The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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Antinociceptive effects of oleuropein in experimental models of neuropathic pain in male rats

  • Chen, Huayong (Department of Anesthesiology, Yidu Central Hospital of Weifang) ;
  • Ma, Dandan (Department of Anesthesiology, Yidu Central Hospital of Weifang) ;
  • Zhang, Huapeng (Department of Anesthesiology, Yidu Central Hospital of Weifang) ;
  • Tang, Yanhong (Department of Anesthesiology, Hospital T.C.M Affiliated to Southwest Medical University) ;
  • Wang, Jun (Orbital Disease and Ophthalmoplasty, Department of Ophthalmological Hospital, The Second Hospital of Jilin) ;
  • Li, Renhu (Department of Anesthesiology, The Lu'an Affiliated Hospital of Anhui Medical University) ;
  • Wen, Wen (Department of Anesthesiology, Affiliated Hospital of Guilin Medical University) ;
  • Zhang, Yi (Department of Anesthesiology, Tongji Hospital Affiliated Tongji Medical College, Huazhong Science and Technology University)
  • Received : 2020.09.24
  • Accepted : 2020.11.17
  • Published : 2021.01.01
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Abstract

Background: The present investigation explored the therapeutic actions of oleuropein along with the possible signaling pathway involved in attenuating neuropathic pain in chronic constriction injury (CCI) and vincristine-induced neuropathic pain in male rats. Methods: Four loose ligatures were placed around the sciatic nerve to induce CCI, and vincristine (50 ㎍/kg) was injected for 10 days to develop neuropathic pain. The development of cold allodynia, mechanical allodynia, and mechanical hyperalgesia was assessed using different pain-related behavioral tests. The levels of H2S, cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), orexin, and nuclear factor erythroid-2-related factor 2 (Nrf2) were measured in the sciatic nerve. Results: Treatment with oleuropein for 14 days led to significant amelioration of behavioral manifestations of neuropathic pain in two pain models. Moreover, oleuropein restored both CCI and vincristine-induced decreases in H2S, CSE, CBS, orexin, and Nrf2 levels. Co-administration of suvorexant, an orexin receptor antagonist, significantly counteracted the pain-attenuating actions of oleuropein and Nrf2 levels without modulating H2S, CSE and CBS. Conclusions: Oleuropein has therapeutic potential to attenuate the pain manifestations in CCI and vincristine-induced neuropathic pain, possibly by restoring the CSE, CBS, and H2S, which may subsequently increase the expression of orexin and Nrf2 to ameliorate behavioral manifestations of pain.

Keywords

References

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