CELLMED (셀메드)

Cellmed Orthocellular Medicine and Pharmaceutical Association (셀메드 세포교정의약학회)
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An In sight into Novel Drug Delivery System: In Situ Gels

  • Bashir, Rabiah (Department of Pharmaceutical Sciences, University Of Kashmir) ;
  • Maqbool, Mudasir (Department of Pharmaceutical Sciences, University Of Kashmir) ;
  • Ara, Irfat (Regional Research Institute of Unani Medicine) ;
  • Zehravi, Mehrukh (Department of Clinical Pharmacy Girls Section, Prince Sattam Bin Abdul Aziz University Alkharj)
  • Received : 2021.02.08
  • Accepted : 2021.02.19
  • Published : 2021.02.26
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Abstract

In situ gelling devices, as they enter the body, are dosage forms in the shape of the sol but turn into gel types under physiological circumstances. Transition from sol to gel is contingent on one or a mixture of diverse stimuli, such as transition of pH control of temperature, irradiation by UV, by the occurrence of certain ions or molecules. Such characteristic features may be commonly employed in drug delivery systems for the production of bioactive molecules for continuous delivery vehicles. The technique of in situ gelling has been shown to be impactful in enhancing the potency of local or systemic drugs supplied by non-parenteral pathways, increasing their period of residence at the absorption site. Formulation efficacy is further improved with the use of mucoadhesive agents or the use of polymers with both in situ gelling properties and the ability to bind with the mucosa/mucus. The most popular and common approach in recent years has provided by the use of polymers with different in situ gelation mechanisms for synergistic action between polymers in the same formulation. In situ gelling medicine systems in recent decades have received considerable interest. Until administration, it is in a sol-zone and is able to form gels in response to various endogenous factors, for e.g elevated temperature, pH changes and ions. Such systems can be used in various ways for local or systemic supply of drugs and successfully also as vehicles for drug-induced nano- and micro-particles. In this review we will discuss about various aspects about use of these in situ gels as novel drug delivery systems.

Keywords

References

  1. Adler, C., et al. The effect of viscosity of the vehicle on the penetration of fluorescein into the human eye. Experimental eye research, 1971;11(1): 34-42. https://doi.org/10.1016/S0014-4835(71)80062-3
  2. Aikawa, K., et al. Drug release from pH-response polyvinylacetal diethylaminoacetate hydrogel, and application to nasal delivery. International journal of pharmaceutics, 1998; 168(2): 181-188. https://doi.org/10.1016/S0378-5173(98)00096-9
  3. Alexandridis, P. and B. Lindman. Amphiphilic block copolymers: self-assembly and applications, Elsevier, 2000.
  4. Bashir, R., et al. Floating oral in-situ gel: a review, Journal of Drug Delivery and Therapeutics, 2019;9(2): 442-448. https://doi.org/10.22270/jddt.v9i2.2372
  5. Bhardwaj, TR., et al. Natural gums and modified natural gums as sustained-release carriers, Drug development and industrial pharmacy, 2000;26(10): 1025-1038. https://doi.org/10.1081/DDC-100100266
  6. Bilensoy, E., et al. Mucoadhesive, thermosensitive, prolongedrelease vaginal gel for clotrimazole: β-cyclodextrin complex, AAPS PharmSciTech. 2006;7(2): E54-E60. https://doi.org/10.1208/pt070238
  7. Bromberg, LE. and E. S. Ron. Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery, Advanced drug delivery reviews, 1998;31(3): 197-221. https://doi.org/10.1016/S0169-409X(97)00121-X
  8. Burkoth, AK. and KS. Anseth. A review of photocrosslinked polyanhydrides:: in situ forming degradable networks, Biomaterials, 2000; 21(23): 2395-2404. https://doi.org/10.1016/S0142-9612(00)00107-1
  9. Cao, S.-l., et al. In situ gel based on gellan gum as new carrier for nasal administration of mometasone furoate, International journal of pharmaceutics, 2009;365(1-2): 109-115. https://doi.org/10.1016/j.ijpharm.2008.08.042
  10. Cappello, J., et al. In-situ self-assembling protein polymer gel systems for administration, delivery, and release of drugs, Journal of controlled release, 1998; 53(1-3): 105-117. https://doi.org/10.1016/S0168-3659(97)00243-5
  11. Carelli, V., et al. Silicone microspheres for pH-controlled gastrointestinal drug delivery, International journal of pharmaceutics, 1999; 179(1): 73-83. https://doi.org/10.1016/S0378-5173(98)00387-1
  12. Chang, JY., et al. Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis, Journal of controlled release, 2002; 82(1): 39-50. https://doi.org/10.1016/S0168-3659(02)00086-X
  13. Choi, HG., et al. Effect of additives on the physicochemical properties of liquid suppository bases, International journal of pharmaceutics, 1999; 190(1): 13-19. https://doi.org/10.1016/S0378-5173(99)00225-2
  14. DesNoyer, JR. and A. J. McHugh. The effect of Pluronic on the protein release kinetics of an injectable drug delivery system, Journal of controlled release, 2003; 86(1): 15-24. https://doi.org/10.1016/S0168-3659(02)00293-6
  15. Durrani, A., et al. Pilocarpine bioavailability from a mucoadhesive liposomal ophthalmic drug delivery system, International journal of pharmaceutics, 1992; 88(1-3): 409-415. https://doi.org/10.1016/0378-5173(92)90340-8
  16. Esposito, E., et al. Comparative analysis of tetracycline-containing dental gels: poloxamer-and monoglyceride-based formulations, International journal of pharmaceutics, 1996; 142(1): 9-23. https://doi.org/10.1016/0378-5173(96)04649-2
  17. Geraghty, P., et al. An investigation of the parameters influencing the bioadhesive properties of Myverol 18-99/water gels, Biomaterials, 1997; 18(1): 63-67. https://doi.org/10.1016/S0142-9612(96)00087-7
  18. Guo, JH., et al. Pharmaceutical applications of naturally occurring water-soluble polymers, Pharmaceutical science & technology today, 1998; 1(6): 254-261. https://doi.org/10.1016/S1461-5347(98)00072-8
  19. HB, N., et al. In-situ gel: new trends in controlled and sustained drug delivery system, International Journal of PharmTech Research, 2010; 2(2): 1398-1408.
  20. Huffman, AS., et al. Thermally reversible hydrogels: II. Delivery and selective removal of substances from aqueous solutions, Journal of controlled release, 1986; 4(3): 213-222.
  21. Ito, T., et al. The prevention of peritoneal adhesions by in situ cross-linking hydrogels of hyaluronic acid and cellulose derivatives, Biomaterials, 2007; 28(6): 975-983. https://doi.org/10.1016/j.biomaterials.2006.10.021
  22. Jain, S. and D. Jain. Narrative treatment of GERD: focus on the lower esophageal sphincter (LES) using raft forming in-situ gelling system, Journal of Biomedical and Therapeutic Sciences, 2017; 4(1): 11-20.
  23. Kubo, W., et al. Oral sustained delivery of paracetamol from in situ-gelling gellan and sodium alginate formulations, International journal of pharmaceutics, 2003; 258(1-2): 55-64. https://doi.org/10.1016/S0378-5173(03)00163-7
  24. Kumar, S. and KJ. Himmelstein. Modification of in situ gelling behavior of carbopol solutions by hydroxypropyl methylcellulose, Journal of pharmaceutical sciences, 1995; 84(3): 344-348. https://doi.org/10.1002/jps.2600840315
  25. Majeed, A., et al. Preparation, characterization and applications of nanoemulsions: An insight, Journal of Drug Delivery and Therapeutics, 2019; 9(2): 520-527. https://doi.org/10.22270/jddt.v9i2.2410
  26. Maqbool, M., et al. The Pattern of Substance Abuse in the Psychiatry Department of a Tertiary Care of Srinagar Hospital, Jammu and Kashmir, India, Archives of Neuroscience, 2020; 7(4).
  27. Miyazaki, S., et al. In situ-gelling gellan formulations as vehicles for oral drug delivery, Journal of controlled release, 1999; 60(2-3): 287-295. https://doi.org/10.1016/S0168-3659(99)00084-X
  28. Miyazaki, S., et al. Comparison of in situ gelling formulations for the oral delivery of cimetidine, International journal of pharmaceutics, 2001; 220(1-2): 161-168. https://doi.org/10.1016/S0378-5173(01)00669-X
  29. Miyazaki, S., et al. Thermally reversible xyloglucan gels as vehicles for rectal drug delivery, Journal of controlled release, 1998; 56(1-3): 75-83. https://doi.org/10.1016/S0168-3659(98)00079-0
  30. Mohd, M., et al. Polycystic Ovary Syndrome, a modern epidemic: An overview, Journal of Drug Delivery and Therapeutics, 2019; 9(3): 641-644.
  31. Mottu, F., et al. In vitro assessment of new embolic liquids prepared from preformed polymers and water-miscible solvents for aneurysm treatment, Biomaterials, 2000; 21(8): 803-811. https://doi.org/10.1016/S0142-9612(99)00243-4
  32. Parekh, K. and K. Shah. FORMULATION DEVELOPMENT AND EVALUATION OF ORAL IN-SITU FLOATING GEL OF DOMPERIDONE, Pharma Science Monitor, 2013; 3(3).
  33. Patel, JKP., et al. Floating in situ gel based on alginate as carrier for stomach-specific drug delivery of famotidine, International Journal of Pharmaceutical Sciences and Nanotechnology, 2010; 3(3): 1092-1104. https://doi.org/10.37285/ijpsn.2010.3.3.7
  34. Patel, N., et al. Floating drug delivery system: an innovative acceptable approach in gastro retentive drug delivery, Asian J. Pharm. Res, 2012; 2(1): 07-18.
  35. Podual, K., et al. Dynamic behavior of glucose oxidase-containing microparticles of poly (ethylene glycol)-grafted cationic hydrogels in an environment of changing pH, Biomaterials, 2000; 21(14): 1439-1450. https://doi.org/10.1016/S0142-9612(00)00020-X
  36. Qiu, Y. and K. Park. Environment-sensitive hydrogels for drug delivery, Advanced drug delivery reviews, 2001; 53(3): 321-339. https://doi.org/10.1016/S0169-409X(01)00203-4
  37. Rajinikanth, P. and B. Mishra. Floating in situ gelling system for stomach site-specific delivery of clarithromycin to eradicate H. pylori, Journal of controlled release, 2008; 125(1): 33-41. https://doi.org/10.1016/j.jconrel.2007.07.011
  38. Rathi, RC., et al. Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties, Google Patents, 2001.
  39. Ricci, E., et al. Rheological characterization of Poloxamer 407 lidocaine hydrochloride gels, European Journal of Pharmaceutical Sciences, 2002; 17(3): 161-167. https://doi.org/10.1016/S0928-0987(02)00166-5
  40. Schmolka, IR. Artificial skin I. Preparation and properties of pluronic F‐127 gels for treatment of burns, Journal of biomedical materials research, 1972; 6(6): 571-582. https://doi.org/10.1002/jbm.820060609
  41. Schoenwald, RD. and VF. Smolen. Drug-absorption analysis from pharmacological data II: Transcorneal biophasic availability of tropicamide, Journal of pharmaceutical sciences, 1971; 60(7): 1039-1045. https://doi.org/10.1002/jps.2600600708
  42. Shah, SH., et al. Gastroretentive floating drug delivery systems with potential herbal drugs for Helicobacter pylori eradication: a review, Journal of Chinese Integrative Medicine, 2009; 7(10): 976-982. https://doi.org/10.3736/jcim20091012
  43. Soppimath, KS., et al. Stimulus-responsive "smart" hydrogels as novel drug delivery systems, Drug development and industrial pharmacy, 2002; 28(8): 957-974. https://doi.org/10.1081/DDC-120006428
  44. Swapnali, R., et al. A novel approach of gastroretentive drug delivery: in situ gel, Journal of Innovations in Pharmaceuticals and Biological Sciences, 2014; 1(1): 39-59.
  45. Talukder, R. and R. Fassihi. Gastroretentive delivery systems: A mini review, Drug development and industrial pharmacy, 2004; 30(10): 1019-1028. https://doi.org/10.1081/DDC-200040239
  46. Wu, J., et al. A thermosensitive hydrogel based on quaternized chitosan and poly (ethylene glycol) for nasal drug delivery system, Biomaterials, 2007; 28(13): 2220-2232. https://doi.org/10.1016/j.biomaterials.2006.12.024