The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Effect of Herbal Mixture including Lycii Fructus (HML) on Stress Relief and Melatonin in Caffeine and Light induced Stress Animal Model

Caffeine 및 광자극 유발 스트레스 동물모델에서 구기자 복합물이 스트레스 완화 및 혈중 멜라토닌에 미치는 영향

  • Kim, Ee-Hwa (Dept. of Meridian and Acupoint, College of Korean Medicine, Semyung University) ;
  • Hwang, Dong-Suk (Robin Korean Medical Clinic) ;
  • Kim, Hee-Taek (Dept. of Ophthalmology, Otolaryngology & Dermatology, College of Korean Medicine, Semyung University) ;
  • Kim, Yong-Min (Dept. of Cosmetic Science & Beauty Biotechnology, Semyung University)
  • 김이화 (세명대학교 한의과대학 경락경혈학교실) ;
  • 황동석 (로빈한의원) ;
  • 김희택 (세명대학교 한의과대학 한방안이비인후피부과학교실) ;
  • 김용민 (세명대학교 화장품.뷰티생명공학부)
  • Received : 2020.10.07
  • Accepted : 2020.10.31
  • Published : 2020.11.25
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Abstract

Objectives : In the present study, we investigated whether or not an herb mixture including Lycii fructus(HML) has attenuation effects on light stress in rats. Methods : Light stress was induced by exposure to 300 lx of constant lifht for 24 h and 1mg/kg of caffeine was injected into the rat. Rats were orally treated with distilled water of HML for 21 days at 100mg/kg/d. The changes of mortality rate, clinical signs, body, blood chemistry, melatonin and IL-2 expression were analyzed after experiment. Results : Normal weight changes were observed in all treatment groups. In addition, no changes were observed in dead animals and general symptoms. At the time of autopsy, the appearance of all groups and gross examination of major organs were observed, and no gross findings were observed. Blood biochemical tests showed that total cholesterol and HDL cholesterol levels were statistically significantly decreased in the group treated with HML compared to the stress-induced group. Melatonin was measured in the blood, but there was no significant difference in the group treated with HML compared to the group with stress-induced group, but it tended to increase. IL-2 was measured in the blood, no significant change was observed in the group treated with HML compared to the stress-induced group. Conclusions : According to the above results, HML maybe help with hematological changes expressed by caffeine and light-induced stress.

Keywords

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