Textile Science and Engineering (한국섬유공학회지)

The Korean Fiber Society (한국섬유공학회)
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Synthesis and Drug Release Property of Poly(ethylene glycol-block-L-lactide-block-N-isopropylacrylamide) Triblock Copolymer

Poly(ethylene glycol-block-L-lactide-block-N-isopropylacrylamide) 삼중 블록 공중합체의 합성과 약물 방출성

  • 정수진 ((주)타우피엔유메디칼) ;
  • 김홍성 (부산대학교 바이오소재과학과)
  • Received : 2020.09.28
  • Accepted : 2020.10.11
  • Published : 2020.10.31
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Abstract

Herein, novel linear block copolymers have been synthesized for use as a drug-eluting coating material in vascular grafts. Poly(ethylene glycol-block-L-lactide-block-N-isopropylacrylamide) triblock copolymers were prepared by stepwise polymerization from methoxy-terminated polyethylene glycol, i.e., anionic ring-opening polymerization of L-lactide followed by quasi-living polymerization of N-isopropylacrylamide. The chemical structures of the triblock copolymers were analyzed by FT-IR spectroscopy, 1H-NMR spectroscopy, and WAXD. The surface adhesion of triblock copolymers was evaluated for the substrate and model proteins. The drug release behavior of antiproliferative methotrexate was investigated according to the block ratio of the triblock copolymers. Viscosity increased significantly with increasing proportion of poly(N-isopropylacrylamide) block, whereas protein adhesion decreased with decreasing proportion of poly(L-lactide) block. Furthermore, methotrexate release increased with decreasing proportion of poly(L-lactide) block, and both the initial and sustained release increased with increasing proportion of poly(N-isopropyl acrylamide) block. This triblock copolymer can adjust the ratio of blocks to design effective drug release for specific applications.

Keywords

Acknowledgement

이 과제는 부산대학교 기본연구지원사업(2년)에 의하여 연구되었음.

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