Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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The Prognosis of Glyphosate herbicide intoxicated patients according to their salt types

글라이포세이트 중독 환자에서 포함된 염의 종류에 따른 예후의 차이

  • Jeong, Min Gyu (Department of Emergency Medicine, Samsung Changwon Hospital, Sungkyunkwan University, School of Medicine) ;
  • Keum, Kyoung Tak (Department of Emergency Medicine, Samsung Changwon Hospital, Sungkyunkwan University, School of Medicine) ;
  • Ahn, Seongjun (Department of Emergency Medicine, Samsung Changwon Hospital, Sungkyunkwan University, School of Medicine) ;
  • Kim, Yong Hwan (Department of Emergency Medicine, Samsung Changwon Hospital, Sungkyunkwan University, School of Medicine) ;
  • Lee, Jun Ho (Department of Emergency Medicine, Samsung Changwon Hospital, Sungkyunkwan University, School of Medicine) ;
  • Cho, Kwang Won (Department of Emergency Medicine, Samsung Changwon Hospital, Sungkyunkwan University, School of Medicine) ;
  • Hwang, Seong Youn (Department of Emergency Medicine, Samsung Changwon Hospital, Sungkyunkwan University, School of Medicine) ;
  • Lee, Dong Woo (Department of Emergency Medicine, Samsung Changwon Hospital, Sungkyunkwan University, School of Medicine)
  • 정민규 (성균관대학교 의과대학 삼성창원병원 응급의학과) ;
  • 금경탁 (성균관대학교 의과대학 삼성창원병원 응급의학과) ;
  • 안성준 (성균관대학교 의과대학 삼성창원병원 응급의학과) ;
  • 김용환 (성균관대학교 의과대학 삼성창원병원 응급의학과) ;
  • 이준호 (성균관대학교 의과대학 삼성창원병원 응급의학과) ;
  • 조광원 (성균관대학교 의과대학 삼성창원병원 응급의학과) ;
  • 황성연 (성균관대학교 의과대학 삼성창원병원 응급의학과) ;
  • 이동우 (성균관대학교 의과대학 삼성창원병원 응급의학과)
  • Received : 2021.06.21
  • Accepted : 2021.08.17
  • Published : 2021.12.31
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Abstract

Purpose: Glyphosate herbicide (GH) is a widely used herbicide and has been associated with significant mortality as poisoned cases increases. One of the reasons for high toxicity is thought to be toxic effect of its ingredient with glyphosate. This study was designed to determine differences in the clinical course with the salt-type contained in GH. Methods: This was a retrospective study conducted at a single hospital between January 2013 and December 2017. We enrolled GH-poisoned patients visited the emergency department. According to salt-type, patients were divided into 4 groups: isopropylamine (IPA), ammonium (Am), potassium (Po), and mixed salts (Mi) groups. The demographics, laboratory variables, complications, and their mortality were analyzed to determine clinical differences associated with each salt-type. Addtionally, we subdivided patients into survivor and non-survivor groups for investigating predictive factors for the mortality. Results: Total of 348 GH-poisoned patients were divided as follows: IPA 248, Am 41, Po 10, and Mi 49 patients. There was no difference in demographic or underlying disease history, but systolic blood pressure (SBP) was low in Po group. The ratio of intentional ingestion was higher in Po and Mi groups. Metabolic acidosis and relatively high lactate level were presented in Po group. As the primary outcome, the mortality rates were as follows: IPA, 26 (10.5%); Am, 2 (4.9%); Po, 1 (10%); and Mi, 1 (2%). There was no statistically significant difference in the mortality and the incidence of complications. Additionally, age, low SBP, low pH, corrected QT (QTc) prolongation, and respiratory failure requiring mechanical ventilation were analyzed as independent predictors for mortality in a regression analysis. Conclusion: There was no statistical difference in their complications and the mortality across the GH-salt groups in this study.

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References

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