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Critical illness neuromyopathy

  • Park, Soo-Hyun (Department of Neurology, Inha University Hospital) ;
  • Jeong, Yoon-Jung (Department of Internal Medicine, Dongguk University Ilsan Hospital) ;
  • Kim, Nam-Hee (Department of Neurology, Dongguk University Ilsan Hospital)
  • Received : 2020.07.31
  • Accepted : 2020.08.23
  • Published : 2020.10.31

Abstract

Critical illness neuromyopathy (CINM) is a common but frequently underdiagnosed condition in critically ill patients that contributes to ventilator weaning failure and limb weakness in intensive care unit (ICU). CINM is subdivided into critical illness polyneuropathy and critical illness myopathy, and the occurrence of these conditions in the ICU is associated with multiple organ failure due to sepsis or certain medications. CINM survivors might have persistent functional disabilities and a poor quality of life. This situation demonstrates the need for efforts to minimize or prevent CINM in critically ill patients. This article provides a current overview of CINM and the associated clinical strategies.

Keywords

References

  1. Bolton CF. Neuromuscular manifestations of critical illness. Muscle Nerve 2005;32:140-163. https://doi.org/10.1002/mus.20304
  2. Lacomis D, Petrella JT, Giuliani MJ. Causes of neuromuscular weakness in the intensive care unit: a study of ninety-two patients. Muscle Nerve 1998;21:610-617. https://doi.org/10.1002/(SICI)1097-4598(199805)21:5<610::AID-MUS7>3.0.CO;2-B
  3. Hund E. Neurological complications of sepsis: critical illness polyneuropathy and myopathy. J Neurol 2001;248:929-934. https://doi.org/10.1007/s004150170043
  4. De Jonghe B, Sharshar T, Lefaucheur JP, Authier FJ, Durand-Zaleski I, Boussarsar M, et al. Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA 2002;288:2859-2867. https://doi.org/10.1001/jama.288.22.2859
  5. Dhand UK. Clinical approach to the weak patient in the intensive care unit. Respir Care 2006;51:1024-1041.
  6. Olsen CW. Lesions of peripheral nerves developing during coma. J Am Med Assoc 1956;160:39-41. https://doi.org/10.1001/jama.1956.02960360041008
  7. Bolton CF, Gilbert JJ, Hahn AF, Sibbald WJ. Polyneuropathy in critically ill patients. J Neurol Neurosurg Psychiatry 1984;47:1223-1231. https://doi.org/10.1136/jnnp.47.11.1223
  8. MacFarlane IA, Rosenthal FD. Severe myopathy after status asthmaticus. Lancet 1977;2:615. https://doi.org/10.1016/S0140-6736(77)91471-4
  9. Lacomis D, Zochodne DW, Bird SJ. Critical illness myopathy. Muscle Nerve 2000;23:1785-1788. https://doi.org/10.1002/1097-4598(200012)23:12<1785::AID-MUS1>3.0.CO;2-J
  10. Latronico N, Bolton CF. Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. Lancet Neurol 2011;10:931-941. https://doi.org/10.1016/S1474-4422(11)70178-8
  11. Visser LH. Critical illness polyneuropathy and myopathy: clinical features, risk factors and prognosis. Eur J Neurol 2006;13:1203-1212. https://doi.org/10.1111/j.1468-1331.2006.01498.x
  12. Kress JP, Hall JB. ICU-acquired weakness and recovery from critical illness. N Engl J Med 2014;371:287-288. https://doi.org/10.1056/NEJMc1406274
  13. Jolley SE, Bunnell AE, Hough CL. ICU-acquired weakness. Chest 2016;150:1129-1140. https://doi.org/10.1016/j.chest.2016.03.045
  14. Witteveen E, Wieske L, Verhamme C, Schultz MJ, van Schaik IN, Horn J. Muscle and nerve inflammation in intensive care unit-acquired weakness: a systematic translational review. J Neurol Sci 2014;345:15-25. https://doi.org/10.1016/j.jns.2014.07.014
  15. Shepherd S, Batra A, Lerner DP. Review of critical illness myopathy and neuropathy. Neurohospitalist 2017;7:41-48. https://doi.org/10.1177/1941874416663279
  16. De Jonghe B, Lacherade JC, Durand MC, Sharshar T. Critical illness neuromuscular syndromes. Neurol Clin 2008;26:507-520. https://doi.org/10.1016/j.ncl.2008.03.001
  17. Pandit L, Agrawal A. Neuromuscular disorders in critical illness. Clin Neurol Neurosurg 2006;108:621-627. https://doi.org/10.1016/j.clineuro.2006.04.003
  18. Stevens RD, Marshall SA, Cornblath DR, Hoke A, Needham DM, de Jonghe B, et al. A framework for diagnosing and classifying intensive care unit-acquired weakness. Crit Care Med 2009;37:S299-S308. https://doi.org/10.1097/CCM.0b013e3181b6ef67
  19. Lorin S, Nierman DM. Critical illness neuromuscular abnormalities. Crit Care Clin 2002;18:553-568. https://doi.org/10.1016/S0749-0704(02)00003-9
  20. Stevens RD, Dowdy DW, Michaels RK, Mendez-Tellez PA, Pronovost PJ, Needham DM. Neuromuscular dysfunction acquired in critical illness: a systematic review. Intensive Care Med 2007;33:1876-1891. https://doi.org/10.1007/s00134-007-0772-2
  21. Apostolakis E, Papakonstantinou NA, Baikoussis NG, Papadopoulos G. Intensive care unit-related generalized neuromuscular weakness due to critical illness polyneuropathy/myopathy in critically ill patients. J Anesth 2015;29:112-121. https://doi.org/10.1007/s00540-014-1875-x
  22. De Letter MA, van Doorn PA, Savelkoul HF, Laman JD, Schmitz PI, Op de Coul AA, et al. Critical illness polyneuropathy and myopathy (CIPNM): evidence for local immune activation by cytokine-expression in the muscle tissue. J Neuroimmunol 2000;106:206-213. https://doi.org/10.1016/S0165-5728(99)00252-0
  23. Garnacho-Montero J, Madrazo-Osuna J, Garcia-Garmendia JL, Ortiz-Leyba C, Jimenez-Jimenez FJ, Barrero-Almodovar A, et al. Critical illness polyneuropathy: risk factors and clinical consequences. A cohort study in septic patients. Intensive Care Med 2001;27:1288-1296. https://doi.org/10.1007/s001340101009
  24. Zifko UA, Zipko HT, Bolton CF. Clinical and electrophysiological findings in critical illness polyneuropathy. J Neurol Sci 1998;159:186-193. https://doi.org/10.1016/S0022-510X(98)00164-6
  25. Tennila A, Salmi T, Pettila V, Roine RO, Varpula T, Takkunen O. Early signs of critical illness polyneuropathy in ICU patients with systemic inflammatory response syndrome or sepsis. Intensive Care Med 2000;26:1360-1363. https://doi.org/10.1007/s001340000586
  26. Khan J, Harrison TB, Rich MM, Moss M. Early development of critical illness myopathy and neuropathy in patients with severe sepsis. Neurology 2006;67:1421-1425. https://doi.org/10.1212/01.wnl.0000239826.63523.8e
  27. Johnson KL. Neuromuscular complications in the intensive care unit: critical illness polyneuromyopathy. AACN Adv Crit Care 2007;18:167-180. https://doi.org/10.1097/01.AACN.0000269260.99169.70
  28. Rich MM, Bird SJ, Raps EC, McCluskey LF, Teener JW. Direct muscle stimulation in acute quadriplegic myopathy. Muscle Nerve 1997;20:665-673. https://doi.org/10.1002/(SICI)1097-4598(199706)20:6<665::AID-MUS2>3.0.CO;2-6
  29. Koch S, Spuler S, Deja M, Bierbrauer J, Dimroth A, Behse F, et al. Critical illness myopathy is frequent: accompanying neuropathy protracts ICU discharge. J Neurol Neurosurg Psychiatry 2011;82:287-293. https://doi.org/10.1136/jnnp.2009.192997
  30. Sitwell LD, Weinshenker BG, Monpetit V, Reid D. Complete ophthalmoplegia as a complication of acute corticosteroid-and pancuronium-associated myopathy. Neurology 1991;41:921-922. https://doi.org/10.1212/WNL.41.6.921
  31. Van den Berghe G, Schoonheydt K, Becx P, Bruyninckx F, Wouters PJ. Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology 2005;64:1348-1353. https://doi.org/10.1212/01.WNL.0000158442.08857.FC
  32. Zhou C, Wu L, Ni F, Ji W, Wu J, Zhang H. Critical illness polyneuropathy and myopathy: a systematic review. Neural Regen Res 2014;9:101-110. https://doi.org/10.4103/1673-5374.125337
  33. Mohr M, Englisch L, Roth A, Burchardi H, Zielmann S. Effects of early treatment with immunoglobulin on critical illness polyneuropathy following multiple organ failure and gram-negative sepsis. Intensive Care Med 1997;23:1144-1149. https://doi.org/10.1007/s001340050471
  34. Hermans G, De Jonghe B, Bruyninckx F, Van den Berghe G. Interventions for preventing critical illness polyneuropathy and critical illness myopathy. Cochrane Database Syst Rev 2014;(1):CD006832.
  35. Berek K, Margreiter J, Willeit J, Berek A, Schmutzhard E, Mutz NJ. Polyneuropathies in critically ill patients: a prospective evaluation. Intensive Care Med 1996;22:849-855. https://doi.org/10.1007/BF02044106
  36. Leijten FS, Harinck-de Weerd JE, Poortvliet DC, de Weerd AW. The role of polyneuropathy in motor convalescence after prolonged mechanical ventilation. JAMA 1995;274:1221-1225. https://doi.org/10.1001/jama.1995.03530150045032
  37. Campellone JV, Lacomis D, Kramer DJ, Van Cott AC, Giuliani MJ. Acute myopathy after liver transplantation. Neurology 1998;50:46-53. https://doi.org/10.1212/WNL.50.3_Suppl_2.46