한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제38권1호
  • /
  • Pages.7-15
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  • 2021
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
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Safety Evaluation of Kyungokgo-gamibang Administration Based on Hematological, Biochemical, Protein, and Lipid Profiles in Dogs

  • Song, Doo-won (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Lee, Ga-won (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Ro, Woong-bin (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Heyong-seok (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kang, Hyun-min (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Jong-won (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Park, Soo-bin (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Moon, Yang-seon (Scholl of Korean Medicine, Dongshin University) ;
  • Na, Chang-su (Nawoori (Ltd)) ;
  • Park, Hee-myung (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • 투고 : 2020.12.04
  • 심사 : 2021.01.14
  • 발행 : 2021.02.28
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초록

Kyungokgo-gamibang, Kyungokgo with Iksuyongjingo and Sparassis crispa, is a traditional Korean medicine used for restorative effects. This study aimed to evaluate the safety of Kyungokgo-gamibang in healthy beagle dogs. In the single-dose oral toxicity study, three beagle dogs were orally administered 2,000, 1,000, and 500 mg/kg of Kyungokgo-gamibang and were observed for 14 days. In the repeated-dose oral toxicity study, nine healthy dogs were orally administered 0.2g/kg of Kyungokgo-gamibang (n = 3, low-dose group), 1 g/kg of Kyungokgo-gamibang (n = 3, high-dose group), or normal saline (n = 3, control group) twice a day for 8 weeks. The hematological, serum biochemical, urine, protein, and lipid profiles were evaluated to investigate the adverse effects of the Kyungokgo-gamibang. During the study period, the dogs demonstrated no clinical signs and the hematological, serum biochemical, urine, protein, and lipid analyses revealed unremarkable findings. The study results suggest that Kyungokgo-gamibang can be safely administered to dogs without any adverse effects.

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