Korean Journal of Exercise Nutrition (운동영양학회지)

한국운동영양학회
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Effects of endurance exercise under hypoxia on acid-base and ion balance in healthy males

  • Nam, Sang-Seok (Taekwondo Research Institute of Kukkiwon) ;
  • Park, Hun-Young (Department of Sports Medicine and Science of Graduated School, Konkuk University)
  • Received : 2020.08.24
  • Accepted : 2020.09.14
  • Published : 2020.09.30
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Abstract

[Purpose] This study was performed to investigate the acid-base and ion balance at rest and after exercise in healthy males under normoxia, moderate hypoxia, and severe hypoxia. [Methods] Ten healthy Korean males completed three different trials on different days, comprising exercise under normoxia (FiO2 = 20.9%, N trial), moderate hypoxia (FiO2 = 16.5%, MH trial), and severe hypoxia (FiO2 = 12.8%, SH trial). They undertook endurance exercise for 30 min on a cycle ergometer at the same relative exercise intensity equivalent to 80% maximal heart rate under all conditions. Capillary blood samples were obtained to determine acid-base and ion balance at rest and after exercise. [Results] Exercise-induced blood lactate elevations were significantly increased as hypoxic conditions became more severe; SH > MH > N trials (P = 0.003). After exercise, blood glucose levels were significantly higher in the SH trial than in the N and MH trials (P = 0.001). Capillary oxygen saturation (SCO2) levels were significantly lowered as hypoxic conditions became more severe; SH > MH > N trials (P < 0.001). The pH levels were significantly lower in the MH trial than that in the N trial (P = 0.010). Moreover, HCO3- levels were significantly lower in the SH trial than in the N trial, with significant interaction (P = 0.003). There were no significant differences in blood Na+, K+, and Ca2+ levels between the trials. [Conclusion] MH and SH trials induced greater differences in glucose, lactate, SCO2, pH, and HCO3- levels in capillary blood compared to the N trial. Additionally, lactate, SCO2, and HCO3- levels showed greater changes in the SH trial than in the MH trial. However, there were no significant differences in Na+, K+, and Ca2+ levels in MH and SH trials compared to the N trial.

Keywords

Acknowledgement

This work was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea (NRF-2019S1A5A2A03034583).

References

  1. Park HY, Hwang H, Park J, Lee S, Lim K. The effects of altitude/hypoxic training on oxygen delivery capacity of the blood and aerobic exercise capacity in elite athletes - a metaanalysis. J Exerc Nutrition Biochem. 2016;20:15-22. https://doi.org/10.20463/jenb.2016.03.20.1.3
  2. Park HY, Lim K. Effects of hypoxic training versus normoxic training on exercise performance in competitive swimmers. Med Sci Sports Exerc. 2017;16:480-8.
  3. Park HY, Lim K. Intermittent hypoxic training for 6 weeks in 3000 m hypobaric hypoxia conditions enhances exercise economy and aerobic exercise performance in moderately trained swimmers. Biol Sport. 2018;35:49-56. https://doi.org/10.5114/biolsport.2018.70751
  4. Brocherie F, Girard O, Faiss R, Millet GP. Effects of repeatedsprint training in hypoxia on sea-level performance: A metaanalysis. Sports Med. 2017;47:1651-60. https://doi.org/10.1007/s40279-017-0685-3
  5. Moon HW, Shin SH, Lee CH, Park HY, Sunoo S, Nam SS. Effects of various acute hypoxic conditions on the hemorheological response during exercise and recovery. Clin Hemorheol Microcirc. 2016;63:451-60. https://doi.org/10.3233/CH-16163
  6. Sinex JA, Chapman RF. Hypoxic training methods for improving endurance exercise performance. J Sport Health Sci. 2015;4:325-32. https://doi.org/10.1016/j.jshs.2015.07.005
  7. Moon HW, Sunoo S, Park HY, Lee DJ, Nam SS. Effects of various acute hypoxic conditions on metabolic parameters and cardiac function during exercise and recovery. SpringerPlus. 2016;5:1294. https://doi.org/10.1186/s40064-016-2952-4
  8. Katayama K, Goto K, Ishida K, Ogita F. Substrate utilization during exercise and recovery at moderate altitude. Metabolism. 2010;59:959-66. https://doi.org/10.1016/j.metabol.2009.10.017
  9. Sumi D, Kojima C, Goto K. Impact of endurance exercise in hypoxia on muscle damage, inflammatory and performance responses. J Strength Cond Res. 2018;32:1053-62. https://doi.org/10.1519/JSC.0000000000001911
  10. Sumi D, Kojima C, Kasai N, Goto K. The effects of endurance exercise in hypoxia on acid-base balance and potassium kinetics: a randomized crossover design in male endurance athletes. Sports Medicine - Open 2018;4:45. https://doi.org/10.1186/s40798-018-0160-1
  11. Juel C, Lundby C, Sander M, Calbet JAL, van Hall G. Human skeletal muscle and erythrocyte proteins involved in acidbase homeostasis: adaptations to chronic hypoxia. J Physiol. 2003;548:639-48. https://doi.org/10.1113/jphysiol.2002.035899
  12. Park HY, Sunoo S, Nam SS. The effects of 4 weeks fixed and mixed intermittent hypoxic training (IHT) on respiratory metabolic and acid-base response of capillary blood during submaximal bicycle exercise in male elite Taekwondo players. J Exerc Nutrition Biochem. 2016;20:35-43. https://doi.org/10.20463/jenb.2016.0035
  13. Mollard P, Woorons X, Letournel M, Lamberto C, Favret F, Pichon A, Beaudry M, Richalet JP. Determinant factors of the decrease in aerobic performance in moderate acute hypoxia in women endurance athletes. Respir Physiol Neurobiol. 2007;159:178-86. https://doi.org/10.1016/j.resp.2007.06.012
  14. Luhker O, Berger MM, Pohlmann A, Hotz L, Gruhlke T, Hochreiter M. Changes in acid-base and ion balance during exercise in normoxia and normobaric hypoxia. Eur J Appl Physiol. 2017;117:2251-61. https://doi.org/10.1007/s00421-017-3712-z
  15. Sejersted OM, Sjogaard G. Dynamics and consequences of potassium shifts n skeletal muscle and heart during exercise. Physiol Rev. 2000;80:1411-81. https://doi.org/10.1152/physrev.2000.80.4.1411
  16. Allen DG, Lamb GD, Westerblad H. Skeletal muscle fatigue: cellular echanisms. Physiol Rev. 2008;88:287-332. https://doi.org/10.1152/physrev.00015.2007
  17. McKenna MJ, Harmer AR, Fraser SF, Li JL. Effects of training on potassium, calcium and hydrogen ion regulation in skeletal muscle and blood during exercise. Acta Physiol Scand. 1996;156:335-46. https://doi.org/10.1046/j.1365-201X.1996.199000.x
  18. Street D, Nielsen JJ, Bangsbo J, Juel C. Metabolic alkalosis reduces exercise induced acidosis and potassium accumulation in human skeletal muscle interstitium. J Physiol. 2005;566:481-9. https://doi.org/10.1113/jphysiol.2005.086801
  19. Cairns SP, Lindinger MI. Do multiple ionic interactions contribute to skeletal muscle fatigue? J Physiol. 2008;586:4039-54. https://doi.org/10.1113/jphysiol.2008.155424
  20. Miyashita M, Mutoh Y, Yoshika Y, Sadamoto T. Effects of physical training. Med Sci Sports Exerc. 1985;1:3-5.
  21. Dar K, Williams T, Aitken R, Woods KL, Fletcher S. Arterial versus capillary sampling for analysing blood gas pressures. BMJ. 1995;310:24-5. https://doi.org/10.1136/bmj.310.6971.24
  22. Zavorsky GS, Cao J, Mayo NE, Gabbay R, Murias JM. Arterial versus capillary blood gases: A meta-analysis. Respi Physiol Neurobio. 2007;155:268-79. https://doi.org/10.1016/j.resp.2006.07.002
  23. Morishima T, Mori A, Sasaki H, Goto K. Impact of exercise and moderate hypoxia on glycemic regulation and substrate oxidation pattern. PLoS One 2014;9:e10862
  24. Sumi D, Kasai N, Ito H, Goto K. The effects of endurance exercise in hypoxia on acid-base, potassium kinetics, and exogenous glucose oxidation. Front Physiol. 2019;10:504. https://doi.org/10.3389/fphys.2019.00504
  25. Niess AM, Fehrenbach E, Strobel G, Roecker K, Schneider EM, Buergler J., Fuss S, Lehmann R, Northoff H, Dickhuth HH. Evaluation of stress responses to interval training at low and moderate altitudes. Med Sci Sports Exerc. 2003;35;263-9. https://doi.org/10.1249/01.MSS.0000048834.68889.81
  26. Woorons X, Mollard P, Lamberto C, Letournel M, Richalet JP. Effects of acute hypoxia on maximal exercise in trained and sedentary women. Med Sci Sports Exerc. 2005;37:147-54. https://doi.org/10.1249/01.MSS.0000150020.25153.34
  27. Nielsen HB, Hein L, Svendsen LB, Secher NH, Quistorff, B. Bicarbonate attenuates intracellular acidosis. Acta Anaesthesiol Scand. 2002;46:579-84. https://doi.org/10.1034/j.1399-6576.2002.460516.x