Child Health Nursing Research

Korean Academy of Child Health Nursing (한국아동간호학회)
권호 표지
DOI QR코드

DOI QR Code

Health-related Quality of Life of Children and Adolescents after Hematopoietic Stem Cell Transplantation

  • Hwang, Yu Min (Registered Nurse, Seoul National University Hospital) ;
  • Bang, Kyung-Sook (College of Nursing, Research Institute of Nursing Science, Seoul National University)
  • Received : 2020.07.18
  • Accepted : 2020.09.19
  • Published : 2020.10.31
Download PDF
⟨ Previous Next ⟩

Abstract

Purpose: This study aimed to determine the level of health-related quality of life (HRQoL) of children and adolescents who received hematopoietic stem cell transplantation (HSCT) and to examine factors influencing HRQoL. Methods: This cross-sectional descriptive study involved 85 participants aged 10 to 19 years who received treatment from 3 months to 5 years after HSCT. Symptom experiences, stress and coping, self-esteem, social support, and HRQoL were measured. Descriptive analysis, the independent t-test, one-way analysis of variance, Pearson correlation analysis, and stepwise multiple regression were used for data analysis. Results: The mean HRQoL score was 72.26 points out of 100. HRQoL showed statistically significant correlations with symptom experiences, stress, self-esteem, social support, satisfaction with peer relationships, and perceived attentiveness of the medical team. The most influential predictors of HRQoL were symptom experiences (β=-.51, p<.001) and satisfaction with peer relationships (β=.32, p<.001). Conclusion: The experiences of different symptoms by children and adolescents who receive HSCT must be considered. In addition, nursing interventions, such as self-help meetings with peer groups, should be provided to improve their HRQoL.

Keywords

References

  1. Gratwohl A, Baldomero H, Aljurf M, Pasquini MC, Bouzas LF, Yoshimi A, et al. Hematopoietic stem cell transplantation: A global perspective. Journal of American Medical Association. 2010;303(16): 1617-1624. https://doi.org/10.1001/jama.2010.491
  2. Grant M, Cooke L, Williams AC, Bhatia S, Popplewell L, Uman G, et al. Functional status and health-related quality of life among allogeneic transplant patients at hospital discharge: A comparison of sociodemographic, disease, and treatment characteristics. Supportive Care in Cancer. 2012;20(11):2697-2704. https://doi.org/10.1007/s00520-012-1389-8
  3. Kiss TL, Abdolell M, Jamal N, Minden MD, Lipton JH, Messner HA. Long term medical outcomes and quality of life assessment of patients with chronic myeloid leukemia followed at least 10 years after allogeneic bone marrow transplantation. Journal of Clinical Oncology. 2002;20(9):2334-2343. https://doi.org/10.1200/JCO.2002.06.077
  4. Kim SY, Shim JY, Won JW, Seon WS, Park HK, Lee JK. The development of Korean health related quality of life scale (KQOLS). Journal of the Korean Academy of Family Medicine. 2000;21(3): 382-394. https://ir.ymlib.yonsei.ac.kr/handle/22282913/171948
  5. Bhatia S, Landier W. Evaluating survivors of pediatric cancer. Cancer Journal. 2005;11(4):340-354. https://doi.org/10.1097/00130404-200507000-00010
  6. Oh KS, Sim MK, Son SY. Health problems and psychosocial adaptation of children with cancer. Journal of Korean Academy of Nursing. 2003;33(2):293-300. https://doi.org/10.4040/jkan.2003.33.2.293
  7. Kazak AE, Alderfer M, Rourke MT, Simms S, Streisand R, Grossman JR. Post-traumatic stress disorder (PTSD) and posttraumatic stress symptoms (PTSS) in families of adolescent childhood cancer survivors. Journal of Pediatric Psychology. 2004;29(3):211-219. https://doi.org/10.1093/jpepsy/jsh022
  8. Woodgate RL. A different way of being: Adolescent's experiences with cancer. Cancer Nursing. 2005;28(1):8-15. https://doi.org/10.1097/00002820-200501000-00002
  9. Cho HH, Yoon JW. Trends in research on children with cancer and their families in Korea. Journal of Korean Academy of Child Health Nursing. 2010;16(1):73-83. https://doi.org/10.4094/jkachn.2010.16.1.73
  10. Larsen J, Nordstrom G, Bjorkstrand B, Ljungman P, Gardulf A. Symptom distress, functional status and health related quality of life before high dose chemotherapy with stem cell transplantation. European Journal of Cancer Care. 2003;12(1):71-80. https://doi.org/10.1046/j.1365-2354.2003.00315.x
  11. Kim KJ. Differences of symptom experiences according to gender and stage in hematopoietic stem cell transplant process [master's thesis]. Seoul: Yonsei University; 2004. p. 1-101.
  12. Cline ME, Herman J, Shaw ER, Morton RD. Standardization of the visual analogue scale. Nursing Research. 1992;41(6):378-380. https://doi.org/10.1097/00006199-199211000-00013
  13. Park JA, Chung MJ. Relationships between strategies for coping with stress and behavior problem in school-age children. Korean Journal of Child Studies. 2001;22(3):107-122.
  14. Lee HJ, Won HT. Self-concepts and paranoid tendency. Seoul National University Research Institute of Psychology and Sciences. 1995;4(2):15-29.
  15. Zimet GD, Dahlem NW, Zimet SG, Farley GK. The multidimensional scale of perceived social support. Journal of Personality Assessment. 1988;52(1):30-41. https://doi.org/10.1207/s15327752jpa5201_2
  16. Hong SS, Park HR. Predictors of resilience in adolescents with leukemia. Journal of Korean Academy of Nursing. 2015;45(4):595-603. https://doi.org/10.4040/jkan.2015.45.4.595
  17. Varni JW, Seid M, Kurtin PS. PedsQL 4.0TM: Reliability and validity of the Pediatric Quality of Life Inventory TM Version 4.0 Generic Core Scales in healthy and patient populations. Medical Care. 2001;39(8):800-812. https://doi.org/10.1097/00005650-200108000-00006
  18. Kook SH, Varni JW. Validation of the Korean version of the pediatric quality of life inventory 4.0 (PedsQL) generic core scales in school children and adolescents using the Rasch model. Health and Quality of Life Outcomes. 2008;41:6-41. https://doi.org/10.1186/1477-7525-6-41
  19. Nuss SL, Wilson ME. Health-related quality of life following hematopoietic stem cell transplant during childhood. Journal of Pediatric Oncology Nursing. 2007;24(2):106-115. https://doi.org/10.1177/1043454206296033
  20. Clarke SA, Skinner R, Guest J, Darbyshire P, Cooper J, Vora A, et al. Clinical outcomes and health-related quality of life (HRQOL) following hematopoietic stem cell transplantation (HSCT) for pediatric leukemia. Child. 2011;37(4):571-580. https://doi.org/10.1111/j.1365-2214.2010.01182.x
  21. Park MN. Descriptive study on self-identity, resilience and health related quality of life in adolescent survivors with cancer [master's thesis]. Seoul: Yonsei University; 2016. p. 1-95.
  22. Michel G, Bordigoni P, Simeoni MC, Curtillet C, Hoxha S, Robitail S, et al. Health status and quality of life in long-term survivors of childhood leukemia: The impact of hematopoietic stem cell transplantation. Bone Marrow Transplantation. 2007;40(9):897-904. https://doi.org/10.1038/sj.bmt.1705821
  23. Kim YJ, Kwon HJ. The experiences of adolescents' suffering from cancer: Breaking out of the withdrawn Ego. Asian Oncology Nursing. 2013;13(4):304-312. https://doi.org/10.5388/aon.2013.13.4.304
  24. Shin HG. Influencing factors of quality of life, self-esteem of higher grade primary school children. Journal of the Korean Data Analysis Society. 2015;17(1):485-499.
  25. Oh SM, Lee HJ, Kim GS, Part KD. Factors affecting social adjustment of childhood cancer survivors. Child Health Nursing Research. 2013;19(3):238-245. https://doi.org/10.4094/chnr.2013.19.3.238
  26. Son SY. Illness experience of adolescents with hematologic malignancies. Journal of Korean Academy of Nursing. 2011;41(5):603-612. https://doi.org/10.4040/jkan.2011.41.5.603
  27. Finnegan L, Campbell RT, Ferrans CE, Wilbur JE, Wilkie DJ, Shaver J. Symptom cluster experience profiles in adult survivors of childhood cancers. Journal of Pain and Symptom Management. 2009;38(2):258-269. https://doi.org/10.1016/j.jpainsymman.2008.09.010
  28. Ritchie MA. Self-esteem and hopefulness in adolescents with cancer. Journal of Pediatric Nursing. 2001;16(1):35-42. https://doi.org/10.1053/jpdn.2001.20551
  29. Haase JE, Kintner EK, Monahan PO, Robb SL. The resilience in illness model. Part 1: Exploratory evaluation in adolescents and young adults with cancer. Cancer Nursing. 2014;37(3):E1-E12. https://doi.org/10.1097/NCC.0b013e31828941bb

Cited by

  1. Body image, self-esteem, and quality of life in children and adolescents with inflammatory bowel disease in a tertiary hospital in South Korea vol.27, pp.2, 2020, https://doi.org/10.4094/chnr.2021.27.2.181