Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Role of glutathione redox system on the susceptibility to deoxynivalenol of pheasant (Phasianus colchicus)

  • Fernye, Csaba (Department of Nutrition, Faculty of Agricultural Environmental Sciences, Szent Istvan University) ;
  • Ancsin, Zsolt (Department of Nutrition, Faculty of Agricultural Environmental Sciences, Szent Istvan University) ;
  • Erdelyi, Marta (Department of Nutrition, Faculty of Agricultural Environmental Sciences, Szent Istvan University) ;
  • Mezes, Miklos (Department of Nutrition, Faculty of Agricultural Environmental Sciences, Szent Istvan University) ;
  • Balogh, Krisztian (Department of Nutrition, Faculty of Agricultural Environmental Sciences, Szent Istvan University)
  • Received : 2018.10.12
  • Accepted : 2019.05.30
  • Published : 2020.04.15
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Abstract

There are only a few reports on the effects of mycotoxins on pheasant (Phasianus colchicus) and the susceptibility to deoxynivalenol of these birds have never been reported before. The present experiment focuses to investigate the effects of different dietary concentrations of deoxynivalenol on blood plasma protein content, some parameters of lipid peroxidation and glutathione redox system and on the performance of pheasant chicks. A total of 320 1-day-old female pheasants were randomly assigned to four treatment groups fed with a diet contaminated with deoxynivalenol (control, 5.11 mg/kg, 11.68 mg/kg and 16.89 mg/kg). Birds were sacrificed at early (12, 24 and 72 h) and late (1, 2 and 3 weeks) stages of the experiment to demonstrate the oxidative stress-inducing effect of deoxynivalenol. Feed refusal was dose dependent, especially in the last third of the trial, but only minor body weight gain decrease was found. Lipid-peroxidation parameters did not show dose-dependent effect, except in blood plasma during the early stage of the trial. The glutathione redox system, reduced glutathione content and glutathione peroxidase activity, was activated in the liver, but primarily in the blood plasma. Glutathione peroxidase activity has changed parallel with reduced glutathione concentration in all tissues. Comparing our results with literature data, pheasants seem to have the same or higher tolerance to deoxynivalenol than other avian species, and glutathione redox system might contribute in some extent to this tolerance, as effective antioxidant defence against oxidative stress.

Keywords

Acknowledgement

Open access funding provided by Szent Istvan University (SZIE). The research was supported by the EFOP-3.6.3-VEKOP-16-2017-00008 project, co-financed by the European Union and the European Social Fund to CF, KB, MM and ME.

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