Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Primary diffuse hepatocellular carcinoma in a captive polar bear (Ursus maritimus)

  • Krisdianti, Krisdianti (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Kim, Taeyeon (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Aufa, Sulhi (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Lee, Sangjoon (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Ahn, Sangjin (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Cho, Ho-Seong (College of Veterinary Medicine and Bio-Safety Research Institute, Jeonbuk National University) ;
  • Oh, Yeonsu (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University)
  • Received : 2021.11.29
  • Accepted : 2021.12.21
  • Published : 2021.12.30
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Abstract

A captive male polar bear (Ursus maritimus) was found dead after a long-term anorexia at a Park Zoo in Republic of Korea. At necropsy, the liver lesion was prominent with hepatomegaly carrying a big mass and numerous small nodules in various sizes. The cut surface of the nodules was creamy white, firm, and solid with umbilicated appearance. Histologically, there was proliferation of hepatocellular neoplastic cells arranged in glandular-like (pseudoglandular) pattern and complete loss of hepatocellular arrangement. The immunoreactivity for neoplastic hepatocyte antigens was positive for hepatocyte paraffin 1, and negative for vimentin, cytokeratin 7 and 19, and carcinoembryonic antigen. Based on those diagnostic features, the neoplasia was diagnosed as hepatocellular carcinoma. To the author's knowledge, this is the first case report of hepatocellular carcinoma in the captive polar bear in Republic of Korea.

Keywords

Acknowledgement

This work was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through Livestock Industrialization Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA)(No. 321081-4).

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