Asian-Australasian Journal of Animal Sciences

  • 제33권12호
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  • Pages.1985-1990
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  • 2020
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  • 1011-2367(pISSN)
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  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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Distribution of injected fat-soluble vitamins in plasma and tissues of nursery pigs

  • Jang, Young Dal (Department of Animal and Food Science, University of Wisconsin-River Falls) ;
  • Rotering, Mikayla J. (Department of Animal and Food Science, University of Wisconsin-River Falls) ;
  • Isensee, Paige K. (Department of Animal and Food Science, University of Wisconsin-River Falls) ;
  • Rinholen, Kirsten A. (Department of Animal and Food Science, University of Wisconsin-River Falls) ;
  • Boston-Denton, Carli J. (Department of Animal and Food Science, University of Wisconsin-River Falls) ;
  • Kelley, Paige G. (Department of Animal and Food Science, University of Wisconsin-River Falls) ;
  • Stuart, Robert L. (Stuart Products Inc.)
  • 투고 : 2019.12.28
  • 심사 : 2020.03.24
  • 발행 : 2020.12.01
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초록

Objective: The objective of this experiment was to investigate the effects of fat-soluble vitamin injection on plasma and tissue vitamin status in nursery pigs. Methods: A total of 16 pigs (initial body weight: 7.15±1.1 kg) were allotted to 2 treatments at d 7 post-weaning. Pigs were fed a corn-soybean meal-based basal diet with no supplemental vitamin A and i.m. injected with 300,000 IU of retinyl palmitate, 900 IU of d-α-tocopherol and 30,000 IU of vitamin D3 with control pigs having no vitamin injection. Blood (d 0, 3, 7, and 14 post-injection) and tissue samples (liver, brain, heart, lung, and muscle; d 7 and 14 post-injection) were collected from pigs. Retinyl palmitate, retinol, and α-tocopherol concentrations were analyzed in plasma and tissues, while plasma was assayed for 25-hydroxycholecalciferol (25-OHD3). Results: Plasma retinol and 25-OHD3 concentrations increased by the vitamin injection from d 3 to 14 post-injection (p<0.05) whereas plasma retinyl palmitate was detected only in the vitamin treatment at d 3 and 7 post-injection (115.51 and 4.97 ㎍/mL, respectively). Liver retinol, retinyl palmitate, and retinol+retinyl palmitate concentrations increased by retinyl palmitate injection at d 7 and 14 post-injection (p<0.05) whereas those were not detected in the other tissues. The d-α-tocopherol injection increased α-tocopherol concentrations in plasma at d 3 and 7 post-injection (p<0.05) and in liver, heart (p<0.10), and muscle (p<0.05) at d 7 post-injection. Conclusion: Fat-soluble vitamin injection increased plasma status of α-tocopherol, retinol, retinyl palmitate and 25-OHD3. As plasma levels decreased post-injection, vitamin A level in liver and vitamin E level in muscle, heart and liver increased. The α-tocopherol found in plasma after injection was distributed to various tissues but retinyl palmitate only to the liver.

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참고문헌

  1. McDowell LR. Vitamins in animal and human nutrition. 2nd ed. Ames, IA, USA: Iowa State University Press; 2000.
  2. Horst RL, Littledike ET. Comparison of plasma concentrations of vitamin D and its metabolites in young and aged domestic animals. Comp Biochem Physiol B 1982;73:485-9. https://doi.org/10.1016/0305-0491(82)90064-5
  3. Hakansson J, Hakkarainen J, Lundeheim N. Variation in vitamin E, glutathione peroxidase and retinol concentrations in blood plasma of primiparous sows and their piglets, and in vitamin E, selenium and retinol contents in sows' milk. Acta Agric Scand Sect A-Animal Sci 2001;51:224-34. https://doi.org/10.1080/09064700152717209
  4. Jang YD, Lindemann MD, Monegue HJ, Stuart RL. The effects of fat-soluble vitamin administration on plasma vitamin status of nursing pigs differ when provided by oral administration or injection. Asian-Astralas J Anim Sci 2014;27:674-82. https://doi.org/10.5713/ajas.2013.13802
  5. Jang YD, Ma JY, Monegue JS, Monegue HJ, Stuart RL, Lindemann MD. Temporal plasma vitamin concentrations are altered by fat-soluble vitamin administration in suckling pigs. J Anim Sci 2015;93:5273-82. https://doi.org/10.2527/jas.2015-9221
  6. Jang YD, Ma JY, Lu N, et al. Administration of vitamin D3 by injection or drinking water alters serum 25-hydroxycholecalciferol concentrations of nursery pigs. Asian-Australas J Anim Sci 2018;31:278-86. https://doi.org/10.5713/ajas.17.0397
  7. Underwood BA, Loerch JD, Lewis KC. Effects of dietary vitamin A deficiency, retinoic acid and protein quantity and quality on serially obtained plasma and liver levels of vitamin A in rats. J Nutr 1979;109:796-806. https://doi.org/10.1093/jn/109.5.796
  8. Committee on Nutrient Requirements of Swine, National Research Council. Nutrient requirements of swine. 11th ed. Washington, DC, USA: National Academy Press; 2012.
  9. O'Byrne SM, Blaner WS. Retinol and retinyl esters: biochemistry and physiology. J Lipid Res 2013;54:1731-43. https://doi.org/10.1194/jlr.R037648
  10. Majchrzak D, Fabian E, Elmadfa I. Vitamin A content (retinol and retinyl esters) in livers of different animals. Food Chem 2006;98:704-10. https://doi.org/10.1016/j.foodchem.2005.06.035
  11. Sun T, Surles RL, Tanumihardjo SA. Vitamin A concentrations in piglet extrahepatic tissues respond differently ten days after vitamin A treatment. J Nutr 2008;138:1101-6. https://doi.org/10.1093/jn/138.6.1101
  12. Pardo DC. Vitamin E: pharmacokinetics of parenteral products and its effect on swine reproduction [dissertation]. Ames, IA, USA: Iowa State University; 1995.
  13. Lauridsen C, Engel H, Jensen SK, Morrie Craig A, Traber MG. Lactating sows and suckling piglets preferentially incorporate RRR- over All-rac-$\alpha$-tocopherol into milk, plasma and tissues. J Nutr 2002;132:1258-64. https://doi.org/10.1093/jn/132.6.1258
  14. Amusquivar E, Ruperez FJ, Barbas C, Herrera E. Low arachidonic acid rather than $\alpha$-tocopherol is responsible for the delayed postnatal development in offspring of rats fed fish oil instead of olive oil during pregnancy and lactation. J Nutr 2000;130:2855-65. https://doi.org/10.1093/jn/130.11.2855
  15. Ingold KU, Burton GW, Foster DO, Hughes L, Lindsay DA, Wbb A. Biokinetics of and discrimination between dietary RRR-and SRR-alpha-tocopherols in the male rat. Lipids 1987; 22:163-72. https://doi.org/10.1007/BF02537297

피인용 문헌

  1. Effects of Vitamin Forms and Levels on Vitamin Bioavailability and Growth Performance in Piglets vol.10, pp.14, 2020, https://doi.org/10.3390/app10144903
  2. Determination and Evaluation of Bioavailability of Vitamins from Different Multivitamin Supplements Using a Pig Model vol.11, pp.5, 2020, https://doi.org/10.3390/agriculture11050418