Natural Product Sciences

  • 제27권4호
  • /
  • Pages.228-233
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  • 2021
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
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Chemical Constituents from Agrimonia pilosa with Inhibitory Activity against Interleukin 1β Production via NLRP3 and NLRC4 Inflammasomes

  • Nhoek, Piseth (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Chae, Hee-Sung (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • An, Chae-Yeong (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Pel, Pisey (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Kim, Young-Mi (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Chin, Young-Won (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
  • 투고 : 2021.11.09
  • 심사 : 2021.12.07
  • 발행 : 2021.12.31
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초록

Bioactivity-guided fractionation by preliminary screening using interleukin-1β production in lipopolysaccharides (LPS)-induced J774A.1 cell line led to the isolation of fourteen structures including chromone, isocoumarins, flavanoids, and triterpenes from the aerial part of Agrimonia pilosa Ledeb. All structures were determined by measuring their spectroscopic data and comparing their spectroscopic data with the literatures. All the isolates were tested for their inhibitory activities against interleukin-1β production in LPS-induced J774A.1 cell. Of the tested compounds, (S)-(+)-5,7-dihydroxy-2-(1-methylpropyl)chromone (1), agrimonolide-6-O-β-D-glucopyranoside (5), agrimonolide-6-O-α-L-arabinofuranosyl-(1→6)-β-D-glucopyranoside (6), and catechin (10) were found to be active. Furthermore, compound 1 suppressed the protein expressions of NLRP3 and NLRC4 in murine macrophage.

키워드

과제정보

This study was supported by a grant (NRF-2019R1A2C2009053) from the National Research Foundation of Korea (NRF), funded by the Korean government (MSIT).

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