Asian-Australasian Journal of Animal Sciences

  • 제33권12호
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  • Pages.1930-1939
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  • 2020
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  • 1011-2367(pISSN)
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  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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Serum adipokines play different roles in type I and II ketosis

  • Shen, Liuhong (Department of Clinical Veterinary Medicine, Veterinary Medicine College, Sichuan Agricultural University) ;
  • Zhu, Yingkun (Department of Clinical Veterinary Medicine, Veterinary Medicine College, Sichuan Agricultural University) ;
  • Xiao, Jinbang (Department of Clinical Veterinary Medicine, Veterinary Medicine College, Sichuan Agricultural University) ;
  • Qian, Bolin (Department of Clinical Veterinary Medicine, Veterinary Medicine College, Sichuan Agricultural University) ;
  • You, Liuchao (Department of Clinical Veterinary Medicine, Veterinary Medicine College, Sichuan Agricultural University) ;
  • Zhang, Yue (Department of Clinical Veterinary Medicine, Veterinary Medicine College, Sichuan Agricultural University) ;
  • Yu, Shumin (Department of Clinical Veterinary Medicine, Veterinary Medicine College, Sichuan Agricultural University) ;
  • Zong, Xiaolan (Department of Clinical Veterinary Medicine, Veterinary Medicine College, Sichuan Agricultural University) ;
  • Cao, Suizhong (Department of Clinical Veterinary Medicine, Veterinary Medicine College, Sichuan Agricultural University)
  • 투고 : 2019.09.14
  • 심사 : 2019.11.25
  • 발행 : 2020.12.01
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초록

Objective: This study was conducted to investigate the differences in several serum adipokines in perinatal dairy cows with type I and II ketosis, and the correlations between these adipokines and the two types of ketosis. Methods: Serum adiponectin (ADP), leptin (LEP), resistin, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) levels, and energy balance indicators related to ketosis were measured. Type I and II ketosis were distinguished by serum glucose (Glu) and Y values and the correlations between adipokines in the two types of ketosis were analyzed. Results: β-Hydroxybutyric acid of type I ketosis cows was significantly negatively correlated with insulin (INS) and LEP and had a significant positive correlation with serum ADP. In type II ketosis cows, ADP and LEP were significantly negatively correlated, and INS and resistin were significantly positively correlated. Revised quantitative INS sensitivity check index (RQUICKI) values had a significantly positive correlation with ADP and had a very significant and significant negative correlation with resistin, TNF-α, and IL-6. ADP was significantly negatively correlated with resistin and TNF-α, LEP had a significantly positive correlation with TNF-α, and a significantly positive correlation was shown among resistin, IL-6, and TNF-α. There was also a significant positive correlation between IL-6 and TNF-α. Conclusion: INS, ADP, and LEP might exert biological influences to help the body recover from negative energy balance, whereas resistin, TNF-α, and IL-6 in type II ketosis cows exacerbated INS resistance and inhibited the production and secretion of ADP, weakened INS sensitivity, and liver protection function, and aggravated ketosis.

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참고문헌

  1. Ruprechter G, Adrien ML, Larriestra A, et al. Metabolic predictors of peri-partum diseases and their association with parity in dairy cows. Res Vet Sci 2018;118:191-8. https://doi.org/10.1016/j.rvsc.2018.02.005
  2. Sheldon IM, Cronin J, Goetze L, Donofrio G, Schuberth HJ. Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattle. Biol Reprod 2009;81:1025-32. https://doi.org/10.1095/biolreprod.109.077370
  3. Tatone EH, Duffield TF, LeBlanc SJ, DeVries TJ, Gordon JL. Investigating the within-herd prevalence and risk factors for ketosis in dairy cattle in Ontario as diagnosed by the test-day concentration of beta-hydroxybutyrate in milk. J Dairy Sci 2017;100:1308-18. https://doi.org/10.3168/jds.2016-11453
  4. Xu C, Li Y, Xia C, Zhang H, Sun L, Xu C. $^{1}H$ NMR-based plasma metabolic profiling of dairy cows with type I and type II ketosis. Pharm Anal Acta 2015;6:328. https://doi. org/10.4172/2153-2435.1000328
  5. Samad F, Badeanlou L, Shah C, Yang G. Adipose tissue and ceramide biosynthesis in the pathogenesis of obesity. In: Cowart LA, editor. Sphingolipids and metabolic disease. Advances in Experimental Medicine and Biology, vol 721. New York, NY, USA: Springer; 2011. pp. 67-86. https://doi.org/10.1007/978-1-4614-0650-1_5
  6. Luo M, Guo J, Huang G, Lu B, Yu W. Advances in research on the relationship between adipokines and metabolic syndrome. Progress in Modern Biomedicine 2014;11:2187-9.
  7. Wang Y, Xu A, Knight C, Xu LY, Cooper GJS. Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity. J Biol Chem 2002;277:19521-9. https://doi.org/10.1074/jbc.M200601200
  8. Ingvartsen KL, Boisclair YR. Leptin and the regulation of food intake, energy homeostasis and immunity with special focus on periparturient ruminants. Domest Anim Endocrin 2001;21:215-50. https://doi.org/10.1016/S0739-7240(02)00119-4
  9. Deng Y, Scherer PE. Adipokines as novel biomarkers and regulators of the metabolic syndrome. Ann NY Acad Sci 2010;1212:E1-19. https://doi.org/10.1111/j.1749-6632.2010.05875.x
  10. Kumari R, Kumar S, Kant R. An update on metabolic syndrome: Metabolic risk markers and adipokines in the development of metabolic syndrome. Diabetes Metab Syndr Clin Res Rev 2019;13:2409-17. https://doi.org/10.1016/j.dsx.2019.06.005
  11. Reid IM, Dew SM, Collins RA, Ducker MJ, Bloomfield GA, Morant SV. The relationship between fatty liver and fertility in dairy cows: a farm investigation. J Agric Sci 1983;101:499-502. https://doi.org/10.1017/S0021859600037874
  12. Wang J. Comparison and analysis of blood metabolic profiles between healthy cows with ketosis and subclinical hypocalcemia in perinatal period [dissertation]. Jilin, China: Jilin University; 2013.
  13. Li Y, Xu C, Xia C, Zhang H, Sun L, Gao Y. Plasma metabolic profiling of dairy cows affected with clinical ketosis using LC/MS technology. Vet Q 2014;34:152-8. https://doi.org/10.1080/01652176.2014.962116
  14. Zhang B, Guo H, Yang W, et al. Effects of ORAI calcium release-activated calcium modulator 1 (ORAI1) on neutrophil activity in dairy cows with subclinical hypocalcemia. J Anim Sci 2019;97:3326-36. https://doi.org/ https://doi.org/10.1093/jas/skz209
  15. Xu C, Shu S, Xia C, Wang B, Zhang HY, Jun B. Investigation on the relationship of insulin resistance and ketosis in dairy cows. J Vet Sci Technol 2014;5:162. https://doi.org/10.4172/2157-7579.1000162
  16. Cui Y, Wang Q, Chang R, Zhou X, Xu C. Intestinal barrier function-non-alcoholic fatty liver disease interactions and possible role of gut microbiota. J Agric Food Chem 2019;67: 2754-62. https://doi.org/10.1021/acs.jafc.9b00080
  17. Li X, Li Y, Ding H, et al. Insulin suppresses the AMPK signaling pathway to regulate lipid metabolism in primary cultured hepatocytes of dairy cows. J Dairy Res 2018;85:157-62. https://doi.org/10.1017/S002202991800016X
  18. Siddiqui K, George TP. Resistin role in development of gestational diabetes mellitus. Biomark Med 2017;11:579-86. https://doi.org/10.2217/bmm-2017-0013
  19. Sassek M, Pruszynska-Oszmalek E, Kolodziejski PA, et al. Resistin is produced by rat pancreatic islets and regulates insulin and glucagon in vitro secretion. Islets 2016;8:177-85. https://doi.org/10.1080/19382014.2016.1251538
  20. Cha S, Li Y, Zhang S, Feng P. Detection and analysis of plasma TNF-$\alpha$ and IL-6 in cows with endometritis. Chinese Cow 2016;4:42-4.
  21. KD Budras, RE Habel, KW Mulling, Greenough PR. Bovine anatomy. Hannover Germany: Schlutersche; 2011.
  22. Cao T. Investigation on the protective action of adiponectin against atrial fibrillation [dissertation]. Nanjing, China: Nanjing Tech University; 2014.
  23. Mao X, Kikani CK, Riojas RA, et al. APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol 2006;8:516-23. https://doi.org/10.1038/ncb1404
  24. Shen Z, Liang X, Rogers CQ, Rideout D, You M. Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol 2010;298:G364-74. https://doi.org/10.1152/ajpgi.00456.2009
  25. Yoon MJ, Lee GY, Chung JJ, Ahn YH, Hong SH, Kim JB. Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. Diabetes 2006;55:2562-70. https://doi.org/10.2337/db05-1322
  26. Heiker JT, Wottawah CM, Juhl C, Kosel D, Morl K, Beck-Sickinger AG. Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signaling. Cell Signal 2009;21:936-42. https://doi.org/10.1016/j.cellsig.2009.02.003
  27. Awazawa M, Ueki K, Inabe K, et al. Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway. Biochem Biophys Res Commun 2009; 382:51-6. https://doi.org/10.1016/j.bbrc.2009.02.131
  28. Yu G. Effect of bovine recombinant adiponectin on key enzymes of fat metabolism in dairy cows [dissertation]. Jilin, China: Jilin University; 2011.
  29. Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7:941-6. https://doi.org/10.1038/90984
  30. Yu-Duan T, Chao-Ping W, Chih-Yu C, et al. Elevated plasma level of visfatin/pre-b cell colony-enhancing factor in male oral squamous cell carcinoma patients. Med Oral Patol Oral Cir Bucal 2013;18:e180-6. https://doi.org/10.4317/medoral.18574
  31. Huang S, Xu Y, Peng WF, et al. Asymmetric dimethylarginine targets MAPK pathway to regulate insulin resistance in liver by activating inflammation factors. J Cell Biochem 2018;120: 7474-81. https://doi.org/10.1002/jcb.28021
  32. Wang Y, He B, Li X. Changes and significance of TNF-$\alpha$, IL-6 and NO in plasma of patients with hypertensive insulin resistance. J China Med Univ 2006;5:525-6. https://doi.org/10. 3969/j.issn.0258-4646.2006.05.032
  33. Dali-Youcef N, Mecili M, Ricci R, Andres E. Metabolic inflammation: connecting obesity and insulin resistance. Ann Med 2013;45:242-53. https://doi.org/10.3109/07853890.2012.705015
  34. Holtenius P, Holtenius K. A model to estimate insulin sensitivity in dairy cows. Acta Vet Scand 2007;49:29. https://doi.org/10.1186/1751-0147-49-29
  35. Wei D, Zhao H, Ceng R, Zhang B. Effect of phlegm and blood stasis therapy on inflammatory factors IL-6, IL-18 and TNF-$\alpha$ in nonalcoholic fatty liver disease. Chinese J Tradit Chinese Med 2018;33:1631-3.
  36. Wu Q, Jin Y, Ni H. Effect of kaempferol on correlation factors of chronic complications of type 2 diabetic rats. Chinese Herbal and Herbal Drugs 2015;12:1806-9. https://doi.org/10.7501/j.issn.0253-2670.2015.12.018

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