Pediatric Infection and Vaccine

The Korean Society of Pediatric Infectious Diseases (대한소아감염학회)
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Severe Anemia Caused by Parvovirus B19 Infection in Two Pediatric Kidney Transplantation Recipients

소아 신장이식 환자에서 발생한 파르보바이러스 B19에 의한 심한 빈혈에 대한 증례 보고 및 문헌 고찰

  • Kim, Kyung-Ran (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Park, Hwanhee (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Doo Ri (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Cho, Heeyeon (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Sanghoon (Division of Pediatric Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Suk-Koo (Division of Pediatric Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Yae-Jean (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 김경란 (성균관대학교 의과대학, 삼성서울병원 소아청소년과) ;
  • 박환희 (성균관대학교 의과대학, 삼성서울병원 소아청소년과) ;
  • 김두리 (성균관대학교 의과대학, 삼성서울병원 소아청소년과) ;
  • 조희연 (성균관대학교 의과대학, 삼성서울병원 소아청소년과) ;
  • 이상훈 (성균관대학교 의과대학, 삼성서울병원 소아외과) ;
  • 이석구 (성균관대학교 의과대학, 삼성서울병원 소아외과) ;
  • 김예진 (성균관대학교 의과대학, 삼성서울병원 소아청소년과)
  • Received : 2021.10.25
  • Accepted : 2022.01.03
  • Published : 2021.12.25
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Abstract

Anemia commonly occurs in kidney transplantation (KT) recipients. Many factors such as viral infection, bleeding, erythropoietin deficiency, and immunosuppressants are the causes of chronic anemia in KT recipients. We report 2 cases who developed severe anemia caused by parvovirus B19 infection and were successfully treated with intravenous immunoglobulin in pediatric KT recipients.

신장이식 환자에서 만성 빈혈은 치료 과정 중 발생하는 합병증으로 바이러스 감염, 적혈구형성호르몬결핍, 출혈, 면역억제제의 부작용 등과 관련이 있다. 신장이식 환자에서 파르보바이러스 B19에 의한 빈혈은 초감염 혹은 기존 감염의 재활성화로 발생할 수 있으며, 아직 이에 대한 치료법은 정립이 되어 있지 않다. 특히, 소아청소년 신장이식 환자에 대한 보고나 자료는 더욱 드물다. 저자들은 소아청소년 신장이식 환자에서 발생한 심각한 빈혈을 파르보바이러스 B19 PCR 검사법으로 진단하고, 정맥내글로불린으로 재발 없이 성공적으로 치료한 두 증례와 문헌 고찰을 보고하는 바이다.

Keywords

References

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