Korean Journal of Exercise Nutrition (운동영양학회지)

한국운동영양학회
권호 표지
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Hypoxic exposure can improve blood glycemic control in high-fat diet-induced obese mice.

  • Park, Yeram (Department of Physical Education in Graduated school, Konkuk University) ;
  • Jang, Inkwon (Department of Sports Medicine and Science in Graduated School, Konkuk University) ;
  • Park, Hun-Young (Department of Sports Medicine and Science in Graduated School, Konkuk University) ;
  • Kim, Jisu (Department of Sports Medicine and Science in Graduated School, Konkuk University) ;
  • Lim, Kiwon (Department of Physical Education in Graduated school, Konkuk University)
  • Received : 2020.03.09
  • Accepted : 2020.03.26
  • Published : 2020.03.31
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Abstract

[Purpose] Blood glucose and insulin resistance were lower following hypoxic exposure in previous studies. However, the effect of hypoxia as therapy in obese model has not been unknown. [Methods] Six-week-old mice were randomly divided into chow diet (n=10) and high-fat diet (HFD) groups (n=20). The chow diet group received a non-purified commercial diet (65 % carbohydrate, 21 % protein, and 14 % fat) and water ad libitum. The HFD group was fed an HFD (Research Diet, #D12492; 60% kcal from fat, 5.24 kcal/g). Both groups consumed their respective diet for 7 weeks. Subsequently, HFD-induced mice (12-weeks-old) were randomly divided into two treatment groups : HFD-Normoxia (HFD; n=10) and HFD-Hypoxia (HYP; n=10, fraction of inspired=14.6%). After treatment for 4 weeks, serum glucose, insulin and oral glucose tolerance tests (OGTT) were performed. [Results] Homeostatic model assessment values for insulin resistance (HOMA-IR) of the HYP group tended to be lower than the HFD group. Regarding the OGTT, the area under the curve was 13% lower for the HYP group than the HFD group. [Conclusion] Insulin resistance tended to be lower and glucose uptake capacity was significantly augmented under hypoxia. From a clinical perspective, exposure to hypoxia may be a practical method of treating obesity.

Keywords

Acknowledgement

KL(corresponding author) and HYP contributed to the design of all experiments and interpreted the results of the data. HYP and JK interpreted the results of the data and revised the paper. YP collected the data, undertook the statistical analyses, and wrote the manuscript. IJ carried out the studies and provided technical support. All of the authors read and approved the final manuscript. The authors would like to thank the Exercise & Nutrition Laboratory for their excellent laboratory work. This work was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea (NRF-2019S1A5A2A03034583).

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