DOI QR코드

DOI QR Code

소아암의 한의치료 임상 실제 - 중의 증례연구를 중심으로

Traditional Chinese Medicine Treatment for Childhood Cancer - Review of Case Studies

  • 황윤경 (부산대학교 한의학전문대학원 한의학과) ;
  • 김윤환 (부산대학교 한의학전문대학원 한의학과) ;
  • 윤영주 (부산대학교 한의학전문대학원 동서협진의학)
  • Hwang, Yungyeong (Department of Korean Medicine, School of Korean Medicine, Pusan National University) ;
  • Kim, Younhwan (Department of Korean Medicine, School of Korean Medicine, Pusan National University) ;
  • Yun, Youngju (Department of Integrative Medicine, School of Korean Medicine, Pusan National University)
  • 투고 : 2021.09.23
  • 심사 : 2021.12.09
  • 발행 : 2021.12.31

초록

Objective : To investigate specific prescriptions, herbal medicines and treatment strategy, this study systematically reviewed case studies on traditional Chinese medicine (TCM) treatment for childhood cancer. Method : Literature searches were performed on database of China National Knowledge Infrastructure (CNKI). Studies published before December 2020 were categorized and analyzed according to the treatment strategy and we also investigated Chinese herbs used in the prescriptions. Results : Twenty-five studies including 17 case series and 8 single case reports were included in our review. Of the total 439 patients, 379 (85.7%) had leukemia and other myeloplastic disease. Conventional western medicine (CWM) treatment was also used with TCM based on the syndrome identification. Most studies reported favorable effect of combination treatment with CWM and TCM. Among 266 herbs in the studies, reinforcing herbs were more frequently used than anti-cancer herbs. Conclusion : Traditional herbal treatment for childhood cancer should be performed considering the syndrome identification as well as stage of CWM. Reinforcing herbs should be more focused because of the fragility and growth of the childhood.

키워드

과제정보

이 과제는 부산대학교 기본연구 지원사업(2년)에 의하여 연구되었음

참고문헌

  1. Statistics Korea. Causes of death Statistics in 2019. Available from : URL : http://kostat.go.kr/portal/korea/kor_nw/1/6/2/index.board?bmode=read&bSeq=&aSeq=385219&pageNo=1&rowNum=10&navCount=10&currPg=&searchInfo=&sTarget=title&sTxt=
  2. Steliarova-Foucher E, Colombet M, Ries LAG, Moreno F, DolyaA, Bray F, et al. International incidence of childhood cancer, 2001-10: apopulation-based registry study. Lancet Oncol. 2017;18(6):719-31. https://doi.org/10.1016/S1470-2045(17)30186-9
  3. Statistics Korea. Number of childhood cancer/sex/cancer incidence, relative frequency, premature incidence, and age standardization rate according to international pediatric cancer classification standards. Available from : URL : https://kosis.kr/statHtml/statHtml.do?orgId=117&tblId=DT_117N_A11105
  4. Number and incidence of cancer by 61 cancer species/sex/age (5 years old). Available from : URL : https://kosis.kr/statHtml/statHtml.do?orgId=117&tblId=DT_117N_A0024&vw_cd=&list_id=&seqNo=&lang_mode=ko&language=kor&obj_var_id=&itm_id=&conn_path=I2
  5. Park JG, Bang YJ, Ha SH. Oncology. Revised edition. Iljogak. 2012 : 1
  6. Diorio C, Lam CG, Ladas EJ, Njuguna F, Afungchwi GM, TarominaK, et al. Global Use of Traditional and Complementary Medicine in Childhood Cancer: A Systematic Review. J Glob Oncol. 2017;3(6):791-800 https://doi.org/10.1200/jgo.2016.005587
  7. Bishop FL, Prescott P, Chan YK, Saville J, von Elm E, Lewith GT. Prevalence of complementary medicine use in pediatric cancer: a systematic review. Pediatrics. 2010;125(4):768-76. https://doi.org/10.1542/peds.2009-1775
  8. Choi YJ, Lee JS, Cho SH. Use of Korean Medicine among Cancer Patients. The Journal of Korean Medicine. 2012;33(3):46-53.
  9. Ha KS, Song IS, Shin JN, Lee JL. The Clinical Study on a Case of Acute Myelogenous Leukemia. J Korean Oriental Pediatrics. 2004;18(2):49-59.
  10. Park JW, Kim KS, Jung HS, Choi WC, Yoon SW. The Study on the Safety and Case Series of the Acute Lymphocytic Leukemia using Rhus Verniciflua Stokes Extract (Nexia). J of Kor. Oriental Oncology. 2006;11(1):1-21.
  11. Park ES, Han BY, Kim MS, Shin HY, Ahn HS. Possibility of alternative medicine in the field of pediatric hematology-oncolgy : analysis of 7 cases of unexpected outcome by modern medicine. Clinical Pediatric Hematology-Oncology. 2011;18(2):126-35.
  12. Park BK, Lee JH, Cho CK, Shin HK, Eom SK, Yoo HS. Systemic review of clinical studies about oriental medical treatment of cancer in Korea. Korean J. Oriental.Int. Med. 2008; 29(4):1061-1074.
  13. Yang G, Li X, Li X, Wang L, Li J, Song X, Chen J, Guo Y, Sun X, Wang S, Zhang Z, Zhou X, Liu J. Traditional chinese medicine in cancer care: A review of case series published in the chinese literature. Evidence-Based Complementary and Alternative Medicine. 2012; 2012.
  14. Kim YH, Kim HS, Oh JM, Lee HY, Min YR, Yun YJ. Traditional Asian Medicine Treatment for Childhood Cancer - Review of Controlled Clinical Studies. Journal of Society of Preventive Korean Medicine [Internet]. 2020 Aug; 24(2):17-30. Available from: https://doi.org/10.25153/SPKOM.2020.24.2.002
  15. Cheng Z, Wu Y. Treatment of 25 cases of childhood acute lymphocytic leukemia with traditional Chinese medicine combined with Western medicine chemotherapy. Sichuan Journal of Traditional Chinese Medicine. 2004 (11):68-9.
  16. Feng CL, Guo YZ, Li P. Experience of traditional Chinese medicine supplementary treatment during chemotherapy for childhood leukemia. Chinese Journal of Primary Medicine Pharmacy. 2002(02):84-5.
  17. Jiang RA. Experience of traditional Chinese medicine combined with chemotherapy in the treatment of children with acute leukemia. Suzhou University Journal of Medical Science. 1995(03):550.
  18. Leukemia group of The Children's Hospital of Zhejiang University Shcool of Medicine. Comprehensive induction therapy of traditional Chinese and Western medicine for acute myeloid leukemia in children. Journal of Chinese Oncology. 1976(03):39-45.
  19. Cai ZX. Clinical Research of Treating Side Effects of Chemotherapy to Neuroblastoma Based on Jueyin and Zhongqi. [master's thesis]: Southern Medical University; 2016.
  20. Hwang JZ. Analysis of 103 cases of acute leukemia in children treated with integrated traditional Chinese and Western Medicine. Fujian Medical Journal. 1990(03):20.
  21. Wen JZ. Treatment of 44 cases of acute lymphoblastic leukemia in children with integrated traditional Chinese and Western Medicine. Journal of Zhejiang College of Traditional Chinese Medicine. 1989(04):26-7.
  22. Wang Y, You CX. Application of traditional Chinese medicine (TCM) nursing in chemotherapy for children with leukemia. China Modern Medicine. 2013;20(20):162-3.
  23. Pang XH. Summary of 11 cases of malignant lymphoma in children treated with integrated traditional Chinese and Western Medicine. Beijing Journal of Traditional Chinese Medicine. 2006(05):289-91.
  24. Zhou JY, Du FG. Two cases of meningeal leukemia in children treated with integrated traditional Chinese and Western Medicine (Abstract). Shenyang Army Medical. 1998(03):209.
  25. Wen ZY, Song ZM, Wu DZ, Yu ZL. Discussion on the scheme of integrated traditional Chinese and Western medicine in the treatment of acute leukemia in children (clinical analysis of 30 cases). Shandong Journal of Traditional Chinese Medicine. 1983(01):19-21+45.
  26. Hemopathy research team of Qinghai TCM Hospital. Clinical experience of integrated traditional Chinese and Western medicine in the treatment of 7 cases of children with acute leukemia. Qinghai Medical Journal. 1976(05):30-4.
  27. Wen LT. Summarize Experience about Professor Lyu Ying Based on the "Qi Monism" Treatment of Pediatric Tumors from Zhongqi [master's thesis]: Southern Medical University;2018.
  28. Feng KJ. Summarize Experience about Professor Lyu Ying Based on the "Qi Monism" Treatment of Children with Cancer [master's thesis]: Southern Medical University; 2017.
  29. Chen KY, Li N, Zhang Q. Yu Rencun's experience in treating pediatric hepatoblastoma from spleen and kidney. Chinese Journal of Information on Traditional Chinese Medicine. 2016;23(10):110-2.
  30. Jia L, Chen RM. Veteran TCM Doctor CHEN Wenxuan's Experience of Treating Children with Leukemia. Western Journal of Traditional Chinese Medicine. 2013;26(08):34-7.
  31. Yang ML, Ding JH. Treatment of 4 cases of pediatric tumors with traditional Chinese Medicine. Shanghai Journal of Traditional Chinese Medicine. 1988(11):12-3.
  32. Wen LT, Feng KJ, Liu LF, Liu ZR, Li AW, Lyu Y. Brief Discussion about LYU Ying Applying "Yangming-downward Movement" Theory to Treat Pediatric Tumors. Liaoning Journal of Traditional Chinese Medicine. 2017; 44(11):2288-91.
  33. Zhou NY, Li YC, Lyu Y. Exploration and Treatment of Pediatric Tumors from Restoring "Yangming-downward Movement" Which based on the Qi-monism. Guangming Journal of Chinese Medicine. 2015;30(10):2089-91.
  34. Chen J, Zhou QX, Cheng Q, Yang W, Zhang Y. Clinical analysis of a case of Papillary thyroid carcinoma of thyroid in children. Hubei Journal of Traditional Chinese Medicine. 2011;33(08):44-5.
  35. Xu C, Zhang DD. Prevention and treatment of liver dysfunction caused by chemotherapy with traditional Chinese medicine in pediatric leukemia. Pediatric branch of Chinese society of traditional Chinese Medicine conference; 2010; Shanghai, China
  36. Liao XL, Xu C, Zhang DD. Traditional Chinese medicine treatment of thrombocytopenia after chemotherapy in children with leukemia. Pediatric branch of Chinese society of traditional Chinese Medicine conference; 2010; Shanghai, China
  37. Hwang B. The Research on Classic Formula of Huang Huang and the Analysic on Cliniacl Cases from 2004 to 2007 [doctoral thesis]: Nanjing university of Chinese medicine; 2008.
  38. Yang QJ, Sun GH. Modified Guizhi Decoction in the treatment of fever after chemotherapy in children with tumor. Hubei Journal of Traditional Chinese Medicine. 1999(11):519. https://doi.org/10.3969/j.issn.1000-0704.1999.11.038
  39. Zhu YB, An YX. A case of children with acute myeloid leukemia survived for four and a half years treated with integrated traditional Chinese and Western Medicine. Journal of Medical Science Yanbian University. 1979(01):105-6.
  40. Guideline for diagnosis and treatment of Tumor in TCM. China: China Traditional Chinese Medicine Publishing House; 2008
  41. Korean Association of Traditional Oncology textbook compilation committee. Integrate Oncology of Korean Medicine. Korea: Gunja Publishing Company; 2013
  42. Liu ZM, Shi X. Analysis of TCM syndrome differentiation characteristics of 220 children with solid tumor during chemotherapy. Beijing Journal of Traditional Chinese Medicine. 2011;30(01):10-1.
  43. Seok HP. Access to the treatment of childhood leukaemia through the integration of traditional Chinese and western medicine. J Korean Oriental Pediatrics. 2001;15(1):71-5.
  44. Clinical Practice Guidelines Of Chinese Medicine In Oncology. People's Medical Publishing House; 2016.
  45. Kim JE, Jang JW, Park BC, Kim KB, Cheon JH. Review of Clinical Studies for Herbal Medicine Treatment on Acute Leukemia - Focusing on Studies from the China Academic Journal (CAJ). J Korean Oriental Pediatrics [Internet]. 2021 Feb 28;35(1):48-62. Available from: https://doi.org/10.7778/JPKM.2021.35.1.48
  46. Wang YJ, Liao CC, Chen HJ, Hsieh CL, Li TC. The Effectiveness of Traditional Chinese Medicine in Treating Patients with Leukemia. Evid Based Complement Alternat Med. 2016;2016:8394850.