DOI QR코드

DOI QR Code

User Interface Application for Cancer Classification using Histopathology Images

  • Naeem, Tayyaba (Research and Development Team, Humintec, Co. Ltd.) ;
  • Qamar, Shamweel (System Biomedical Informatics, Ajou University) ;
  • Park, Peom (Research and Development Team, Humintec, Co. Ltd.)
  • Received : 2021.10.18
  • Accepted : 2021.12.14
  • Published : 2021.12.31

Abstract

User interface for cancer classification system is a software application with clinician's friendly tools and functions to diagnose cancer from pathology images. Pathology evolved from manual diagnosis to computer-aided diagnosis with the help of Artificial Intelligence tools and algorithms. In this paper, we explained each block of the project life cycle for the implementation of automated breast cancer classification software using AI and machine learning algorithms to classify normal and invasive breast histology images. The system was designed to help the pathologists in an automatic and efficient diagnosis of breast cancer. To design the classification model, Hematoxylin and Eosin (H&E) stained breast histology images were obtained from the ICIAR Breast Cancer challenge. These images are stain normalized to minimize the error that can occur during model training due to pathological stains. The normalized dataset was fed into the ResNet-34 for the classification of normal and invasive breast cancer images. ResNet-34 gave 94% accuracy, 93% F Score, 95% of model Recall, and 91% precision.

Keywords

Acknowledgement

This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI18C0316)."

References

  1. Breast Cancer - WHO. World Health Organization, (2021)
  2. American Cancer Society. Surveillance Research, (2019)
  3. Ismail Jatoi, The Natural History of Breast Cancer. Surgical Clinics of North America, Science Direct, (2005)
  4. Asmaa Ibrahima, Paul Gamble, Ronnachai Jaroensri, Mohammed M.Abdelsamea, Craig H.Mermel, Po-Hsuan Cameron Chen, et al, Artificial intelligence in digital breast pathology: Techniques and applications, The Breast, SceinceDirect, (2019)
  5. Juanying Xie, Ran Liu, Joseph Luttrell IV and Chaoyang Zhang, Deep Learning Based Analysis of Histopathological Images of Breast Cancer, frontiers in Genetics, (2019)
  6. Shallu, Rajesh Mehra, Breast cancer histology images classification: Training from scratch or transfer learning? ICT Express, (2018)
  7. Alexander Rakhlin, Alexey Shvets, Vladimir Iglovikov, and Alexandr A. Kalinin, Deep Convolutional Neural Networks for Breast, arXiv, (2018)
  8. Kaushiki Roy, Debapriya Banik, Debotosh Bhattacharjee, Mita Nasipuri, Patch-based system for Classification of Breast Histology images using deep learning, Computerized Medical Imaging, and Graphics, (2019)
  9. BACH ICIAR 2018 Grand Challenge on Breast Cancer Histology, Retrieved from https://iciar2018-challenge.grand-challenge.org/, (2018)
  10. Abhishek Vahadane, Tingling Peng, Amit Sethi, Shadi Albarqouni, Lichao Wang, Maximilian Baust, et al., Structure-Preserving Color Normalization and Sparse Stain Separation for Histological Images, IEEE TRANSACTIONS ON MEDICAL IMAGING, (2016)
  11. Peter Byfield, StainTools, Retrieved from https://staintools.readthedocs.io/en/latest/, (2018)
  12. Deron Eriksson, Fei Hu, Whole-slide image preprocessing in Python, IBM, (2018)
  13. Rebecca Stone, Introducing py_wsi for computer analysis on whole slide .svs images using OpenSlide, (2018)
  14. Sandhya Armoogum Ph.D., Xiaoming Li Ph.D., Training Datasets, Retrieved from https://www.sciencedirect.com/topics/computer-science/training-datasets, (2019)
  15. Mingyu Gao, Dawei Qi, Hongbo Mu and Jianfeng Chen, A Transfer Residual Neural Network Based on ResNet-34, forests, MDPI, (2019)
  16. Valentina Alto, Neural Networks: parameters, hyperparameters, and optimization strategies, Retrieved from https://towardsdatascience.com/neural-networks-parameters-hyperparameters-and-optimization-strategies-3f0842fac0a5, (2019)
  17. Xinyue Wang, Bo Liu, Siyu Cao, Liping Jing & Jian Yu, Important sampling-based active learning for imbalanced classification, SpringerLink, (2020)
  18. Jason Brownlee, Random Oversampling and Undersampling for Imbalanced Classification Retrieved from https://machinelearningmastery.com/random-oversampling-and-undersampling-for-imbalanced-classification/. (2020)
  19. Agrawal, Astha; Herna L. Viktor, Eric Paquet, SCUT: Multi-class imbalanced data classification using SMOTE and cluster-based undersampling, IEEE Xplore, (2015)
  20. Neofytos Dimitriou, Ognjen Arandjelovic and Peter D. Caie, Deep Learning for Whole Slide Image Analysis: An Overview, frontiers in Medicine, (2019)