol. B 99, 67-73. https://doi.org/10.1016/j.jphotobiol.2010.02.005
  178. Sung, G. A., Kim, M. H. and Park, S. N. (2016) Anti-inflammatory and whitening effects of Protaetia brevitarsis seulensis extracts by oriental conversion methods. J. Soc. Cosmet. Sci. Korea 42, 421-432. https://doi.org/10.15230/SCSK.2016.42.4.421
  179. Tian, L., Ji, B. Z., Liu, S. W., Jin, F., Gao, J. and Li, S. (2010) Juvenile hormone III produced in male accessory glands of the longhorned beetle, Apriona germari, is transferred to female ovaries during copulation. Arch. Insect Biochem. Physiol. 75, 57-67. https://doi.org/10.1002/arch.20385
  180. Torbeck, R., Pan, M., de Moll, E. and Levitt, J. (2014) Cantharidin: a comprehensive review of the clinical literature. Dermatol. Online J. 20, 13030/qt45r512w0.
  181. Tyler, J., McKinnon, W., Lord, G. A. and Hilton, P. J. (2008) A defensive steroidal pyrone in the Glow-worm Lampyris noctiluca L. (Coleoptera: Lampyridae) Physiol. Entomol. 33, 167-170. https://doi.org/10.1111/j.1365-3032.2007.00610.x
  182. Tzeng, P., Hewson, D. J., Vukusic, P., Eichhorn, S. J. and Grunlan, J. C. (2015) Bio-inspired iridescent layer-by-layer-assembled cellulose nanocrystal Bragg stacks. J. Mater. Chem. C 3, 4260-4264. https://doi.org/10.1039/C5TC00590F
  183. Vencl, F. V., Ottens, K., Dixon, M. M., Candler, S., Bernal, X. E., Estrada, C. and Page, R. A. (2016) Pyrazine emission by a tropical firefly: an example of chemical aposematism? Biotropica 48, 645-655. https://doi.org/10.1111/btp.12336
  184. Villaverde, M. L., Girotti, J. R., Mijailovsky, S. J., Pedrini, N. and Juarez, M. P. (2009) Volatile secretions and epicuticular hydrocarbons of the beetle Ulomoides dermestoides. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 154, 381-386. https://doi.org/10.1016/j.cbpb.2009.08.001
  185. Vuts, J., Imrei, Z., Birkett, M. A., Pickett, J. A., Woodcock, C. M. and Toth, M. (2014) Semiochemistry of the Scarabaeoidea. J. Chem. Ecol. 40, 190-210. https://doi.org/10.1007/s10886-014-0377-5
  186. Wahid, A. A. A., Maged, M. and Mohamed, A. F. (2018) Evaluation of Scarabaeus sacer derived-chitosan, anti-cancer potentials and related changes: in vitro study. J. Egypt. Soc. Parasitol. 48, 443-448. https://doi.org/10.12816/0050452
  187. Wahrendorf, M. S. and Wink, M. (2006) Pharmacologically active natural products in the defence secretion of Palembus ocularis (Tenebrionidae, Coleoptera). J. Ethnopharmacol. 106, 51-56. https://doi.org/10.1016/j.jep.2005.12.007
  188. Walter, W. G. and Cole, J. F. (1967) Isolation of cantharidin from Epicauta pestifera. J. Pharm. Sci. 56, 174-176. https://doi.org/10.1002/jps.2600560204
  189. Wang, C. Q., Li, J. Q., Li, E. T., Nyamwasa, I., Li, K. Bin, Zhang, S., Peng, Y., Wei, Z. J. and Yin, J. (2019a) Molecular and functional characterization of odorant-binding protein genes in Holotrichia oblita Faldermann. Int. J. Biol. Macromol. 136, 359-367. https://doi.org/10.1016/j.ijbiomac.2019.06.013
  190. Wang, G. S. (1989) Medical uses of Mylabris in ancient China and recent studies. J. Ethnopharmacol. 26, 147-162. https://doi.org/10.1016/0378-8741(89)90062-7
  191. Wang, J., Yan, Y., Tan, R. and Cheng, Y. (2012) Phenolic compounds from Holotrichia diomphalia Bates. Nat. Prod. Res. Dev. 24, 622-626. https://doi.org/10.3969/j.issn.1001-6880.2012.05.011
  192. Wang, K., Li, P., Gao, Y., Liu, C., Wang, Q., Yin, J., Zhang, J., Geng, L. and Shu, C. (2019b) De novo genome assembly of the white-spotted flower chafer (Protaetia brevitarsis). GigaScience 8, giz019.
  193. Wang, X., Wang, T., Sun, Y. and Wang, S. (2017) Preliminary construction of the behavior spectrum of Cybister Japonicus Sharp under artificial breeding conditions. Ad. Eng. Res. 141, 1507-1510.
  194. Wickham, J. D., Xu, Z. and Teale, S. A. (2012) Evidence for a female-produced, long range pheromone of Anoplophora glabripennis (Coleoptera: Cerambycidae). Insect Sci. 19, 355-371. https://doi.org/10.1111/j.1744-7917.2012.01504.x
  195. Wu, Z., Hong, C., Jin, C., Zhang, T., Yin, J., Wang, J. and Wu, M. (1996) Effect of Martianus dermestoides on coagulation and bleeding time in mice. Zhong Yao Cai 7, 18.
  196. Xin, C., Ma, J. H., Tan, C. J., Yang, Z., Ye, F., Long, C., Ye, S. and Hou, D. B. (2015) Preparation of melanin from Catharsius molossus L. and preliminary study on its chemical structure. J.Biosci. Bioeng. 119, 446-454. https://doi.org/10.1016/j.jbiosc.2014.09.009
  197. Xu, M. Z., Lee, W. S., Han, J. M., Oh, H. W., Park, D. S., Tian, G. R., Jeong, T. S. and Park, H. Y. (2006) Antioxidant and anti-inflammatory activities of N-acetyldopamine dimers from Periostracum Cicadae. Bioorg. Med. Chem. 14, 7826-7834. https://doi.org/10.1016/j.bmc.2006.07.063
  198. Xu, X., Liu, W., Li, W. and Liu, S. (2016) Anticoagulant activity of crude extract of Holotrichia diomphalia larvae. J. Ethnopharmacol. 177, 28-34. https://doi.org/10.1016/j.jep.2015.11.015
  199. Yan, S. C., Wang, L., Li, Q. and Fu, Y. (2009) Anti-senile effects of water extraction of Martianus dermestoides (Coleoptera: Tenebrionidae) feeding different foods on aging mice. Acta Entomologica Sinica 52, 820-824. https://doi.org/10.3321/j.issn:0454-6296.2009.07.016
  200. Yan, Y. M., Li, L. J., Qin, X. C., Lu, Q., Tu, Z. C. and Cheng, Y. X. (2015) Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities. Bioorg. Med. Chem. Lett. 25, 2469-2472. https://doi.org/10.1016/j.bmcl.2015.04.085
  201. Yang, S. (1998) The Divine Farmer's Materia Medica A: Translation of the Shen Nong Ben Cao Jing (7th ed.). Blue Poppy Press.
  202. Yang, W. J., Yang, D. X., Xu, K. K., Cao, Y., Meng, Y. L., Wu, Y., Li, G. Y., Zhang, G. Z., Wang, Y. W. and Li, C. (2018) Complete mitochondrial genome of the bamboo snout beetle, Cyrotrachelus buqueti (Coleoptera: Curculionidae). Mitochondrial DNA Part B 3, 88-89. https://doi.org/10.1080/23802359.2017.1422411
  203. Yasui, H. (2009) Chemical communication in mate location and recognition in the white-spotted longicorn beetle, Anoplophora malasiaca (Coleoptera: Cerambycidae). Appl. Entomol. Zool. 44, 183-194. https://doi.org/10.1303/aez.2009.183
  204. Yasui, H., Akino, T., Yasuda, T., Fukaya, M., Ono, H. and Wakamura, S. (2003) Ketone components in the contact sex pheromone of the white-spotted longicorn beetle, Anoplophora malasiaca, and pheromonal activity of synthetic ketones. Entomol. Exp. Appl. 107, 167-176. https://doi.org/10.1046/j.1570-7458.2003.00053.x
  205. Yasui, H., Akino, T., Yasuda, T., Fukaya, M., Wakamura, S. and Ono, H. (2007) Gomadalactones A, B, and C: novel 3-oxabicyclo[3.3.0] octane compounds in the contact sex pheromone of the whitespotted longicorn beetle, Anoplophora malasiaca. Tetrahedron Lett. 48, 2395-2400. https://doi.org/10.1016/j.tetlet.2007.01.101
  206. Yeo, H., Youn, K., Kim, M., Yun, E. Y., Hwang, J. S., Jeong, W. S. and Jun, M. (2013) Fatty acid composition and volatile constituents of Protaetia brevitarsis larvae. Prev. Nutr. Food Sci. 18, 150-156. https://doi.org/10.3746/pnf.2013.18.2.150
  207. Yoo, Y. C., Shin, B. H., Hong, J. H., Lee, J., Chee, H. Y., Song, K. S. and Lee, K. B. (2007) Isolation of fatty acids with anticancer activity from Protaetia brevitarsis larva. Arch. Pharm. Res. 30, 361-365. https://doi.org/10.1007/BF02977619
  208. Yoon, H. S., Lee, C. S., Lee, S. Y., Choi, C. S., Lee, I. H., Yeo, S. M. and Kim, H. R. (2003) Purification and cDNA cloning of inducible antibacterial peptides from Protaetia brevitarsis (Coleoptera). Arch. Insect Biochem. Physiol. 52, 92-103. https://doi.org/10.1002/arch.10072
  209. Yoon, Y. Il, Chung, M. Y., Hwang, J. S., Han, M. S., Goo, T. W. and Yun, E. Y. (2015) Allomyrina dichotoma (arthropoda: Insecta) larvae confer resistance to obesity in mice fed a high-fat diet. Nutrients 7, 1978-1991. https://doi.org/10.3390/nu7031978
  210. Yoshioka, S., Kinoshita, S., Iida, H. and Hariyama, T. (2012) Phaseadjusting layers in the multilayer reflector of a jewel beetle. J. Phys. Soc. Jpn. 81, 054801. https://doi.org/10.1143/JPSJ.81.054801
  211. You, D. O., Kang, J. D., Youn, N. H. and Park, S. D. (2003) Bullous contact dermatitis caused by self-applied crushed Paederus fuscipes for the treatment of vitiligo. Cutis 72, 385-388.
  212. Youn, K., Kim, J. Y., Yeo, H., Yun, E. Y., Hwang, J. S. and Jun, M. (2012) Fatty acid and volatile oil compositions of Allomyrina dichotoma larvae. Prev. Nutr. Food Sci. 17, 310-314. https://doi.org/10.3746/pnf.2012.17.4.310
  213. Young, D. K. (1984) Cantharidin and insects: an historical review. Great Lakes Entomol. 17, 187-194.
  214. Yuan, M. L., Zhang, Q. L., Zhang, L., Guo, Z. L., Liu, Y. J., Shen, Y. Y. and Shao, R. (2016) High-level phylogeny of the Coleoptera inferred with mitochondrial genome sequences. Mol. Phylogenet. Evol. 104, 99-111. https://doi.org/10.1016/j.ympev.2016.08.002
  215. Zeng, Y., Guo, Y., Zhang, Y., Wang, X., Jiang, Y. and Yang, D. (2020) Rapid profiling of cantharidin analogs in Mylabris phalerata Pallas by ultra-performance liquid chromatography-quadrupole time-of-flight-tandem mass spectrometry. Biomed. Chromatogr. 34, e4801. https://doi.org/10.1002/bmc.4801
  216. Zhang, A., Oliver, J. E., Aldrich, J. R., Wang, B. and Mastro, V. C. (2002) Stimulatory beetle volatiles for the Asian longhorned beetle, Anoplophora glabripennis (Motschulsky). Z. Naturforsch. C 57, 553-558. https://doi.org/10.1515/znc-2002-5-626
  217. Zhang, A., Oliver, J. E., Chauhan, K., Zhao, B., Xia, L. and Xu, Z. (2003) Evidence for contact sex recognition pheromone of the Asian longhorned beetle, Anoplophora glabripennis (Coleoptera: Cerambycidae). Naturwissenschaften 90, 410-413. https://doi.org/10.1007/s00114-003-0452-1
  218. Zhang, X., Ruan, J. and Ma, Z. (2019) Research on history and present situation of medicinal insect resources in China. Chinese Journal of Bioprocess Engineering 17, 615-622.
  219. Zhang, Z., Zhang, X., Zhao, Y., Mu, W. and Liu, F. (2017) Efficacy of insecticidal seed treatments against the wireworm Pleonomus canaliculatus (Coleoptera: Elateridae) in China. Crop Prot. 92, 134-142. https://doi.org/10.1016/j.cropro.2016.11.004
  220. Zhao, X., Zhu, M., Yang, M., Tao, K. and Wang, J. (2006) The study of Catharsius molossus L. on experimental prostatic hyperplasia. Pharmacol. Clin. Chin. Mater. Med. 22, 37.

피인용 문헌

  1. Antiparasitic Effects of Potentially Toxic Beetles (Tenebrionidae and Meloidae) from Steppe Zones vol.13, pp.7, 2021, https://doi.org/10.3390/toxins13070489