Pediatric Gastroenterology, Hepatology & Nutrition

  • 제24권2호
  • /
  • Pages.207-217
  • /
  • 2021
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  • 2234-8646(pISSN)
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  • 2234-8840(eISSN)
대한소아소화기영양학회 (The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition)
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Seasonal Changes in Vitamin D Levels of Healthy Children in Mid-Latitude, Asian Urban Area

  • Won, Jong Woo (Department of Pediatrics, Korea University Medical Center) ;
  • Jung, Seong Kwan (Department of Pediatrics, Woorisoa Children's Hospital) ;
  • Jung, In Ah (Department of Pediatrics, Woorisoa Children's Hospital) ;
  • Lee, Yoon (Department of Pediatrics, Korea University Medical Center)
  • 투고 : 2020.08.24
  • 심사 : 2020.10.25
  • 발행 : 2021.03.15
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초록

Purpose: This study aimed to investigate the seasonal changes in vitamin D levels in a healthy pediatric population living in mid-latitude East Asian urban areas. Methods: A pediatric population was selected from single secondary hospital visitors. Clinical data and serum vitamin D levels were collected retrospectively. Statistical analyses were performed based on the month of the blood sampling date, subject age, and vitamin D supplementation history. The data were categorized into three subgroups based on serum vitamin D levels-adequate (≥30 ng/mL), insufficient (20-29 ng/mL), and deficient (<20 ng/mL). Results: Of the 481 patients, 172 had vitamin D supplementation history. More than 70% of the total study population had inadequate vitamin D levels (<30 ng/mL). The non-supplemented group and the supplemented group showed significantly uneven monthly distribution of the adequate, insufficient, and deficient subgroups. Only the non-supplemented group showed significantly different average vitamin D levels in the summer months compared to the winter months. In the non-supplemented group, vitamin D levels were the lowest in March, the highest in August and September. Significant relevance was noted between vitamin D supplementation status and vitamin D serum level in February and March. There was no significant difference between different age groups in terms of the distribution of vitamin D levels. Conclusion: Currently-widespread vitamin D replacement methods seem to have some effect on increasing the overall serum vitamin D levels, specifically during late winter when natural serum vitamin D levels plunge. However, they are unable to fully compensate the seasonal fluctuation.

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참고문헌

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피인용 문헌

  1. Vitamin D and Hashimoto’s Thyroiditis: Observations from CROHT Biobank vol.13, pp.8, 2021, https://doi.org/10.3390/nu13082793