The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Analgesic Effect of Blue Honeysuckle on the Rat Menopausal Pain, Primary Dysmenorrhea

Estradiol benzoate 및 oxytocin 투여로 유발된 랫트 생리통 모델에서 댕댕이나무 열매 농축동결건조 분말의 진통 및 생리장애 개선 효과

  • Joo, Si-Chan (Department of Herbology, College of Korea Medicine Daegu Haany University) ;
  • Lee, Sang-nam (Department of Qigong, College of Korea Medicine Daegu Haany University) ;
  • Choi, Seong-Hun (Department of anatomy and histology, College of Korea Medicine Daegu Haany University) ;
  • Park, Ji-Ha (Department of Herbology, College of Korea Medicine Daegu Haany University)
  • 주시찬 (대구한의대학교 한의과대학 본초학교실) ;
  • 이상남 (대구한의대학교 한의과대학 기공학교실) ;
  • 최성훈 (대구한의대학교 한의과대학 해부학교실) ;
  • 박지하 (대구한의대학교 한의과대학 본초학교실)
  • Received : 2020.11.12
  • Accepted : 2020.11.25
  • Published : 2020.11.30
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Abstract

Objectives : We observed the possibilities that blue honeysuckle has favorable analgesic or refinement effects on the Primary dysmenorrhea (PD) in rats. Methods : Estradiol benzoate and oxytocin were used to induce the PD rat model. And Blue honeysuckle concentration lyophilized powders (BH) 500, 250 and 125 mg/kg and 500 mg/kg of Lonicerae Flos aqueous extract lyophilized powders (LF) were orally administered, once a day for 10 days at 30 min after each estradiol benzoate treatment. Then the changes on the body weights and gains during experimental periods, abdominal writhing response for analgesic activities, uterine weights, uterus lipid peroxidation, antioxidant defense system - glutathione contents, superoxide dismutase and catalase activities, NF-κB and COX-2 mRNA expressions were monitored with uterus histopathology including immunohistochemistry for tumor necrosis factor (TNF)-α and inducible nitric oxide synthase (iNOS).. Results : Inflammatory and oxidative stress mediated PD signs were favorably and dose-dependently inhibited by 10 days continuous oral administration of three different dosages of BH - 500, 250 and 125 mg/kg as comparable to those of indomethacin(IND) 5 mg/kg treated rats in BH 500 mg/kg administered PD rats, and similar to those of LF 500 mg/kg in BH 125 mg/kg, at least in a condition of the present PD rat model. Conclusions : The results suggest that BH has favorable analgesic and refinement activities on the estradiol benzoate and oxytocin treatment-induced PD signs through anti-inflammatory and antioxidative potentials.

Keywords

References

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