Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Comparative Proteomic Profile of Canine Uterus with Pyometra

  • Ahn, Soomin (College of Veterinary Medicine, Gyeongsang National University) ;
  • Saralamma, Venu Venkatarame Gowda (Research Institute of Life science and College of Veterinary Medicine, Gyeongsang National University) ;
  • Vetrivel, Preethi (Research Institute of Life science and College of Veterinary Medicine, Gyeongsang National University) ;
  • Han, Hyun-Jung (Department of Veterinary Emergency and Critical Care Medicine, Konkuk Veterinary Medical Teaching Hospital, Konkuk University) ;
  • Park, Jinho (College of Veterinary Medicine, Jeonbuk National University) ;
  • Jung, Dong-In (College of Veterinary Medicine, Gyeongsang National University) ;
  • Kim, Gon Sup (Research Institute of Life science and College of Veterinary Medicine, Gyeongsang National University) ;
  • Yu, DoHyeon (College of Veterinary Medicine, Gyeongsang National University)
  • Received : 2020.09.23
  • Accepted : 2021.01.20
  • Published : 2021.02.28
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Abstract

Pyometra, a common disorder in intact bitches, can lead to canine sepsis. Identification of biomarkers for sources of infection in the uterus using two-dimensional electrophoresis (2-DE)-mass spectrometry (MS) analysis may enable the discovery of novel diagnostic markers of sepsis. Toward this end, surgically resected uterus samples from four bitches (three pyometra and one healthy) were randomly selected for 2-DE-MS, which identified 32 differentially expressed proteins, including seven inflammatory proteins, five non-inflammatory proteins, and 20 functionally unknown proteins. Despite the limited information on canine uterus proteomics, we suggest the potential use of differentially expressed uterus proteins as candidate biomarkers to discover targets to attenuate inflammation in pyometra. Further identification of the functionally unknown proteins is warranted.

Keywords

References

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