Molecules and Cells

  • 제44권2호
  • /
  • Pages.68-78
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  • 2021
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
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Cucurbitacin B Suppresses Hyperglycemia Associated with a High Sugar Diet and Promotes Sleep in Drosophila melanogaster

  • Sang, Jiun (Department of Bio and Fermentation Convergence Technology, Kookmin University) ;
  • Dhakal, Subash (Department of Bio and Fermentation Convergence Technology, Kookmin University) ;
  • Lee, Youngseok (Department of Bio and Fermentation Convergence Technology, Kookmin University)
  • 투고 : 2020.12.09
  • 심사 : 2021.01.19
  • 발행 : 2021.02.28
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초록

Secondary metabolites enable plants to protect themselves from herbivorous insects. Among these, cucurbitacin B (cuc-B) is a bitter-tasting compound with promising pharmacological potential. Dietary exposure to cuc-B lowered the hemolymph glucose levels of Drosophila melanogaster fed with a high carbohydrate diet, which is homologous to high blood glucose in humans, and its effect was comparable to that of metformin, a well-known glucose-lowering drug. Furthermore, cuc-B reduced tissue sugar levels and glycogen levels, as well as triacylglycerol levels. Our results thus highlight the potential applicability of this compound to treat chronic metabolic diseases such as diabetes and obesity. Additionally, we analyzed sleep quality and taste-associative memory enhancement after cuc-B and metformin treatment. Both supplements increased nighttime bout length and metformin increased memory consolidation. Therefore, discarded shell of Cucurbitaceae could be processed into health supplements.

키워드

과제정보

This work was supported by grants to Y.L. from the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1A2B6004202) and Korea Environmental Industry and Technology Institute (KEITI) grant funded by the Ministry of Environment of Korea. S.D. was supported by the Global Scholarship Program for Foreign Graduate Students at Kookmin University in Korea.

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