Korean Journal of Exercise Nutrition (운동영양학회지)

한국운동영양학회
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The effect of dehydroepiandrosterone administration on intestinal calcium absorption in ovariectomized female rats

  • Hattori, Satoshi (Faculty of Health and Sport Sciences, University of Tsukuba) ;
  • Park, Suhan (Comprehensive Human Sciences, University of Tsukuba) ;
  • Park, Jong-hoon (Department of Physical Education, Korea University) ;
  • Omi, Naomi (Faculty of Health and Sport Sciences, University of Tsukuba)
  • Received : 2020.09.06
  • Accepted : 2020.12.11
  • Published : 2020.12.31
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Abstract

[Purpose] Dehydroepiandrosterone (DHEA) administration reportedly recovers osteoporosis, a bone disorder associated with bone deficiency in postmenopausal women. However, the physiological mechanism of DHEA in osteoporosis remains elusive, especially in terms of intestinal calcium absorption. Therefore, we investigated the effect of DHEA administration on calcium absorption in ovariectomized (OVX) female rats using an estrogen receptor antagonist. [Methods] Female Sprague-Dawley rats (n=23, 6 weeks old) were randomized into three groups: OVX control group (OC, n=7), OVX with DHEA treatment group (OD, n=8), and OVX with DHEA inhibitor group (ODI, n=8) for 8 weeks. [Results] Intestinal calcium accumulation, as well as the rate of absorption, demonstrated no significant differences during the experimental period among investigated groups. The bone mineral density (BMD) of the tibia at the proximal metaphysis was higher in the OD group than that in the OC group (p<0.05); however, BMD of the ODI group showed no significant difference from investigated groups. Furthermore, the BMD of the tibia at the diaphysis did not significantly differ among these groups. [Conclusion] We revealed that DHEA administration does not involve intestinal Ca absorption, although this treatment improves BMD levels in OVX rats. These observations indicate that the effect of DHEA on the bone in postmenopausal women is solely due to its influence on bone metabolism and not intestinal calcium absorption.

Keywords

Acknowledgement

We would like to thank the members of the exercise and nutrition laboratory at the University of Tsukuba for useful discussions and support.

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