대한한의학방제학회지 (Herbal Formula Science)

  • 제29권4호
  • /
  • Pages.285-295
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  • 2021
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  • 1229-1218(pISSN)
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  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
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Helicobacter pylori Infection에 관한 합성의약품 대비 한약의 효과에 대한 체계적 문헌고찰: PubMED를 중심으로

Systematic Review of the Effects of Herbal Medicine Versus Synthetic Drugs on Helicobacter Pylori Infection

  • 조은지 (상지대학교 한의과대학) ;
  • 정설 (상지대학교 한의과대학) ;
  • 곽승연 (상지대학교 한의과대학) ;
  • 정의민 (상지대학교 한의학과 내과학교실)
  • Cho, Eun Ji (College of Korean Medicine, Sangji University) ;
  • Jeong, Seol (College of Korean Medicine, Sangji University) ;
  • Gwak, Seung Yeon (College of Korean Medicine, Sangji University) ;
  • Jerng, Ui Min (Department of Korean Internal Medicine, College of Korean Medicine, Sangji University)
  • 투고 : 2021.08.09
  • 심사 : 2021.10.06
  • 발행 : 2021.11.30
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초록

Objective : This systematic review was conducted to investigate the effect of herbal medicine on Helicobacter pylori(H. pylori) infection compared to amoxicillin included synthetic drugs. Methods : Relevant randomized controlled trials(RCTs) which were published prior to December 26, 2020, were collected using PubMED database. Risk of bias evaluation and data extraction were done independently by two reviewers, and the third reviewer reassessed mismatching parts. Results : Two RCTs testing two different herbal medicines against synthetic drugs solitary treatment or synthetic drugs with placebo for herbal medicine were included. One study reported that there was no significant difference between the eradication rate of synthetic drugs and the herbal medicine. The other study did not report the eradication rate of the herbal medicine. One study reported histologic severity, the other reported dyspepsia score as efficacy indicators. There was no adverse event reported in all studies. However, the number of included RCTs was too small, the quality of reported data was not enough to verify efficacy of herbal medicine, and there were some methodological problems. Conclusion : It was difficult to conclude that solitary treatment of herbal medicine was as effective as amoxicillin included synthetic drugs for H. pylori infection.

키워드

과제정보

이 연구는 보건복지부의 지원을 받아 보건산업진흥원 과제(HF20C0002)의 지원을 받아 수행되었습니다.

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