Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Xanthone and Flavonoid Derivatives from the Leaves of Maclura tricuspidata with Antioxidant and Anti-tyrosinase Activity

  • Jo, Yang Hee (College of Pharmacy, Chungbuk National University) ;
  • Lee, Solip (College of Pharmacy, Chungbuk National University) ;
  • Ryu, Se Hwan (College of Pharmacy, Chungbuk National University) ;
  • Yeon, Sang Won (College of Pharmacy, Chungbuk National University) ;
  • Turk, Ayman (College of Pharmacy, Chungbuk National University) ;
  • Hwang, Bang Yeon (College of Pharmacy, Chungbuk National University) ;
  • Lee, Mi Kyeong (College of Pharmacy, Chungbuk National University)
  • Received : 2021.11.23
  • Accepted : 2021.12.07
  • Published : 2021.12.31
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Abstract

Masclura tricuspidata, also called as Cudrania tricuspidata, is one of the most common Moraceae family plants in East Asia. Its trivial name follows mulberry due to the similar morphology. Investigation of the bioactive constituents of M. tricuspidata leaves yielded a new xanthone derivative along with twenty known compounds through various chromatographic techniques. A new compound was defined as mascluraxanthone (3), a prenylated xanthone glucoside on the basis of 1D and 2D NMR and MS data. Twenty known compounds were identified as four xanthone derivatives (1-2 and 4-5), two flavans (6-7), six flavanol derivatives (8-13), a flavonone (14) and seven flavonol derivatives (15-21). Among the isolated compounds, flavanol and flavonoid derivatives with 3',4'-OH groups showed antioxidant and anti-tyrosinase activities. Conclusively, the leaves of M. tricuspidata are rich in aromatic compounds including xanthones and flavonoids. In addition, these constituents showed antioxidant and anti-tyrosinase potentials, which might be useful for oxidative stress related diseases.

Keywords

Acknowledgement

This work was financially supported by the Research Year of Chungbuk National University in 2020

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