참고문헌
- Torre LA, Siegel RL, Jemal A. Lung cancer statistics. Adv Exp Med Biol 2016;893:1-19. https://doi.org/10.1007/978-3-319-24223-1_1
- Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014;64(1):9-29. https://doi.org/10.3322/caac.21208
- Reck M, Heigener DF, Mok T, Soria J-C, Rabe KF. Management of non-small-cell lung cancer: recent developments. The Lancet 2013;382(9893):709-19. https://doi.org/10.1016/S0140-6736(13)61502-0
- Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell 2011;147(2):275-92. https://doi.org/10.1016/j.cell.2011.09.024
- Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002;2(6):442-54. https://doi.org/10.1038/nrc822
- Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009;139(5):871-90. https://doi.org/10.1016/j.cell.2009.11.007
- Batlle E, Sancho E, Franci C, DomingueZ D, Monfar M, Baulida J, Herreros AG. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2000;2(2):84-9. https://doi.org/10.1038/35000034
- Humbert PO, Grzeschik NA, Brumby AM, Galea R, Elsum I, Richardson HE. Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module. Oncogene 2008;27(55):6888-907. https://doi.org/10.1038/onc.2008.341
- Birchmeier W, Behrens J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1994;1198(1):11-26. https://doi.org/10.1016/0304-419X(94)90003-5
- Fong YC, Hsu SF, Wu CL, Li TM, Kao ST, Tsai FJ, Chen WC, Liu SC, Wu CM, Tang CH. Transforming growth factor-beta1 increases cell migration and beta1 integrin up-regulation in human lung cancer cells. Lung Cancer 2009;64(1):13-21. https://doi.org/10.1016/j.lungcan.2008.07.010
- Massague J. TGF-beta signalling in context. Nat Rev Mol Cell Biol 2012;13(10): 616-30. https://doi.org/10.1038/nrm3434
- Liu X, Yun F, Shi L, Li Z-H, Luo N-R, Jia Y-F. Roles of signaling pathways in the epithelial-mesenchymal transition in cancer. Asian Pac J Cancer Prev 2015;16(15):6201-6. https://doi.org/10.7314/APJCP.2015.16.15.6201
- Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008;133(4):704-15. https://doi.org/10.1016/j.cell.2008.03.027
- Monteiro J, Fodde R. Cancer stemness and metastasis: therapeutic consequences and perspectives. Eur J Cancer 2010;46(7):1198-203. https://doi.org/10.1016/j.ejca.2010.02.030
- Bent S, Ko R. Commonly used herbal medicines in the United States: a review. Am J Med 2004;116(7):478-85. https://doi.org/10.1016/j.amjmed.2003.10.036
- Nocerino E, Amato M, Izzo AA. The aphrodisiac and adaptogenic properties of ginseng. Fitoterapia 2000;71(Suppl 1):S1-5. https://doi.org/10.1016/S0367-326X(00)00170-2
- Huang YC, Chen CT, Chen SC, Lai PH, Liang HC, Chang Y, Yu LC, Sung HW. A natural compound (ginsenoside Re) isolated from Panax ginseng as a novel angiogenic agent for tissue regeneration. Pharm Res 2005;22(4):636-46. https://doi.org/10.1007/s11095-005-2500-3
- Kim KR, Chung TY, Shin H, Son SH, Park KK, Choi JH, Chung WY. Red ginseng saponin extract attenuates murine collagen-induced arthritis by reducing pro-inflammatory responses and matrix metalloproteinase-3 expression. Biol. Pharm. Bull. 2010;33(4):604-10. https://doi.org/10.1248/bpb.33.604
- Choi P, Park JY, Kim T, Park S-H, Kim H-k, Kang KS, Ham J. Improved anticancer effect of ginseng extract by microwave-assisted processing through the generation of ginsenosides Rg3, Rg5 and Rk1. J Funct Foods 2015;14:613-22. https://doi.org/10.1016/j.jff.2015.02.038
- Kim YJ, Yamabe N, Choi P, Lee JW, Ham J, Kang KS. Efficient thermal deglycosylation of ginsenoside Rd and its contribution to the improved anticancer activity of ginseng. J Agric Food Chem 2013;61(38):9185-91. https://doi.org/10.1021/jf402774d
- Ko H, Kim S, Yang K, Kim K. Phosphorylation-dependent stabilization of MZF1 upregulates N-cadherin expression during protein kinase CK2-mediated epithelial-mesenchymal transition. Oncogenesis 2018;7(3):27. https://doi.org/10.1038/s41389-018-0035-9
- Kim YJ, Choi WI, Jeon BN, Choi KC, Kim K, Kim TJ, Ham J, Jang HJ, Kang KS, Ko H. Stereospecific effects of ginsenoside 20-Rg3 inhibits TGF-beta1-induced epithelial-mesenchymal transition and suppresses lung cancer migration, invasion and anoikis resistance. Toxicology 2014;322:23-33. https://doi.org/10.1016/j.tox.2014.04.002
- Lim WC, Kim H, Kim YJ, Choi KC, Lee IH, Lee KH, Kim MK, Ko H. Dioscin suppresses TGF-beta1-induced epithelial-mesenchymal transition and suppresses A549 lung cancer migration and invasion. Bioorg Med Chem Lett 2017;27(15):3342-8. https://doi.org/10.1016/j.bmcl.2017.06.014
- Frisch SM, Schaller M, Cieply B. Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis. J Cell Sci 2013;126(Pt 1):21-9. https://doi.org/10.1242/jcs.120907
- Kim YJ, Jeon Y, Kim T, Lim WC, Ham J, Park YN, Kim TJ, Ko H. Combined treatment with zingerone and its novel derivative synergistically inhibits TGF-beta1 induced epithelial-mesenchymal transition, migration and invasion of human hepatocellular carcinoma cells. Bioorg Med Chem Lett 2017;27(4): 1081-8. https://doi.org/10.1016/j.bmc1.2016.12.042
- Hayden MS, Ghosh S. Regulation of NF-kappaB by TNF family cytokines. Semin Immunol 2014;26(3):253-66. https://doi.org/10.1016/j.smim.2014.05.004
- Hadler-Olsen E, Winberg J-O, Uhlin-Hansen LJTB. Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets 2013;34(4):2041-51. https://doi.org/10.1007/s13277-013-0842-8
- Smith AL, Robin TP, Ford HL. Molecular pathways: targeting the TGF-beta pathway for cancer therapy. Clin Cancer Res 2012;18(17):4514-21. https://doi.org/10.1158/1078-0432.ccr-11-3224
- Hsieh HL, Wang HH, Wu WB, Chu PJ, Yang CM. Transforming growth factorbeta1 induces matrix metalloproteinase-9 and cell migration in astrocytes: roles of ROS-dependent ERK- and JNK-NF-kappaB pathways. J Neuroinflammation 2010;7:88. https://doi.org/10.1186/1742-2094-7-88
- Chen HH, Zhou XL, Shi YL, Yang J. Roles of p38 MAPK and JNK in TGF-beta1-induced human alveolar epithelial to mesenchymal transition. Arch Med Res 2013;44(2):93-8. https://doi.org/10.1016/j.arcmed.2013.01.004
- Huang X, Chen S, Xu L, Liu Y, Deb DK, Platanias LC, Bergan RC. Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells. Cancer Res 2005;65(8):3470-8. https://doi.org/10.1158/0008-5472.CAN-04-2807
- Ma L, Teruya-Feldstein J, Weinberg RA. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007;449(7163):682-8. https://doi.org/10.1038/nature06174
- Stetler-Stevenson WG, Aznavoorian S, Liotta LA. Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol 1993;9:541-73. https://doi.org/10.1146/annurev.cb.09.110193.002545
- Weiss L. Metastatic inefficiency. Adv Cancer Res 1990;54:159-211. https://doi.org/10.1016/S0065-230X(08)60811-8
- Asiedu MK, Ingle JN, Behrens MD, Radisky DC, Knutson KL. TGF-beta/TNF(alpha)-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype. Cancer Res 2011;71(13):4707-19. https://doi.org/10.1158/0008-5472.CAN-10-4554
- Fernando RI, Castillo MD, Litzinger M, Hamilton DH, Palena C. IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells. Cancer Res 2011;71(15):5296-306. https://doi.org/10.1158/0008-5472.CAN-11-0156
- Yadav A, Kumar B, Datta J, Teknos TN, Kumar P. IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAKSTAT3-SNAIL signaling pathway. Mol Cancer Res 2011;9(12):1658-67. https://doi.org/10.1158/1541-7786.MCR-11-0271
- Massague J, Blain SW, Lo RS. TGF-beta signaling in growth control, cancer, and heritable disorders. Cell 2000;103(2):295-309. https://doi.org/10.1016/S0092-8674(00)00121-5
- FOXM1 confers to epithelial-mesenchymal transition, stemness and chemoresistance in epithelial ovarian carcinoma cells. Oncotarget 2014;6.
- Sehgal I, Thompson TC. Novel regulation of type IV collagenase (matrix metalloproteinase-9 and -2) activities by transforming growth factor-beta1 in human prostate cancer cell lines. Mol Biol Cell 1999;10(2):407-16. https://doi.org/10.1091/mbc.10.2.407
- Hedges JC, Dechert MA, Yamboliev IA, Martin JL, Hickey E, Weber LA, Gerthoffer WT. A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration. J Biol Chem 1999;274(34):24211-9. https://doi.org/10.1074/jbc.274.34.24211
- Liang LD, He T, Du TW, Fan YG, Chen DS, Wang Y. GinsenosideRg5 induces apoptosis and DNA damage in human cervical cancer cells. Mol Med Rep 2015;11(2):940-6. https://doi.org/10.3892/mmr.2014.2821
- Yu Q, Zeng KW, Ma XL, Jiang Y, Tu PF, Wang XM. Ginsenoside Rk1 suppresses pro-inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells by inhibiting the Jak2/Stat3 pathway. Chin J Nat Med 2017;15(10):751-7.
- He X, Ota T, Liu P, Su C, Chien J, Shridhar V. Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells. Cancer Res 2010;70(8):3109-18. https://doi.org/10.1158/0008-5472.CAN-09-3557
- Zhu J, Wang S, Chen Y, Li X, Jiang Y, Yang X, Li Y, Wang X, Meng Y, Zhu M, et al. miR-19 targeting of GSK3beta mediates sulforaphane suppression of lung cancer stem cells. J Nutr Biochem 2017;44:80-91. https://doi.org/10.1016/j.jnutbio.2017.02.020
- Wu YC, Tang SJ, Sun GH, Sun KH. CXCR7 mediates TGF-beta1-promoted EMT and tumor-initiating features in lung cancer. Oncogene 2016;35(16):2123-32. https://doi.org/10.1038/onc.2015.274
- Ko H, So Y, Jeon H, Jeong MH, Choi HK, Ryu SH, Lee SW, Yoon HG, Choi KC. TGF-beta1-induced epithelial-mesenchymal transition and acetylation of Smad2 and Smad3 are negatively regulated by EGCG in human A549 lung cancer cells. Cancer Lett 2013;335(1):205-13. https://doi.org/10.1016/j.canlet.2013.02.018
- Ko H, Jeon H, Lee D, Choi HK, Kang KS, Choi KC. Sanguiin H6 suppresses TGF-beta induction of the epithelial-mesenchymal transition and inhibits migration and invasion in A549 lung cancer. Bioorg Med Chem Lett 2015;25(23):5508-13. https://doi.org/10.1016/j.bmcl.2015.10.067
- Ko H. Geraniin inhibits TGF-beta1-induced epithelial-mesenchymal transition and suppresses A549 lung cancer migration, invasion and anoikis resistance. Bioorg Med Chem Lett 2015;25(17):3529-34. https://doi.org/10.1016/j.bmcl.2015.06.093
- Pang L, Li Q, Wei C, Zou H, Li S, Cao W, He J, Zhou Y, Ju X, Lan J, et al. TGF-beta1/Smad signaling pathway regulates epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma: in vitro and clinical analyses of cell lines and nomadic Kazakh patients from northwest Xinjiang, China. PLoS One 2014;9(12):e112300. https://doi.org/10.1371/journal.pone.0112300
- Feng H, Lu JJ, Wang Y, Pei L, Chen X. Osthole inhibited TGF beta-induced epithelial-mesenchymal transition (EMT) by suppressing NF-kappaB mediated Snail activation in lung cancer A549 cells. Cell Adh Migr 2017;11(5-6):464-75. https://doi.org/10.1080/19336918.2016.1259058
- Xie L, Law BK, Chytil AM, Brown KA, Aakre ME, Moses HL. Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro. Neoplasia 2004;6(5):603-10. https://doi.org/10.1593/neo.04241
- Liang Y, Ye J, Jiao J, Zhang J, Lu Y, Zhang L, Wan D, Duan L, Wu Y, Zhang B. Down-regulation of miR-125a-5p is associated with salivary adenoid cystic carcinoma progression via targeting p38/JNK/ERK signal pathway. Am J Transl Res 2017;9(3):1101-13.
- Mochizuki M, Yoo YC, Matsuzawa K, Sato K, Saiki I, Tono-oka S, Samukawa K, Azuma I. Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng. Biol Pharm Bull 1995;18:1197-202. https://doi.org/10.1248/bpb.18.1197
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