Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Anti-diabetic effects of aqueous extract of Dendropanax morbifera Lev. leaves in streptozotocin-induced diabetic Sprague-Dawley rats

Streptozotocin으로 유도된 당뇨 랫드에서 황칠나무 잎 열수추출물의 항당뇨 효과

  • Kim, Min-Jae (Graduate School of Public Health, Gyeongsang National University) ;
  • Kang, Ye-Jin (Graduate School of Public Health, Gyeongsang National University) ;
  • Lee, Dong-Eon (Department of Anesthesiology and Pain Medicine, Inje University Busan Paik Hospital) ;
  • Kim, Suk (College of Veterinary Medicine and Institute of Animal Medicine, Gyeongsang National University) ;
  • Lim, Se-Hun (Department of Anesthesiology and Pain Medicine, Inje University Busan Paik Hospital) ;
  • Lee, Hu-Jang (Graduate School of Public Health, Gyeongsang National University)
  • 김민재 (경상국립대학교 보건대학원) ;
  • 강예진 (경상국립대학교 보건대학원) ;
  • 이동언 (인제대학교 부산백병원 마취통증의학교실) ;
  • 김석 (경상국립대학교 수의과대학 및 동물의학연구소) ;
  • 임세훈 (인제대학교 부산백병원 마취통증의학교실) ;
  • 이후장 (경상국립대학교 보건대학원)
  • Received : 2021.07.13
  • Accepted : 2021.10.18
  • Published : 2021.12.31
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Abstract

This study examined the anti-diabetic effects of aqueous extracts of Dendropanax morbifera leaves (DMWEs) in streptozotocin-induced diabetic Sprague-Dawley (SD) rats. Thirty male SD rats (body weight [BW], 250.4 ± 19.7 g) were divided into the following six groups: normal control rats (NC), diabetic control rats (DC), diabetic rats treated with metformin HCl 100 mg/kg BW (DT), diabetic rats treated with DMWEs 50 mg/kg BW (DM-50), diabetic rats treated with DMWEs 100 mg/kg BW (DM-100), and diabetic rats treated with DMWEs 200 mg/kg BW (DM-200). From two weeks of administration of DMWEs, the BW of all groups treated with DMWEs increased significantly compared to DC (p < 0.05). At four weeks after treatment, the blood glucose levels in DT, DM-100, and DM-200 decreased below 200 mg/dL, while the glycated hemoglobin concentrations in all groups administered DMWEs were similar to those of NC and DT. Regarding the blood biochemical parameters, the levels of aspartate transaminase, alanine transaminase, blood urea nitrogen, and creatinine in DM-100 and DM-200 were similar to those in NC and DT. Overall, these results highlight the effectiveness of DM-100 in the treatment of diabetes.

Keywords

References

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