Journal of Microbiology and Biotechnology

  • 제30권11호
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  • Pages.1607-1613
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  • 2020
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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The Inhibitory Effect of Gut Microbiota and Its Metabolites on Colorectal Cancer

  • Chen, Chao (Department of Colorectal Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine) ;
  • Li, Huajun (Department of Microecology, College of Basic Medical Sciences, Dalian Medical University)
  • 투고 : 2020.02.17
  • 심사 : 2020.05.31
  • 발행 : 2020.11.28
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초록

Colorectal cancer (CRC) is regarded as one of the most common and deadly forms of cancer. Gut microbiota is vital to retain and promote several functions of intestinal. Although previous researches have shown that some gut microbiota have the abilities to inhibit tumorigenesis and prevent cancer from progressing, they have not yet clearly identified associative mechanisms. This review not only concentrates on the antitumor effects of metabolites produced by gut microbiota, for example, SCFA, ferrichrome, urolithins, equol and conjugated linoleic acids, but also the molecules which constituted the bacterial cell wall have the antitumor effect in the host, including lipopolysaccharide, lipoteichoic acid, β-glucans and peptidoglycan. The aim of our review is to develop a possible therapeutic method, which use the products of gut microbiota metabolism or gut microbiota constituents to help treat or prevent colorectal cancer.

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